Novel aspects of the renin angiotensin system in cardio-renal disease

心血管疾病和慢性肾脏疾病是澳大利亚发病率和流行率不断上升的主要公共卫生问题。这些疾病之间存在复杂的因果关系，每一种疾病都可能由另一种疾病引起或成为另一种疾病的并发症。本提案将研究一个重要的激素系统，肾素血管紧张素系统，在实验模型和心脏和肾脏疾病患者中的作用。结果可能会在血液中发现新的标记物，可以预测某人是否会患上肾脏疾病。

Cardiovascular disease and chronic kidney disease are major public health problems with increasing incidence and prevalence in Australia. There are complex causal relationships between these diseases, and each of them may be caused by or be a complication of the other. This proposal will investigate the role of an important hormone system, the renin angiotensin system, in experimental models and in patients with heart and kidney disease. The results may identify novel markers in the blood that can predict if someone will develop kidney disease.