The Effectiveness and Cost-Effectiveness of Implementing Evidence-Based Depression Treatment within the TB Care Platform in South Africa: A Hybrid Effectiveness-Implementation Trial

项目摘要 我们建议为Ernesha Webb Mazinyo博士提供多样性补充，为她提供适当的环境， 培训，个性化的指导和研究经验，以启动她的职业生涯作为一个独立的- 资助的执行科学家。为了实现这一目标，Webb Mazinyo博士将接受指导， 研究支持，传播和实施科学（D&I）的教学课程，实践研究 经验，包括主要数据收集和混合方法分析，并协助撰写补助金， 手稿准备。Webb Mazinyo博士将由Annika Sweetland（PI），Andrew Medina博士指导- Marino（研究中心PI，Co-I）和米尔顿温伯格（Co-I），在她从事D&I研究时提供建议，重点是 将结核病、抑郁症和危险饮酒（HD）治疗纳入初级保健。斯威特兰医生麦迪纳医生 Marino和Wainberg在D&I科学和混合方法研究方面具有相关的方法学专业知识; 关于结核病、抑郁症和HD交叉点的专题专业知识;以及早期成功的跟踪记录指导 investigators.此应用程序通过将科学范围扩展到包括HD，建立在家长研究的基础上 有抑郁症和无抑郁症的结核病患者之间的差异。Webb Mazinyo博士将参加所有研究活动 与母研究相关的工作，包括编写和提交科学论文/提案，沿着 教学和职业发展活动。Webb Mazinyo博士的实践研究将包括两项研究 目的： 目的1：利用母研究数据估计结核病中HD的患病率和社会相关性 患有和不患有抑郁症的患者。 目的2：调查整合治疗的背景因素和潜在障碍/促进因素， 结核病治疗平台内的抑郁症和HD。 总而言之，为该多样性补充提出的研究活动将开发Webb Mazinyo博士的 D&I研究技能，并将提供所需的结构和支持，使她成为一个非常成功的 独立研究人员能够解决南非结核病患者HD治疗的整合问题， 其他低资源配置。我们的主要目标是支持Webb Mazinyo博士申请并获得K 01 该奖项旨在支持她成为D&I领域最高水平的研究人员的目标。

PROJECT SUMMARY We propose a Diversity Supplement for Dr. Ernesha Webb Mazinyo to provide her the appropriate setting, training, individualized mentoring and research experience necessary to launch her career as an independently- funded implementation scientist. In order to achieve this goal, Dr. Webb Mazinyo will receive mentoring and research support, didactic coursework in dissemination and implementation science (D&I), hands-on research experience including primary data collection and mixed-methods analysis, and assistance with grant writing and manuscript preparation. Dr. Webb Mazinyo will be mentored by Drs. Annika Sweetland (PI), Andrew Medina- Marino (site-PI, Co-I) and Milton Wainberg (Co-I), to advise her as she pursues D&I research focused on integrating TB, depression and hazardous drinking (HD) treatment within primary care. Drs. Sweetland, Medina- Marino, and Wainberg have relevant methodological expertise in D&I science and mixed-methods research; topical expertise on the intersection of TB, depression and HD; and a successful track-record mentoring early investigators. This application builds upon the parent-study by expanding the scientific scope to include HD among TB patients with and without depression. Dr. Webb Mazinyo will participate in all research activities related to the parent study, including the preparation and submission of scientific papers/proposals, along with didactic and career development activities. Dr. Webb Mazinyo’s hands-on research will include two research aims: AIM 1: To leverage parent study data to estimate the prevalence and social correlates of HD among TB patients with and without depression. AIM 2: To investigate contextual factors and potential barriers/facilitators to integrating treatment for depression and HD within the TB care platform. Taken together, the research activities proposed for this Diversity Supplement will develop Dr. Webb Mazinyo’s D&I research skills and will provide the structure and support needed for her to become a highly successful independent researcher able to address integration of treatment for HD for patients with TB in South Africa and other low-resource settings. Our main objective is to support Dr. Webb Mazinyo to apply for and obtain a K01 award to support her goal of becoming a researcher of the highest caliber in the field of D&I.