华盛顿产胎儿药理学研究单位-猫眼课题宝

华盛顿产胎儿药理学研究单位

批准号：

7695403

负责人：

MENACHEM MIODOVNIK

金额：

$13.5万

依托单位：

GEORGETOWN UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-07-01 至 2010-04-30

来源：

https://reporter.nih.gov/project-details/7695403

关键词：

17 year old 6 year old AIDS Treatment Research AIDS Vaccines AIDS clinical trial group AIDS/HIV problem Abruptio Placentae Absence Epilepsy Academic Medical Centers Academy Accountability Accounting Accreditation Acetamides Achievement Acoustics Acquired Immunodeficiency Syndrome Acute Adaptive Behaviors Address Admission activity Adolescence Adolescent Adopted Adrenal Cortex Hormones Adrenal Glands Adult Advanced Development Adverse effects Adverse event Advertisements Advisory Committees Affect African American Aftercare Age Age-Months Age-Years Aging Agreement Alaska Native Alcohol abuse Aldosterone Algorithms All Sites Alzheimer&apos s Disease American American Indians Amino Acid Sequence Amino Acids Amniocentesis Analysis of Variance Anatomy Ancillary Study Androstenedione Anemia Anesthesia procedures Anesthesiology Angina Pectoris Angiography Angiotensin II Angiotensins Animal Experimentation Animal Feed Animal Housing Animal Model Animal Technicians Animals Anisotropy Anti-Inflammatory Agents Anti-Retroviral Agents Antibiotic Resistance Antibiotic Therapy Antibodies Anticonvulsants Antiepileptic Agents Antineoplastic Agents Antioxidants Anxiety Apnea Apoptosis Apoptotic Appearance Appendix Applications Grants Appointment Archives Area Arrhythmia Arteries Arts Asians Aspirin Asthma Atrial Natriuretic Factor Attention Attenuated Auditory Autistic Disorder Autopsy Aversive Stimulus Award Awareness BIA 2-024 BIA 2-093 Bacteria Bacterial Vaginosis Barbiturates Basal Ganglia Basic Science Bass Beck depression inventory Beclomethasone Bed rest Beds Behavior Behavior assessment Behavioral Benefits and Risks Benign Benzodiazepines Berlin Binding Binding Sites Biochemical Biochemistry Biochemistry and Pharmacology Cancer Activity Bioethics Bioinformatics Biological Assay Biological Availability Biological Markers Biological Warfare Biology Biomedical Research Biometry Biophysics Birth Birth Weight Birth trauma Blinded Blood Blood Circulation Blood Pressure Blood Vessels Blood specimen Body Temperature Body Weight Boxing Brain Brain Chemistry Brain Injuries Brain Mass Brain imaging Brain natriuretic peptide Brain region Brain-Derived Neurotrophic Factor Breast Breathing Budgets Burn Centers Butyric Acid Butyric Acids CYP3A4 gene Calcineurin inhibitor Calcium Caliber California Cancer Biology Cancer Center Cancer and Leukemia Group B Candida Capital Carbamazepine Carbon Dioxide Cardiac Cardiac Output Cardiovascular Agents Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Caring Carrier Proteins Case Study Case-Control Studies Castration Caucasians Caucasoid Race Cavia Cell Death Cell Line Cell Nucleus Cell Separation Cells Cellular biology Centers for Disease Control and Prevention (U.S.)Central Nervous System Depressants Cerebellum Cerebral Dominance Cerebrum Certification Cervical Cesarean section Cessation of life Chairperson Characteristics Chemicals Child Child Care Child Development Child Psychology Childhood Chiroptera Chloral Hydrate Chorionic Villi Sampling Chromatography Chromosome abnormality Chromosomes Chronic Circadian Rhythms Civil Rights Classification Cleaved cell Cleft Lip Clinic Clinical Clinical Chemistry Clinical Data Clinical Drug Development Clinical Investigator Clinical Management Clinical Nurse Specialists Clinical Nursing Clinical Nursing Research Clinical Pharmacology Clinical Pharmacy Service Clinical Practice Guideline Clinical Research Clinical Treatment Clinical Trials Clinical Trials Cooperative Group Clinical Trials Design Clinical Trials Network Clinical Trials-Pediatric AIDS Clonazepam Cocaine Code Cognition Cognition Disorders Cognitive Cognitive deficits Cohort Studies Collaborations Collagen Color Colposcopy Communicable Diseases Communities Community Hospitals Community Physician Community Services Compatible Complement Complex Comprehensive Health Care Computer Simulation Computer information processing Computer software Computerized Medical Record Condition Conduct Clinical Trials Confidence Intervals Confidential Information Confidentiality Conflict (Psychology)Conflict of Interest Confounding Factors (Epidemiology)Congenital Abnormality Consensus Consent Consent Forms Consult Consultations Contracts Contrast Media Control Groups Controlled Clinical Trials Convulsions Coordination and Collaboration Cordocentesis Core Facility Corpus striatum structure Cotyledon plant Counseling Count Coupled Couples Cream Creatine Creatinine Critical Illness Cryopreservation Cues Cultural Backgrounds Custom Cyclosporine Cyclosporins Cystic Fibrosis Cytogenetics Cytogenetics Shared Resource DAPI DNA DNA Fragmentation DNA Nucleotidylexotransferase DNA Sequence DNA Sequence Rearrangement DNA analysis DNTT gene Daily Data Data Analyses Data Collection Data Reporting Data Security Data Set Data Sources Data Storage and Retrieval Databases Date/Time Decision Making Defect Delivery Rooms Densitometry Depressed mood Derivation procedure Dermal Detection Developed Countries Developing Countries Development Developmental Delay Disorders Developmental Therapeutics Program Devices Diabetes Mellitus Diabetic Angiopathies Diabetic Nephropathy Diagnosis Diagnostic Diagnostics Research Diazepam Dietary Calcium Diffusion Diffusion Magnetic Resonance Imaging Digoxigenin Digoxin Direct Costs Disabled Children Disabled Persons Discipline Discipline of Nursing Discipline of obstetrics Discrimination Disease Disease Progression Disease regression Dissociation District of Columbia Doctor of Medicine Doctor of Philosophy Documentation Dorsal Dosage Forms Dose Double-Blind Method Down Syndrome Drainage procedure Dropout Drug Addiction Drug Approval Drug Delivery Systems Drug Evaluation Drug Exposure Drug Formulations Drug Industry Drug Interactions Drug Kinetics Drug Labeling Drug Monitoring Drug Transport Drug effect disorder Drug usage Drug vehicle Dyslexia Dystocia Early Intervention Early treatment Eating Behavior Echo-Planar Imaging Echocardiography Economics Education Educational Curriculum Educational Status Educational process of instructing Educational workshop Effectiveness Effectiveness of Interventions Electroencephalography Electron Microscopy Elements Embryo Transfer Emotional Endocrinology Endoribonucleases Endothelium Enrollment Ensure Environment Enzymes Epidemiology Epilepsy Epithelial Epoxide hydrolase Epoxy Compounds Equilibrium Equipment Equipment and supply inventories Equus caballus Error Sources Erythromycin Estradiol Estriol Estrogens Etanercept Ethanol Ethosuximide Etiology European Euthanasia Evaluation Evaluation Research Event Evoked Potentials, Auditory, Brain Stem Exanthema Excision Excretory function Exhibits Experimental Designs Experimental Models Exposure to Extracorporeal Membrane Oxygenation Extramural Activities Eye Face Facilities and Administrative Costs Facility Construction Funding Category Faculty Family Family Planning Fathers Febrile Convulsions Fellowship Fellowship Program Female Female of child bearing age Fetal Alcohol Syndrome Fetal Development Fetal Growth Fetal Growth Retardation Fetal Heart Rate Fetus Fingers Fire - disasters First Degree Relative First Pregnancy Trimester Fixatives Floor Flow Cytometry Flowers Fluorescein-5-isothiocyanate Fluorescence Fluorescence Microscopy Fluorescence-Activated Cell Sorting Fluorescent in Situ Hybridization Focal Seizure Folic Acid Follow-Up Studies Food Food Preferences Forelimb Fostering Foundations Fourier Transform Free Radicals Freezing Frequencies Fright Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Funding Future G Protein-Coupled Receptor Genes G-Banding Gas Chromatography Gene Amplification or Deletion Detection Gene Expression Gene Expression Regulation Gene Mutation Gene Proteins Gene Transfer General Population Generations Genes Genetic Genetic Counseling Genetic Medicine Genetic Polymorphism Genetic Predisposition to Disease Genetic Services Genetics and Medicine Genets Genitourinary system Genomic Hybridizations Genomics Genotype Gestational Diabetes Glucuronosyltransferase Glutamate Receptor Glutamates Glutamine Goals Gonadal Steroid Hormones Gossypium Grant Gray unit of radiation dose Growth Guidelines Gynecologic Gynecologic Oncology Group Gynecology HIV HIV Infections Half-Life Hand Head Head circumference Health Health Insurance Portability and Accountability Act Health Personnel Health Professional Health Sciences Health Services Accessibility Health Services Research Health care facility Healthcare Heart Heart Diseases Height Helper Viruses Hematologic Neoplasms Hepatic Hepatitis C Hereditary Disease Hereditary Nonpolyposis Colorectal Neoplasms Herpesvirus Type 3 High Pressure Liquid Chromatography High Prevalence High Risk Woman High-Frequency Ventilation High-Risk Pregnancy Hippocampus (Brain)Hispanics Histologic Histology Histopathology Home environment Homeostasis Homocysteine Homocystine Hormonal Hormones Hospital Units Hospitals Hour House Staffs Housing Human Human Genetics Human Genome Human Herpesvirus 4 Human Milk Human Papillomavirus Human Resources Hydrocortisone Hydroxyprogesterone Hydroxyprogesterone Caproate Hypersensitivity Hypertension Hypertension induced by pregnancy Hypoglycemia Hypotension IACUC Image Image Analysis Imagery Immune Immune system Immunoassay Immunoglobulins Immunohistochemistry Immunologics Immunology Immunosuppressive Agents Impaired cognition Impairment In Situ Hybridization In Situ Nick-End Labeling In Vitro Incidence Income Incubators Individual Industry Infant Infant Development Infant Mortality Infection Infection of amniotic sac and membranes Information Distribution Information Resources Information Retrieval Information Systems Informed Consent Injection of therapeutic agent Inpatients Insecticides Institutes Institution Instruction Insulin Insulin-Dependent Diabetes Mellitus Insurance Intake Intelligence Intensive Care Intensive Care Units Intercept Interest Group Internal Medicine International International Aspects Internet Internist Interphase Intervention Intervention Studies Interview Intracranial Hemorrhages Intrauterine Blood Transfusion Intravenous Invasive Investigation Investigational Drugs Ion Channel Ischemia Isoenzymes Joint Commission on Accreditation of Healthcare Organizations Joint Ventures Joints Journals Karyotype Kidney Kidney Diseases Kindling (Neurology)Kinetics Knowledge Label Labor Complications Laboratories Laboratory Animal Medicine Laboratory Technicians Lactation Language Language Development Laser Scanning Confocal Microscopy Lasers Latina Lead Learning Learning Disabilities Learning Disorders Least-Squares Analysis Left Lesion Letters Levaquin Levetiracetam Licensing Life Life Stress Life Style Ligand Binding Light Limb structure Limbic System Limes Linear Models Linguistics Link Lipids Liquid Chromatography Liquid substance Literature Live Birth Lobbying Localized Location Logistic Regressions Logistics Long-Term Effects Longitudinal Studies Low Birth Weight Infant Lung Magnesium Sulfate Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mails Maintenance Malignant Neoplasms Malignant neoplasm of ovary Malva Manuals Manufacturer Name Maps Marketing Mass Spectrum Analysis Matched Group Maternal Age Measurement Measures Meconium Media Campaign Mediating Mediation Mediator of activation protein Medicaid Medical Medical Care Team Medical Economics Medical Faculty Medical Genetics Medical Records Medical Students Medical Surveillance Medical center Medicine Membrane Membrane Lipids Memory Memory Disorders Mental Retardation Mental Retardation and Developmental Disabilities Research Centers Mental deficiency Mental disorders Mercury Messenger RNA Meta-Analysis Metabolic Metabolism Metaphase Methadone Methodology Methods Metronidazole Microarray Analysis Microbiology Microcephaly Microinjections Microscopy Microtome - medical device Mid-Atlantic Region Milk Minor Minority Mission Mitochondrial DNA Mitochondrial Diseases Modality Modeling Modification Molds Molecular Molecular Biology Molecular Cytogenetics Molecular Diagnosis Molecular Genetics Molecular Models Molecular Profiling Monitor Monkeys Moods Morbidity - disease rate Morphologic artifacts Morphology Morula Mothers Motion Motor Motor Seizures Mouse Strains Movement Multi-Drug Resistance Multi-Institutional Clinical Trial Multicenter Studies Multicenter Trials Multiple Pregnancy Multiple Sclerosis Multivariate Analysis Mus Mutation Mutation Detection Mycoplasma Myelin N(delta)-acetylornithine, -isomer N-Methyl-D-Aspartate Receptors N-Methylaspartate N-acetylaspartate N-dodecanoylglutamic acid, -isomer, sodium salt NCI Scholars Program NTF3 gene Names Nasal bone structure National Cancer Institute National Center for Research Resources National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development National Institute of Mental Health National Institute of Nursing Research Native Hawaiian or Other Pacific Islander Natriuretic Peptides Nature Neonatal Neonatal Intensive Care Units Neonatal Nursing Neonatology Nephrology Nerve Degeneration Nerve Tissue Nervous system structure Neural Tube Closure Neural Tube Defects Neural tube Neuro-Oncological Ventral Antigen 2 Neurocognition Neurocognitive Neurocognitive Deficit Neurodegenerative Disorders Neurodevelopmental Deficit Neurologic Neurologist Neurology Neuronal Plasticity Neurons Neuropharmacology Neuropsychological Tests Neurosciences Neurosecretory Systems Neurotransmitters Neurotrophin 3 New York Newborn Animals Newborn Infant Nitrates Nitric Oxide Noise Non-Steroidal Anti-Inflammatory Agents Nonprofit Organizations Normal Statistical Distribution Normal tissue morphology Nose Nuclear Nucleic Acids Nucleotides Numbers Nurse Midwives Nurse&apos s Role Nurseries Nursery Schools Nurses Nursing Research Nursing Staff Nutritional Nutritionist Obesity Observational Study Obstetrics Departments Occupational Occupational Therapist Occupations Odors Ointments Oligonucleotide Microarrays Onset of illness Ontology Operating Rooms Operative Surgical Procedures Ophthalmologist Oral Oral Administration Organ Transplantation Orthopedic Surgery procedures OspA protein Outcome Outcome Measure Outcome Study Outpatients Output Oxidative Stress Oxides Oxytocin Pain Pain management Pancreatic ribonuclease Paper Paraffin Paralysed Parasites Parasitology Parenting behavior Parents Parietal Parietal Lobe Paris, France Partial Epilepsies Participant Pathologic Pathologist Pathology Patient Care Patient Recruitments Patient currently pregnant Patients Pattern Pediatric Hospitals Pediatric Intensive Care Units Pediatrics Penetration Peptide Sequence Determination Performance Perfusion Perinatal Perinatal Exposure Peripheral Peroxidase Peroxidases Personal Satisfaction Personnel Recruitments Pesticides Pharmaceutical Preparations Pharmacists Pharmacodynamics Pharmacogenetics Pharmacogenomics Pharmacologic Substance Pharmacology Pharmacotherapy Pharmacy facility Phase Phase II Clinical Trials Phase III Clinical Trials Phenobarbital Phenotype Phenytoin Philadelphia Phosphorylation Physicians Physicians&apos Offices Physiological Physiology Pilot Projects Placebo Control Placebo Effect Placebos Placenta Plasma Plasma Proteins Plastic Surgical Procedures Platelet Factor 4 Play Pliability Poland Policies Polymerase Chain Reaction Population Population Characteristics Positioning Attribute Positron-Emission Tomography Post-Translational Protein Processing Postmenopause Postoperative Care Postpartum Period Pre-Eclampsia Predisposing Factor Pregnancy Pregnancy Complications Pregnancy Maintenance Pregnancy Outcome Pregnancy in Adolescence Pregnancy in Diabetics Pregnancy loss Pregnant Women Premature Birth Premature Infant Prematurity of fetus Premenopause Prenatal Diagnosis Prenatal care Preparation Prevalence Prevention Price Primary Health Care Primidone Principal Investigator Printing Privacy Private Practice Probability Problem Solving Procedures Process Production Professional counselor Progesterone Program Research Project Grants Property Prospective Studies Prostaglandins H Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Protease Inhibitor Protein Analysis Protein Binding Proteins Proteomics Proto-Oncogene Proteins c-akt Protocol Association Protocols documentation Protons Psyche structure Psychiatry Psycholinguistics Psychologist Psychopharmacology Psychophysiology Ptosis Public Health Public Policy Publications Publishing Pulmonary Hypertension Pulse Oximetry Pyrrolidines Pyrrolidinones Quality Control Quality of life Quarantine Questionnaires Quetiapine fumarate R-factor RNA Race Radial Radio Radiology Specialty Rain Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Rattus Raven Reaction Reading Reagent Receptor Activation Receptor, Angiotensin, Type 1 Recombinant DNA Recommendation Recording of previous events Records Recovery Room Recruitment Activity Recurrence Reflex action Refractory Registered nurse Registries Regression Analysis Regulation Relative (related person)Relaxation Renal Blood Flow Renal Hypertension Renal function Renin-Angiotensin System Reporting Reproducibility Research Research Activity Research Ethics Committees Research Infrastructure Research Institute Research Methodology Research Misconduct Research Personnel Research Project Grants Research Proposals Research Subjects Research Support Research Training Residual state Resistance Resolution Resource Sharing Resources Respiration Response to stimulus physiology Rest Retrieval Retrospective Studies Retroviridae Rett Syndrome Reversal Learning Review Literature Rheumatology Rhodamine Rhodamines Ribonucleases Rice Risk Risk Factors Risk Management Risk-Benefit Assessment Rodent Role Role playing therapy Route Running Rupture Safety Sample Size Sampling San Francisco Scanning Schedule Schools Science Scientist Scleroderma Score Screening for cancer Screening procedure Seizures Sensory Septo-Optic Dysplasia Series Serious Adverse Event Serum Services Severities Sex Characteristics Sex Discrimination Sheep Short-Term Memory Shoulder Siblings Side Sigmoid colon Sign Language Signal Transduction Signaling Molecule Significance Level Silver Silver Nitrate Silver Staining Simulate Site Skeletal system Skin Small Animal Imaging Systems Small Business Funding Mechanisms Small Business Innovation Research Grant Small Business Technology Transfer Research Smoke Social Development Social Workers Social status Societies Socioeconomic Status Sodium Solid Solutions Source Special Education Specialist Specific qualifier value Specificity Specimen Specimen Handling Spectral Karyotyping Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry Spectrum Analysis Speech Pathologist Speech Therapist Spinal Spinal Dysraphism Spinal cord injury Spontaneous abortion Sprague-Dawley Rats Stable Isotope Labeling Staging Staining method Stains Standards of Weights and Measures Sterile coverings Sterility Steroids Stimulus Stress Stress Tests Stretching Stroke Structural Models Structure Structure of placental cotyledon Students Study Subject Subgroup Substance abuse problem Sum Superoxides Supervision Supplementation Support System Support of Research Surface Suspension substance Suspensions Synapses Syndrome System Systemic Scleroderma T-Lymphocyte Tablets Tacrolimus Tail Task Performances Techniques Technology Teenagers Telemedicine Temperament Temperature Tennis Teratogens Teratology Term Birth Termination of pregnancy Test Result Testing Testosterone Thalamic structure Theophylline Therapeutic Therapeutic Agents Therapeutic Clinical Trial Therapeutic Effect Thick Thinking Third Pregnancy Trimester Thromboxanes Thumb structure Thyroid Hormones Thyrotropin-Releasing Hormone Thyroxine Time Tissue Culture Shared Resource Tissue Culture Techniques Tissue Procurements Tissues Toes Toxic effect Toxicology Tracer Traction Training Training Programs Transcriptional Regulation Transfusion Transgenic Animals Transgenic Organisms Translations Transplant Recipients Transplantation Trauma Treatment Efficacy Treatment Protocols Treatment outcome Triage Trichomonas vaginalis Triiodothyronine Trimethadione Tuberculosis Tumor Biology Tumor Cell Biology Twin Multiple Birth U-Series Cooperative Agreements Ultrasonography Uncertainty United Kingdom United States United States Dept. of Health and Human Services United States Food and Drug Administration United States National Institutes of Health Universities University Hospitals Upper arm Urine Urology Vaginal Birth after Cesarean Validation Valproate Sodium Valproic Acid Variant Vascular Diseases Vascular Endothelial Growth Factors Vasodilator Agents Vasopressins Ventilator Ventricular Vertebrates Very Low Birth Weight Infant Veterinarians Victoria Austrailia Video Microscopy Videotape Vigabatrin Violence Virginia Virulence Virus Virus Diseases Visit Visual Visual attention Visuospatial Vocabulary Test Wages Washington Water Water consumption Weaning Week Weight Western Australia Western Blotting Withdrawal Wolves Woman Women&apos s Health Wood material Work Workplace World Health Organization Writing Zinc deficiency absorption abstracting adrenomedullin age discrimination age related aged alcohol effect alpha-difluoromethyl-DOPA, -isomer alpha-methylornithine dihydrochloride, -isomer aluminum sulfate angiogenesis animal care antimicrobial drug antiretroviral therapy antischizophrenic assay development austin barbituric acid salt base behavior measurement behavior test biosafety level 2 facility blastocyst blind blood glucose regulation bone brain behavior brain metabolism brain volume cancer genetics cancer immunotherapy cancer pharmacology capsule carbamazepine epoxide caudate nucleus cellular transduction charge coupled device camera chemokine chemotherapy child battery cleft lip and palate clinical application clinically relevant clinically significant cognitive function cohort college combinatorial comparative comparative genomic hybridization computer network computerized concept conditioning congenital heart disorder cooperative study cost critical developmental period cross reactivity cytochrome P450 3A cytokine darbepoetin alfa data acquisition data integration data integrity data management day density dentate gyrus design detector developmental disease developmental neurotoxicity diabetic diabetic cardiomyopathy diaries diffusion anisotropy digital digital video recording direct patient care dissemination research dosage drug development drug discovery drug exposure in utero drug metabolism early experience efficacy trial enantiomer enzyme activity executive function expectation experience expression cloning extracellular falls fetal fetal blood fetal drug exposure fetal fibronectin fetal hydantoin syndrome fetal valproate syndrome fluorescence imaging fluorescence microscope folic acid metabolism follow-up fungus gabapentin gallium alloy GF gamma-Aminobutyric Acid gel electrophoresis genetic analysis glycosylation grasp gray matter handbook handicapping condition health care delivery health care quality healthy volunteer hemodynamics hospital bed human disease human embryonic stem cell human fetus tissue human study human subject illness length immune function immunoregulation implementation research improved in utero in vitro Model in vivo indexing infancy inhibitor/antagonist injured instrument instrumentation interest intrapartum ivabradine knowledge base laboratory facility lamotrigine language processing lateral ventricle lead exposure lectures life time cost liver metabolism long term memory luminescence mRNA Expression magnetic resonance spectroscopic imaging male malformation mass spectrometer maternal diabetes mature animal medical complication medical schools member men method development metropolitan microorganism mitochondrial DNA mutation model development models and simulation molecular imaging molecular modeling morris water maze mother nutrition motor deficit motor learning mouse model multidisciplinary named group neonatal exposure neonatal resuscitation neonate nervous system disorder neural circuit neurobehavior neurobehavioral neurochemistry neurodevelopment neuroimaging neuromechanism neuron apoptosis neuron loss neuronal excitability neuropathology neuroprotection neuropsychological neurosurgery neurotoxic neurotoxicity neurotoxicology neurotransmission neurotrophic factor nitrate non-nucleoside reverse transcriptase inhibitors nonhuman primate novel novel therapeutics nutrition oncofetal fibronectin oncology optical disc oral cleft orofacial outreach oxcarbazepine patient oriented pediatric AIDS pediatric department pediatrician peer peptide hormone perinatal health pharmacodynamic model pharmacokinetic model phonology physiologic model placebo controlled study postnatal preference pregabalin pregnancy disorder pregnancy prevention prenatal prenatal exposure prescription document prescription procedure preterm premature rupture of membranes prevent professor progesterone 11-hemisuccinate-(2-iodohistamine)programs prospective protein expression protein function protein structure function protocol development psychoeducational psychologic pup pyrrolidine quality assurance racial and ethnic randomized placebo controlled trial ranpirnase rapid detection receptor regional difference relating to nervous system repository reproductive research facility research study resistance factors respiratory response restraint sex simulation size skills social socioeconomics software systems solute somatosensory stable isotope statistics steroid hormone stillbirth stressor success symposium synaptogenesis syntax tandem mass spectrometry teacher tertiary care time use tissue culture tissue processing tomography tool trait transmission process trauma centers treatment trial tumor tumor growth tumorigenesis tv watching type I and type II diabetes uptake urinary vaccine evaluation validation studies valproate visual motor visual process visual processing visual stimulus visual-motor integration voltage web interface white matter whole body imaging

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DESCRIPTION (provided by applicant): The Washington Obstetric Pharmacology Research Unit (WOPRU) represents a collaboration among two universities and four medical centers in the nation's capitol that is uniquely positioned to use population pharmacokinetic, pharmacokinetic-pharmacodynamic, clinical trials simulation, cutting edge in vivo and in vitro techniques to assess clinical pharmacology of important therapeutic agents and their effects in pregnant women and their offspring. Specifically, the WOPRU combines the basic research resources of Georgetown University (GU) (lead agency) and George Washington University (GWU) with the clinical strengths of MedStar Health (Washington Hospital Center [WHC] and Georgetown University Hospital [GUH]), GWU Hospital, and Children's National Medical Center (CNMC). Our hospitals are strategically placed throughout the DC metropolitan area, and are closely associated with the respective surrounding communities. The WOPRU obstetricians deliver over 7,000 babies from women who represent a broad spectrum of social, economic, ethnic, racial and cultural backgrounds with a large proportion of these pregnancies being high risk. The WOPRU institutions have an excellent track record of providing care and recruiting patients into clinical trials from our diverse community. The faculty of the WOPRU represent a team of highly motivated basic scientists and clinical investigators who are enthusiastically approaching the prospect of becoming a new center for OPRU. They are experienced investigators in a multitude of basic science and clinical disciplines with a unique combination of strengths in pharmacometrics, pharmacodynamics, pharmacogenetics, drug metabolism, therapeutic drug monitoring, proteomics, genomics and biostatistics in conjunction with significant experience in multi-center clinical trials. The administration, and the basic science and clinical investigators of the WOPRU institutions are unanimous in their eagerness to support and participate in the future OPRU network.

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