One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food

项目摘要 在美国，用于宠物消费的食物通常对宠物和食用宠物的人都是安全的。 处理食物。抗生素耐药性（AMR）及其传播是关键问题。理解提高 AMR检测及其传播是一个重要问题。准备好应对旧的新病原体的能力 至高无上。从目前的大流行中可以清楚地看到，SARS-CoV-2已经导致数百万人患病和死亡 国际吧它也有生病的宠物，许多物种在动物园收藏，似乎已经找到了一个 水库在鹿。问题的严重程度仍未得到充分认识。 格鲁吉亚（UGA）的大学致力于促进，培训，并在所有领域进行研究 动物、人类和环境健康。兽医学院和国家兽医学院 诊断实验室（AVDL）有责任对国家及其组成部分进行诊断，监测趋势， 报告不寻常的疾病表现或模式。AVDL实验室得到了我们机构的支持， CLIA于2020年获得认证，并于当年8月开始进行人类COVID 19 PCR检测， UGA社区继续其教学，研究和服务任务。此外，PI执行 2021年1月进行唾液测试，以改善样本收集和监测参与。我们处理 超过8万个人体样本，测试至今仍在继续。我们对兽医界的服务并没有 在这段时间里动摇。除了常规的兽医诊断服务外， 发现宠物和动物园物种感染了SARS-CoV-2。 我们的实验室拥有病理学、细菌学、寄生虫学、病毒学、血清学和分子生物学方面的专业知识， 包括高通量平台测试，如COVID 19测试所示。我们的教职员工是 我们是一家高素质的公司，致力于动物和公共卫生。我们的承诺体现在我们参与 在州和国家一级的许多方案。我们是国家动物卫生实验室网络之一 （NAHLN），并参与所有NAHLN监测和抗生素耐药性测试和测序。在 此外，我们还参与了与FDA的其他合作协议， 沙门氏菌在火鸡为基础的宠物治疗和从事流行病学研究， 猫狗粪便中的沙门氏菌及其携带的潜在危险因素。我们也是FDA 细菌分离源实验室的抗菌持续耐药性测试项目。 此外，我们目前正处于第二次竞争性延长基础设施赠款的最后一年， 我们在此寻求更新我们一直非常积极地响应这项赠款的所有要求， 约会因此，雅典兽医诊断实验室和本申请中的PI是唯一 帮助FDA实现本竞争性文件中所述项目的关键目标。 退款

Project Summary In the United States, food destined for pet consumption usually is safe for both the pets and the people who handle the food. Antimicrobial resistance (AMR) and its spread are crucial issues. Understanding improving AMR detection and its spread is an essential issue. The ability to be ready to respond to old new pathogens is paramount. It is clear from the current pandemic, where SARS-CoV-2 has sicked and killed millions of people worldwide. It also has sickened pets, many species held in zoo collections, and seems to have found a reservoir in deer. The extent of the problem is still not fully recognized. The University of Georgia (UGA) is committed to promoting, training, and conducting research in all areas of animal, human and environmental health. The College of Veterinary Medicine and the State Veterinary Diagnostic Laboratory (AVDL) have a duty to the state and its constituents to diagnose, monitor trends, and report unusual disease presentations or patterns. The AVDL laboratory is supported by our institution obtained CLIA accreditation in 2020 and started performing human COVID19 PCR testing in August of that year to help the UGA community continue its teaching, research, and service missions. Moreover, the PI implemented saliva testing in January 2021 to improve sample collection and surveillance participation. We have processed over 80,000 human samples, and testing continues today. Our service to the veterinary community did not waver during this time. In addition to the regular veterinary diagnostic service, the molecular section also tested and found pets and zoo species sickened by SARS-CoV-2. Our laboratory has expertise in pathology, bacteriology, parasitology, virology, serology, and molecular biology, including high throughput platform testing as demonstrated with COVID19 testing. Our faculty and staff are highly qualified and are devoted to animal and public health. Our commitment is evident in our participation in many programs at the state and national levels. We are one of the National Animal Health Laboratory Network (NAHLN) and participate in all NAHLN surveillance and antimicrobial resistance testing and sequencing. In addition, we have participated in other cooperative agreements with the FDA assessing the presence of Salmonella in turkey-based pet treats and engaging in an epidemiological study looking at the prevalence of Salmonella in dog and cat feces and the potential risk factors for Salmonella carriage. We are also an FDA bacterial isolate source laboratory for their antimicrobial continued resistance testing project. Furthermore, we are currently in the last year of our second competitive renewal of this infrastructure grant, for which hereby we are seeking renewal. We have been very responsive to all the requirements of this grant to date. Therefore, Athens Veterinary Diagnostic Laboratory and the PI in this application are uniquely positioned to assist the FDA in meeting the critical goals of the project described in this competitive renewal.