LEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders Study
传说:将神经发育和神经退行性疾病研究的流行病学和遗传学联系起来
基本信息
- 批准号:10635458
- 负责人:
- 金额:$ 80.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAffectAge of OnsetAgingAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmyotrophic Lateral SclerosisAttention deficit hyperactivity disorderBiological AgingBiological ClocksBrain regionCardiometabolic DiseaseCessation of lifeChildCountryDataDementiaDenmarkDevelopmentDiseaseElderlyEpidemiologyEpigenetic ProcessFamilyFamily history ofGeneral PopulationGenesGeneticGenotypeIntellectual functioning disabilityInterventionKnowledgeLinkMediatorMendelian randomizationMolecularNatural HistoryNatureNerve DegenerationNeurodegenerative DisordersNeurodevelopmental DisorderOnset of illnessParkinson DiseasePersonsPhenotypePhysical FunctionPhysical activityPopulationPrevalenceProcessProspective cohortRecording of previous eventsRiskRisk FactorsSwedenTissuesadult with autism spectrum disorderautism spectrum disorderbiobankburden of illnesscognitive functioncognitive reservecohortdementia riskepidemiology studyfollow-upgenome wide association studyhazardhigh riskhuman old age (65+)individuals with autism spectrum disordermortalityneurodevelopmental effectpolygenic risk scorerisk mitigation
项目摘要
Project Abstract
Emerging evidence suggests that certain neurodevelopmental disorders – autism (ASD), attention-deficit
hyperactive disorder (ADHD), and intellectual disability (ID) – may increase risk of later life neurodegenerative
disorders such as Alzheimer’s disease or related dementia (ADRD), Parkinson’s disease (PD), and
amyotrophic lateral sclerosis (ALS). We propose a multinational study of epidemiological and genetic data
across the countries of Sweden, Denmark, and the UK to characterize the natural history (Aim 1) and familial
aggregation (Aim 2) of these disorders. We also explore genetic links (Aim 3) between neurodevelopmental
and later life neurodegenerative disorders, and identify potential targets for intervention that may mitigate risk
(Aim 4).
Our study will use data from 10+ million persons from Sweden and Denmark with decades of follow-up; iPSYCH,
an extensively genotyped case-cohort with ~25,000 ASD, ~30,000 ADHD cases, and 50,000 controls; and a
prospective cohort of older adults from the UK (UK Biobank) totaling over half a million persons. Our analytic
approach links epidemiological and genetic data, that together, triangulate to answer the question of whether
ASD, ADHD, and ID increase risk of ADRD, PD, and ALS.
项目摘要
新出现的证据表明,某些神经发育障碍-自闭症(ASD),注意力缺陷,
多动症(ADHD)和智力残疾(ID)-可能会增加晚年神经退行性疾病的风险
病症,如阿尔茨海默病或相关痴呆(ADRD)、帕金森病(PD),和
肌萎缩侧索硬化症(ALS)。我们建议对流行病学和遗传学数据进行多国研究
在瑞典、丹麦和英国的国家,以表征自然史(目标1)和家族史(目标2)。
这些疾病的聚集(目的2)。我们还探讨了神经发育与神经发育之间的遗传联系(目的3)。
和晚年神经退行性疾病,并确定可能减轻风险的干预的潜在目标
(Aim 4).
我们的研究将使用来自瑞典和丹麦的1000多万人的数据,并进行数十年的随访; iPSYCH,
一个广泛基因分型的病例队列,约25,000例ASD,约30,000例ADHD病例和50,000例对照;
来自英国的老年人前瞻性队列(英国生物银行),总计超过50万人。我们的分析
这种方法将流行病学和遗传学数据联系起来,一起进行三角测量,以回答以下问题:
ASD、ADHD和ID会增加ADRD、PD和ALS的风险。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brian Kane Lee其他文献
Brian Kane Lee的其他文献
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{{ truncateString('Brian Kane Lee', 18)}}的其他基金
Maternal epilepsy, antiepileptic drug use during pregnancy, and risk of autism
孕产妇癫痫、怀孕期间抗癫痫药物的使用以及自闭症的风险
- 批准号:
9816282 - 财政年份:2019
- 资助金额:
$ 80.67万 - 项目类别:
Maternal epilepsy, antiepileptic drug use during pregnancy, and risk of autism
孕产妇癫痫、怀孕期间抗癫痫药物的使用以及自闭症的风险
- 批准号:
10444997 - 财政年份:2019
- 资助金额:
$ 80.67万 - 项目类别:
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