Bioenergetics Core

项目摘要-生物能量学核心 使用当代活细胞代谢分析平台的生物能量测量提供了对 能量代谢的各种参数。与现有的流式细胞仪分析平台相辅相成 测量不同的线粒体和细胞功能参数，生物能量学(Bio-E)核心将形成一个 阿肯色州综合代谢研究中心(AIMRC)的关键组成部分。Bio-E核心将是一个新的核心 为满足拟建的科布雷中心的新陈代谢研究需求而创建。Bio-E核心将协调 与AIMRC成像与光谱和数据科学核心密切合作，生成跨学科 框架，并允许项目负责人对细胞和组织新陈代谢进行新的了解，从而使新的 这些发现以及这些发现的临床翻译。生物与生物之间密切的协作互动 E核心和Cobre项目负责人以及成像和光谱和数据科学核心将领导 致力于研究方法的新创新，这将使未来的Cobre研究人员以及更广泛的人受益 校园研究社区。活体细胞代谢分析和流式细胞仪技术的实践培训 将提供给中心成员、校园和阿肯色州的生物医学研究人员。

Project Summary – Bioenergetics Core Bioenergetic measurements using contemporary live-cell metabolic assay platforms provides insights into various parameters of energy metabolism. Complemented by established flow cytometry assay platforms to measure different mitochondrial and cellular functional parameters, the Bioenergetics (Bio-E) core will form a key component of Arkansas Integrative Metabolic Research Center (AIMRC). The Bio-E core will be a new core created to meet the metabolic research needs of the proposed COBRE center. The Bio-E core will coordinate closely with the AIMRC Imaging and Spectroscopy and Data Science Cores to generate a cross-disciplinary framework and allow project leaders to shed new light on cell and tissue metabolism, thus enabling novel discoveries, as well as clinical translation of such discoveries. Close collaborative interactions between the Bio- E Core and COBRE project leaders as well as the Imaging and Spectroscopy and Data Science Cores will lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Hands-on training in live-cell metabolic assays and flow cytometry technologies will be provided to Center members, the campus and biomedical researchers in Arkansas.