Methods Core

抽象方法核心 方法核心通过指导测量、统计方法和 实施科学贯穿中心的目标和计划，最大限度地发挥创新和影响。它适用于 方法专门评估精神健康、物质使用和社会影响的专业知识 健康对艾滋病毒相关治疗和预防结果的结构性决定因素。我们对一个 艾滋病毒研究环境，生物医学战略组合不断扩大，包括艾滋病毒长效剂 预防和治疗，以及整合来自多个数据来源的信息的需求日益增长(例如， 基于移动电话的评估、电子健康记录、实验室数据、行政和公共使用 数据库)。推动实施科学、社区合作研究和团队科学 要求开发新的方法。方法核心也针对测量和评估 在发展艾滋病毒方面，不同种族/民族和性别/性别的少数群体之间持续存在差异 开展研究者发起的研究和以服务为导向的活动时的研究方法。这个 具体目标是：(1)科学：通过发展和促进尖端艾滋病毒研究 传播艾滋病毒防治相结合的创新技术和分析战略 超越个别模式的研究，包括但不限于实施科学；(2) 网络：将跨学科和跨网络的科学家联系起来，具有互补的专业知识和 社区合作伙伴双向告知可用的研究工具，并确定分析领域取得进展的需求 方法；以及(3)能力建设：招募、指导和支持高素质的调查人员 方法专业知识，并通过面对面传播创新方法、评估工具和平台 以及虚拟培训活动，重点是来自科学界代表性不足的少数群体的新兴科学家。 方法核心以广泛的因果推理范式为指导，以保持所有方法的科学基础 在研究活动和评估潜在影响方面。方法核心将确定三个领域的优先次序：(A) 统一多个数据来源的证据；(B)针对复杂应用背景的统计方法 包括管理高维测量、各种数据类型、丢失数据和其他 艾滋病毒预防研究的复杂性；(C)传播和实施科学协商，利用 参与式方法，平衡保真度和适应性，确定核心要素，建立决策模型- 采取干预措施，应用系统分析工具。在住房“加州大学洛杉矶分校快速，严谨， 相关实施科学中心“，核心进一步扩大能力，支持和指导 艾滋病毒预防方面的实施科学原则和最佳做法。

ABSTRACT – METHODS CORE The Methods Core supports the CHIPTS mission by guiding measurement, statistical methods, and implementation science across the center's aims and initiatives, maximizing innovation and impact. It applies methods expertise specifically toward assessing influences of mental health, substance use, and social and structural determinants of health on HIV-associated treatment and prevention outcomes. We respond to an HIV research environment with an expanding mix of biomedical strategies, including long-acting agents for HIV prevention and treatment, as well as a growing need to integrate information from multiple data sources (e.g. mobile-phone-based assessments, electronic health records, laboratory data, administrative and public-use databases). The push toward implementation science, community-partnered research, and team science demands development of new methods. The Methods Core also targets measurement and evaluation of persistent disparities across diverse racial/ethnic and sexual/gender minority populations in advancing HIV research methodology when conducting investigator-initiated research and service-oriented activities. The specific aims are (1) Science: To foster and facilitate cutting-edge HIV research by developing and disseminating innovative technologies and analytic strategies for combination HIV prevention and treatment research that transcends individual models, including but not limited to implementation science; (2) Networking: To connect scientists across disciplines and across networks with complementary expertise and community partners to bi-directionally inform available research tools and identify need for advances in analytic methodologies; and (3) Capacity building: To recruit, mentor, and support high-caliber investigators with methods expertise and disseminate innovative methods, assessment tools, and platforms through in-person and virtual training activities with emphasis to emerging scientists from underrepresented minorities in science. The Methods Core is guided by a broad causal-inference paradigm to maintain a scientific foundation in all research activities and in evaluating potential impacts. The Methods Core will prioritize three areas: (a) Harmonizing evidence across multiple data sources; (b) Statistical methods for complex applied contexts including management of high-dimensional measurements, of varying data types, of missing data, and of other complexities in HIV prevention research; (c) Dissemination and implementation science consultations utilizing participatory approaches, balancing fidelity and adaptation, identifying core elements, modeling decision- making in intervention adoption, and applying system-analytical tools. In housing the “UCLA Rapid, Rigorous, Relevant Implementation Science Hub”, the core further expands its capacity to support and guide implementation science principles and best practices in HIV prevention.