SPF 4 Rhesus Macaque Breeding Colony for AIDS Research

项目总结，总体 安全、有效的疫苗仍然是控制人类免疫缺陷病毒的最大希望 (艾滋病毒)大流行。由于起源于印度的恒河猴(Macaca Mulatta)与人类之间的相似性 免疫系统、疫苗开发以及其他控制艾滋病的方法在很大程度上 依赖于SIV和SHIV猕猴模型。对印度原产恒河猴的需求仍在持续 猕猴来支持这项工作。旨在高效生产的国内育种计划 为了确保生物医学研究的供应，印度血统的恒河猴是必要的 艾滋病疫苗开发和治疗所需的科目，以及发病机制研究。目的 这项提议是为了支持具有遗传特征的、无特定病原体的、印度血统的恒河猴 2001年在俄勒冈州国家灵长类动物中心建立的猕猴艾滋病研究群体资源 研究中心。

PROJECT SUMMARY, Overall A safe, effective vaccine continues to be the best hope for controlling the Human Immunodeficiency Virus (HIV) pandemic. Due to similarities between the Indian-origin rhesus macaque (Macaca mulatta) and human immune systems, vaccine development, as well as other approaches for controlling AIDS, are heavily dependent upon the SIV and SHIV macaque models. There is a continuing need for Indian-origin rhesus macaques to support this work. Domestic breeding programs that are designed to efficiently produce well characterized Indian-origin rhesus macaques are necessary to ensure the supply of biomedical research subjects required for AIDS vaccine development and treatments, and pathogenesis studies. The purpose of this proposal is to provide support for the genetically characterized, specific pathogen free, Indian-origin rhesus macaque AIDS Research Colony resource that was established in 2001 at the Oregon National Primate Research Center.