Mouse Metabolic Measurement System

小鼠代谢表型分析系统 摘要 代谢评估是许多疾病的鼠模型研究的核心，包括经典的代谢评估。 糖尿病、肥胖症和厌食症，但代谢谱在研究中越来越重要， 动脉粥样硬化、脂肪肝、癌症以及最近在自身免疫性疾病、衰老和 发展哥伦比亚大学欧文医学中心（CUIMC）一直是研究 在疾病和生理学的小鼠模型中的代谢的研究已经超过二十年。研究的成功 哥伦比亚大学教师的努力一直以建立和维护科学基础设施为基础， 允许科学家对小鼠的代谢表型进行最先进的评估， 重点、专门知识和资源。Naomi Berrie糖尿病中心在建设这一基础设施方面发挥了重要作用 美国国立卫生研究院资助的糖尿病、癌症和肥胖症项目帮助员工和维护各种设施。 此应用程序建议通过购买Sable来维护该基础架构并增强其功能 用于小鼠研究的异丙嗪代谢表型分析系统。该系统将允许高时间分辨率 在评估代谢功能（O2消耗和CO2产生）、运动、水摄入、运动 进食行为、体重以及附加传感器体温和连续葡萄糖监测。 16笼系统将以集成形式提供最先进的技术，具有灵活性， 由其他系统提供。该系统将由Anthony Ferrante博士监督，并将纳入 现有的基础设施由Naomi Berrie、哥伦比亚糖尿病和纽约营养肥胖支持 研究中心。它将取代一个过时的系统，目前没有运行，并将扩大能力， 一大批富有成效的哥伦比亚研究人员完成资助的建议，并提供新的 进一步代谢研究的机会。

Mouse Metabolic Phenotyping System Abstract Metabolic assessment is central to the study of many murine models of disease including classic metabolic disorders diabetes, obesity and anorexia, but metabolic profiling has increasing proven important in the study of atherosclerosis, fatty liver disease, cancer and more recently in the study of autoimmune disorders, aging and development. Columbia University Irving Medical Center (CUIMC) has been a leading center for the study of metabolism in murine models of disease and physiology for more two decades. The success of the research efforts by Columbia faculty has been anchored by the building and maintenance of a scientific infrastructure that permits state-of-the art assessment of metabolic phenotypes of mice by scientists with widely varying areas of focus, expertise and resources. The Naomi Berrie Diabetes Center has been central in building this infrastructure and NIH-funded programs in Diabetes, Cancer and Obesity have helped staff and maintain the varied facilities. This application proposes to maintain that infrastructure and grow its capabilities with the purchase of a Sable Promethion Metabolic Phenotyping System for the study of mice. The system will permit high temporal resolution in assessment of metabolic function (O2 consumption and CO2 production), motion, water intake, movement, feeding behavior, body weight and with additional sensors body temperature and continuous glucose monitoring. The 16 cage system will provide state-of-the-art technology in an integrated format with flexibility that is not offered by other systems. The system will be overseen by Dr. Anthony Ferrante and be incorporated into the existing infrastructure supported by the Naomi Berrie, the Columbia Diabetes and the NY Nutrition Obesity Research Centers. It will replace an antiquated system that currently is not operating and will expand the ability of a large group of productive Columbia investigators to complete funded proposals and provide new opportunities for further metabolic studies.