Core E: Laboratory and biobehavioral marker core

核心E：摘要/总结 与中心的主题一致，核心E的使命是促进广泛的生物和 行为干预研究，旨在优化精神病学，行为和医疗结果 艾滋病毒感染者中。核心将为所有试点项目进行分析，以及设计和 实施新的分析。该核心将进行实验室和影像学评估，以确定精神 与艾滋病毒/艾滋病有关的疾病和并发症以及与各种 行为和药物干预。核心将受益于佩雷尔曼的主要优势 医学院（PSOM），CHOP，中心，部门和学校在宾夕法尼亚大学。我们将确定具体 以及与精神疾病和HIV/AIDS合并症相关的潜在独特生物标志物。这些 将收集在试点和其他核心中研究的所有受试者的数据。核心将进行以下分析： 体液和细胞，包括免疫、炎症、压力和健康的标志物。核心还将携带 神经成像和神经认知测量。该核心将评估与艾滋病毒治疗有关的问题， 心理健康和合并症核心由两名高级调查员道格拉斯博士和古尔博士领导。的 核心将支持中心的科学议程和发展计划。核心资源将紧密 与宾夕法尼亚大学的现有资源互动，这是PMHARC的使命的核心。核心主任， 道格拉斯和联合主任古尔在宾夕法尼亚大学担任领导职务。核心将被独特地定位， 制定并监督质量控制和质量保证标准化选择影像学、生化 标记物、神经心理行为测试和实验室测试。核心将与所有 其他PMHARC核心，最密切的是与临床评估核心，以努力收集综合 一组患有各种精神疾病的艾滋病毒阳性者的“最先进”生物医学和行为数据 以更好地了解疾病轨迹、发病率和临床结果。

CORE E: ABSTRACT/SUMMARY Consistent with the Center's theme, the mission of Core E is to facilitate a broad range of biological and behavioral intervention studies that are designed to optimize psychiatric, behavioral, and medical outcomes among HIV infected individuals. The Core will perform assays for all Pilot Projects, as well as design and implement novel assays. This Core will perform laboratory and imaging assessments that define the mental illnesses and co-morbidities related to HIV/AIDS and unique modeling and measurements related to various behavioral and pharmacologic interventions. The Core will benefit from the major strengths of the Perelman School of Medicine (PSOM), CHOP, Centers, Departments, and Schools at UPenn. We will identify specific and potentially unique biomarkers which are related to mental illness and to comorbidities of HIV/AIDS. These data will be collected for all subjects to be studied in pilots and other Cores. The Core will perform assays of body fluids and cells including markers of immunity, inflammation, stress, and health. The Core will also carry out neuroimaging and neurocognitive measures. The Core will assessments related to therapeutics for HIV, mental health, and co-morbidities. The Core is directed by two senior investigators, Drs. Douglas and Gur. The Core will support the Center's scientific agenda and developmental program. This Core resource will closely interact with existing resources at UPenn, which are central to the mission of the PMHARC. The Core Director, Douglas, and Co-Director, Gur, are in leadership roles at UPenn. The Core will be uniquely positioned to carry out and monitor the quality control and quality assurance of standardized selected imaging, biochemical markers, neuropsychological behavioral testing, and laboratory testing. The Core will work closely with all the other PMHARC Cores, and most closely with the Clinical Assessment Core, in an effort to gather integrated 'state-of-the-art' biomedical and behavioral data on a cohort of HIV+ persons with a variety of mental illnesses in an effort to better understand disease trajectories, morbidities and clinical outcomes.