Mouse Metabolic Measurement System

小鼠代谢表型系统 摘要 代谢评估是包括经典代谢在内的许多小鼠疾病模型研究的核心 糖尿病、肥胖症和厌食症，但代谢谱在研究糖尿病、肥胖和厌食症中越来越重要 动脉粥样硬化、脂肪肝、癌症，以及最近对自身免疫性疾病、衰老和 发展。哥伦比亚大学欧文医学中心(CUIMC)一直是研究糖尿病的领先中心 二十多年来小鼠疾病和生理模型中的新陈代谢。这项研究的成功 哥伦比亚大学教职员工的努力建立和维护了一个科学基础设施， 允许科学家对小鼠的代谢表型进行最先进的评估，这些科学家拥有广泛不同的领域 专注、专业知识和资源。内奥米·贝里糖尿病中心一直是建设这一基础设施的核心 NIH资助的糖尿病、癌症和肥胖症项目帮助工作人员和维护各种设施。 此应用程序建议通过购买紫貂来维护该基础架构并扩展其功能 扑灭净代谢表型系统用于小鼠的研究。该系统将允许高时间分辨率 在评估代谢功能(氧气消耗和二氧化碳产生)时，运动、水分摄入量、运动、 摄食行为、体重，并配有额外的传感器、体温和连续血糖监测。 16框架系统将以集成格式提供最先进的技术，具有前所未有的灵活性 由其他系统提供。该系统将由Anthony Ferrante博士监督，并纳入 由Naomi Berrie、哥伦比亚糖尿病和纽约营养肥胖症支持的现有基础设施 研究中心。它将取代目前不运行的过时系统，并将扩展能力 哥伦比亚大学一大群富有成效的调查人员完成资助的提案并提供新的 进一步新陈代谢研究的机会。

Mouse Metabolic Phenotyping System Abstract Metabolic assessment is central to the study of many murine models of disease including classic metabolic disorders diabetes, obesity and anorexia, but metabolic profiling has increasing proven important in the study of atherosclerosis, fatty liver disease, cancer and more recently in the study of autoimmune disorders, aging and development. Columbia University Irving Medical Center (CUIMC) has been a leading center for the study of metabolism in murine models of disease and physiology for more two decades. The success of the research efforts by Columbia faculty has been anchored by the building and maintenance of a scientific infrastructure that permits state-of-the art assessment of metabolic phenotypes of mice by scientists with widely varying areas of focus, expertise and resources. The Naomi Berrie Diabetes Center has been central in building this infrastructure and NIH-funded programs in Diabetes, Cancer and Obesity have helped staff and maintain the varied facilities. This application proposes to maintain that infrastructure and grow its capabilities with the purchase of a Sable Promethion Metabolic Phenotyping System for the study of mice. The system will permit high temporal resolution in assessment of metabolic function (O2 consumption and CO2 production), motion, water intake, movement, feeding behavior, body weight and with additional sensors body temperature and continuous glucose monitoring. The 16 cage system will provide state-of-the-art technology in an integrated format with flexibility that is not offered by other systems. The system will be overseen by Dr. Anthony Ferrante and be incorporated into the existing infrastructure supported by the Naomi Berrie, the Columbia Diabetes and the NY Nutrition Obesity Research Centers. It will replace an antiquated system that currently is not operating and will expand the ability of a large group of productive Columbia investigators to complete funded proposals and provide new opportunities for further metabolic studies.