RFA-CK-22-002, Adaptation and assessment of smartphone technology to improve the implementation and evaluation of One Health systems for rabies control and surveillance globally

1个项目摘要 狂犬病是最具破坏性的疾病之一，一旦出现临床症状，几乎100%的病例死亡。 每年数以万计的人死于狂犬病，其中绝大多数发生在低至 非洲和亚洲的4个中等收入国家(LMIC)，通过狂犬病狗的叮咬传播。 5与许多被忽视的热带疾病不同，狂犬病是完全可以预防的，只要及时提供 6暴露后预防(PEP)和通过大规模接种犬类疫苗消除 7已经证明是既可实现又具有成本效益的。然而，儿童和那些在 8社会的社会经济和地理边缘更有可能死于狂犬病，因为 9在获得公共卫生服务和教育方面的不平等，往往死于可怕的环境中 10没有任何姑息治疗。由于外业收集有限，数据质量一直很差 11被认为是狂犬病控制的最重要障碍，这给基于证据的研究蒙上了阴影 12项政策和阻碍成功的控制措施。智能手机和在线技术已经 13彻底改变了项目经理与其远程员工之间的连接，实现了现场- 14、方案数据和空间通信的数字捕获和传输 15幅交互式地图。由此产生的关于寄主种群分布和空间分布的高分辨率数据 16例暂时性狂犬病病例发病率为优化控制策略提供了新的机会 17和成本效益。该项目建立在长期建立的狂犬病控制干预方案的基础上。 18跨拉丁美洲、亚洲和非洲，并开发了一个多功能技术平台来支持 19次群众性犬只接种和监测活动。进一步的技术开发将集中在 20促进系统的广泛民主化、与国家和国际的一体化 支持数据驱动的狂犬病控制规划和改进的21个平台和方法 22场竞选活动。地图绘制、疫苗接种后评估和报告流程的自动化将 23使战略和协议与循证的国际最佳做法保持一致 24.宣传活动的实施，并鼓励与各级利益攸关方接触。网络的影响 关于疫苗接种资源地理优先次序的25种新方法 26和狂犬病传播将进行评估。为疫苗接种团队提供自动化的应用内指导 27指导、PEP方案安排和对疑似狂犬病犬的调查将被评估为 28与非技术援助的方法相比。该项目的成果将开启国内的大门 29实施有效的“一项健康”狂犬病控制干预措施的能力并加快 30在实现2030年消除由狗传播的人类狂犬病的全球目标方面取得进展。

1 Project summary 2 Rabies is one of the most devastating diseases, with near 100% case fatality once clinical signs occur. 3 The vast majority of the tens of thousands of human deaths from rabies every year occur in low- to 4 middle-income countries (LMICs) of Africa and Asia, transmitted through a bite from a rabid dog. 5 Unlike many neglected tropical diseases, rabies is entirely preventable through timely provision of 6 post-exposure prophylaxis (PEP) and elimination through mass vaccination of the dog population has 7 been demonstrated to be both achievable and cost-effective. Nevertheless, children and those at 8 the socioeconomic and geographic margins of society are more likely to die of rabies due to 9 inequities in access to public health services and education, often dying in horrific circumstances 10 without any palliative care. Poor data quality, stemming from limited field-level collection, has been 11 implicated as the singularly most important barrier to rabies control, clouding evidence-based 12 policies and hampering successful control measures. Smartphone and online technologies have 13 revolutionized connectivity between program managers and their remote workforce, enabling field- 14 side digital capture and transmission of programmatic data and spatial communication through 15 interactive maps. The resulting high-resolution data on host population distribution and spatio- 16 temporal rabies case incidence provides new opportunities to optimize control strategies for efficacy 17 and cost-efficiency. This project builds on a long-established program of rabies control interventions 18 across Latin America, Asia and Africa and a versatile platform of technologies developed to support 19 mass dog vaccination and surveillance activities. Further technology development will focus on 20 facilitating widespread democratization of systems, integration with national and international 21 platforms and approaches to support data-driven planning and refinement of rabies control 22 campaigns. Automation of processes for mapping, post-vaccination evaluation and reporting will 23 serve to align strategies and protocols with evidence-based international best-practices for 24 campaign implementation and stimulate engagement with stakeholders at all levels. The impact of 25 novel approaches to the geographic prioritization of vaccination resource on campaign efficiency 26 and rabies transmission will be evaluated. Automated in-app guidance for vaccination team 27 direction, PEP regimen scheduling and the investigation of suspect rabid dogs will be evaluated as 28 compared to non-technology aided approaches. Outcomes of the project will unlock in-country 29 capacity for the implementation of effective One Health rabies control interventions and accelerate 30 progress towards the 2030 global goal for dog-transmitted human rabies elimination.