Mouse Core

糖尿病及其并发症的啮齿动物模型提供了对糖尿病及其并发症的分子基础的基本见解。 人类疾病哥伦比亚糖尿病研究中心（DRC）的研究人员雇用了一名以上的 研究糖尿病及其相关疾病的发展、病理和并发症 紊乱研究啮齿动物糖尿病的现代工具和对小鼠的实验操作通常需要 昂贵的设备和技术技能超出了个别调查人员的能力。鼠标 代谢功能和表型核心（MMFPC）为DRC提供高效，经济，及时的服务 调查员，使研究人员能够进行实验，否则将超出他们的能力。 在目前的供资周期内，对小额供资和微型企业融资方案的需求很大，自2004年以来，该方案已发生了重大变化。 最后一次提交，以满足刚果民主共和国调查人员不断变化的需求。MMFPC已被证明是广泛成功的 在实现其使命，协助个别研究人员在表征代谢表型的小鼠。 MMFPC目前提供四种广泛的服务，促进小鼠的有效表征 糖尿病及其并发症的模型：（i）身体成分分析，（ii）全身代谢 评估，（iii）代谢夹，和（iv）代谢程序和surgery。一项用于隔离和 表征细胞外囊泡正在实施，暂定开始日期为2022年7月。MMFPC 这些服务是对其他DRC核心提供的服务的补充，因此， 资源可以充分表征小鼠的组织学、免疫学和代谢功能和表型。 核心已经建立了通过娜奥米贝里糖尿病中心和哥伦比亚的大力支持 大学为了响应调查员的调查，自我们上次竞争续约以来，我们现在提供一套 有助于研究糖尿病发展和病理生理学的外科手术。预测 这表明，随着我们加强和发展研究基础，对核心服务需求将继续保持高水平。

Rodent models of diabetes and its complications provide fundamental insights into the molecular basis of human disease. The investigators of the Columbia Diabetes Research Center (DRC) employ more than one hundred murine models to study the development, pathology and complications of diabetes and related disorders. Modern tools to study diabetes in rodents and experimental manipulation of mice often requires expensive equipment and technical skills that are beyond the means of individual investigators. The Mouse Metabolic Function & Phenotyping Core (MMFPC) provides efficient, cost-effective, and timely services to DRC investigators that enables researchers to carry out experiments that otherwise would be beyond their ability. The MMFPC has been in great demand during the current funding cycle and has evolved significantly since the last submission to meet the changing needs of DRC investigators. The MMFPC has proven broadly successful in achieving its mission of assisting individual investigators in characterizing metabolic phenotypes of mice. The MMFPC currently provides four broad services that facilitate the efficient characterization of mouse models of diabetes and its complications: (i) Body Composition Analysis, (ii) Whole Body Metabolic Assessment, (iii) Metabolic Clamps, and (iv) Metabolic Procedures & Surgeries. A service to isolate and characterize extracellular vesicles is being implemented with a tentative start date of July 2022. The MMFPC services complement those provided by other DRC Cores, so that investigators who take advantage of DRC resources can fully characterize the histologic, immunologic, and metabolic function and phenotype of mice. The Core has been built through the strong support of the Naomi Berrie Diabetes Center and Columbia University. In response to investigator surveys and since our last competing renewal, we now provide a suite of surgical procedures that will facilitate studies of the development and pathophysiology of diabetes. Projections indicate that demand for Core services will remain high as we strengthen and grow our research base.