Animal Physiology Core

动物生理学核心（APC）提供由Habegger博士监督的全面服务， 三个副主任，并结合了高水平的专业知识，在综合生理学，葡萄糖 稳态，线粒体代谢和氧化还原生物学，以及作为研究核心资源的动物模型 糖尿病和心脏代谢疾病的风险。APC的目标是为高度专业化的 设备，技术和身体组成，能量学，葡萄糖稳态领域的专业知识， 心血管评估、成像、转基因动物模型和技术，以增加糖尿病 研究能力、质量和成本效益。 核心的具体目标是： 1.提供使用糖尿病研究动物模型的专业知识; 2.提供最先进的仪器和方法来确定：身体 组成，能量消耗和平衡，底物代谢，葡萄糖稳态，胰岛素 敏感性和分泌，线粒体和细胞代谢，氧化和激素应激，以及 转基因动物模型。 3.为核心用户提供具有成本效益的服务;以及 4.促进研究者之间的互动，并提供动物模型方面的培训， 表型分析方法 自APC于2008年与刚果民主共和国成立以来，其利用率和生产率的记录一直是 杰出的，正在成长。核心技术的高质量、广度和尖端性，以及 对我们调查人员不断变化的需求的响应，导致了DRC的高利用率 研究基地。通过传播小动物表型分析的高质量服务，核心是一个重要的 确保研究在整个转化研究领域得到促进的力量。的 核心利用率表中的生产率数字和数据本身就说明了问题。在上一个赠款周期， APC一直非常积极地支持来自154名糖尿病研究人员的210个资助项目。 research.此外，该中心提供的数据成为许多联邦赠款的基础，并导致许多 高质量的出版物。

The Animal Physiology Core (APC) provides a comprehensive array of services overseen by Dr. Habegger with three Associate Directors and incorporates a high level of expertise in the areas of integrative physiology, glucose homeostasis, mitochondrial metabolism and redox biology, and animal models as a core resource for the study of diabetes and cardiometabolic disease. The goal of the APC is to provide easy access to highly-specialized equipment, technology, and expertise in the area of body composition, energetics, glucose homeostasis, cardiovascular assessment, imaging, and transgenic animal models and technology to augment diabetes research capacity, quality, and cost effectiveness. The Specific Aims of the Core are: 1. To provide expertise in the use of animal models for diabetes research; 2. To provide state-of-the-art instrumentation and methodology for the determination of: Body composition, Energy expenditure and balance, Substrate metabolism, Glucose homeostasis, Insulin sensitivity and secretion, Mitochondria & Cellular Metabolism, Oxidative & Hormonal Stress, and the generation of Genetically modified animal models. 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the APC was founded with the DRC in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By disseminating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active supporting 210 funded projects from 154 investigators conducting diabetes research. Moreover, the data provided by the core became the basis of numerous federal grants and led to many high-quality publications.