Statistical methods to understand changes in dietary patterns over time and cardiovascular disease risk among understudied populations

项目摘要 我的目标是建立自己作为一个独立的研究心血管疾病（CVD）的差异， 在贝叶斯非参数聚类技术和营养流行病学的专业知识。实现这些 目标将需要有重点的教学培训和研究指导。我的研究目标是开发新的 确定与研究不足和边缘化人群CVD风险相关的时间饮食模式的方法 分组。这些新方法将确定饮食暴露的差异，发生在人口之间的差异， 美国在过去的时间，否则可能会被忽视。我还将开发方法来评估这些 短期饮食暴露模式影响成年女性心血管疾病风险结果。有两个国家卫生研究院- 受资助的女性队列研究-黑人妇女健康研究和护士健康研究II -我将申请 研究美国妇女随时间变化的多变量饮食暴露变化的拟议方法及其 与CVD健康差异的相关性，突出了种族/民族亚群定义的差异。 通过实施所提出的方法和应用到两个大的基于人口的队列，这 研究将描述心血管疾病差异风险最大的亚组的饮食行为， 未来的政策，以改善饮食建议和促进人口健康公平。实现我 培训目标，拟议的培训计划包括四个要素：（1）教学部分，以扩大我的 在营养和心血管疾病流行病学和差距的专业知识;（2）在方法学的职业指导 发展对大量不同人口的营养数据的重复测量分析;（3）创新 利用在营养和心血管疾病流行病学方面获得的内容专业知识和以前的统计培训进行研究; 以及（4）通过参加以下会议，在生物统计学、营养流行病学和心血管疾病差异方面交流意见： 会议、研讨会和讲习班。计划的培训活动将提高我对饮食的理解 消费行为，心血管疾病流行病学和差异，使我能够开发有用的模型来衡量 随着时间的推移，多元饮食暴露模式和脆弱人群的心血管疾病风险估计。的技能 在这个奖项期间发展的经验将使我准备领导一个跨学科的研究 计划解决与心脏代谢健康差异相关的因素。

PROJECT SUMMARY My goal is to establish myself as an independent researcher on cardiovascular disease (CVD) disparities with expertise in Bayesian nonparametric clustering techniques and nutrition epidemiology. Attaining these objectives will require focused didactic training and research guidance. My research goals are to develop new methodology to identify temporal dietary patterns that are related to CVD risk of understudied and marginalized subgroups. These new methods will identify dietary exposure differences that occur across populations in the United States over time that otherwise may be overlooked. I will also develop methods to assess how these temporal dietary exposure patterns impact CVD risk outcomes for adult women. With access to two NIH- funded female cohort studies—the Black Women’s Health Study and the Nurses’ Health Study II —I will apply the proposed methods to examine multivariate dietary exposure changes of US women over time and their association with CVD health disparities, highlighting differences defined by racial/ethnic subpopulations. Through implementation of the proposed methods and application to two large population-based cohorts, this research will characterize the dietary behaviors of subgroups at greatest risk of CVD disparities and inform future policies to improve dietary recommendations and promote population health equity. To achieve my training goals, the proposed training plan consists of four elements: (1) a didactic component to expand my expertise in nutrition and CVD epidemiology and disparities; (2) career guidance in methodological development in repeated measures analysis of nutritional data of large, diverse populations; (3) innovative research using gained content expertise in nutrition and CVD epidemiology and previous statistical training; and (4) exchange of ideas in biostatistics, nutrition epidemiology, and CVD disparities through attendance at conferences, seminars, and workshops. Planned training activities will enhance my understanding of dietary consumption behaviors, CVD epidemiology, and disparities enabling me to develop useful models to measure multivariate dietary exposure patterns over time and CVD risk estimation for vulnerable populations. The skills and experience developed during this award period will prepare me to lead an interdisciplinary research program addressing factors associated with cardiometabolic health disparities.