Arkansas Center for Food Allergy Research (ArCOFAR)

项目摘要 食物过敏是一种具有全球影响的疾病，与危及生命的反应有关，患病率不断增加， 治疗和预防的选择有限。尽管研究取得了重大进展，但仍有许多人 在全球实施有效的治疗和预防方案之前，必须解决这些问题， 可以实现对食物过敏患者的治疗。食物过敏研究联盟（CoFAR） 通过其临床研究合作研究网络， 具有食物过敏临床试验经验和专业知识的单位（CRU）。为此，阿肯色州中心 食物过敏研究（ArCOFAR）建立在超过30年的卓越，专业知识和领导力的基础上 在食物过敏，并准备立即解决的总体计划目标的CoFAR。的 通过我们广泛的研究贡献，ArCOFAR工厂处于理想的位置，可以作为CoFAR CRU发挥作用 经验，并利用我们人口的独特地理和病人的人口特征。 我们的努力将以核心假设为指导，即ArCOFAR将使不同的人能够参与， 在专业设计的最高质量的创新临床试验中， 和科学价值。我们的总体目标是提供一个独特的研究平台，以可衡量地提高 食物过敏儿童和成人的生活。这一目标将通过设计和 通过高质量、高影响力的研究实施创新的临床研究和治疗试验 协作我们的假设将通过执行四个具体目标进行测试：1）利用现有的专业知识 在食物过敏研究中，作为扩大免疫治疗临床试验开发的平台， 与其他CoFAR CRU整合研究工作; 2）应用机构和社区资源， ArCOFAR CRU食物过敏人群研究能力，包括参与出生队列研究 3）将现有的机构间和机构内资源联系起来， 参与临床研究，包括更多样化的食物过敏患者人群; 4）促进职业发展 通过积极招募和指导新的和早期职业食物过敏研究人员， 教师和链接既定的方案和网络资源。此外，我们的尖端临床试验 核桃口服免疫疗法将解决一个未满足的需要，在管理树坚果过敏。此外，本发明还 ArCOFAR的多学科团队在食物过敏方面拥有成熟的专业知识和国际领导地位 临床试验，将通过开发和测试新型免疫治疗药物来扩大临床研究 和实施队列研究，同时为早期 和新的职业调查员这一建议的结果将是改善儿童和成人的健康 在阿肯色州及其他地区的食物过敏患者中，同时推进CoFAR的使命，从根本上改变 食物过敏领域。

PROJECT SUMMARY Food allergy is a disease of global impact associated with life-threatening reactions, increasing prevalence, and limited options for treatment and prevention. Despite significant research advances, many remaining questions must be addressed before global implementation of impactful therapeutic and prevention options for patients affected by food allergy can be realized. The Consortium for Food Allergy Research (CoFAR) was formed to address these unresolved questions through its collaborative research network of Clinical Research Units (CRU) with experience and expertise in food allergy clinical trials. To this end, the Arkansas Center for Food Allergy Research (ArCOFAR) builds on a >30 year foundation of excellence, expertise, and leadership in food allergy and is prepared to immediately address the overarching program goals of CoFAR. The ArCOFAR site is ideally-positioned to function as a CoFAR CRU through contribution of our extensive research experience and by capitalizing on our population's unique geographic and patient demographic characteristics. Our efforts will be directed by the central hypothesis that ArCOFAR will enable the participation of diverse groups of food allergic individuals in expertly designed, innovative clinical trials of the highest quality and scientific value. Our overarching goal is to provide a unique research platform to measurably improve the lives of children and adults with food allergy. This goal will be accomplished by the design and implementation of innovative clinical studies and therapeutic trials via high-quality, high-impact research collaboration. Our hypothesis will be tested by executing four specific aims: 1) Leverage established expertise in food allergy research as a platform to expand clinical trials development in immunotherapeutics through integrated research efforts with other CoFAR CRUs; 2) Apply institutional and community resources to expand ArCOFAR CRU capacity for population-based research in food allergy, including participation in birth cohort and longitudinal outcome studies; 3) Link current inter- and intra-institutional resources to broaden the scope of clinical research participation to include a more diverse population of food allergic patients; 4) Promote career development of new and early career food allergy researchers through active recruiting and mentoring of new faculty and linking established programmatic and network resources. In addition, our cutting-edge clinical trial of walnut oral immunotherapy will address an unmet need in management of tree nut allergy. Further, ArCOFAR's multi-disciplinary team with established expertise and international leadership in food allergy clinical trials, will expand clinical research through the development and testing of novel immunotherapeutics and implementation of cohort studies, while providing mentoring and career development opportunities to early and new career investigators. The outcome of this proposal will be to improve the health of children and adults with food allergy in Arkansas and beyond while advancing the mission of CoFAR to fundamentally change the field of food allergy.