Instrumentation, Fabrication, and Design Core

视觉科学仪器与制造核心资源， 罗纳德·西尔弗曼，核心总监 摘要/摘要 核心的长期目标是为视觉研究提供机械设计和制造支持 哥伦比亚大学，特别是拥有RO1补助金的调查人员和年轻调查人员为他们的 第一个成功的RO1。最先进的视觉研究依赖于新技术的发展 技术和现有技术的改进。酷睿支持一台特殊的专用机器 商店和一个机械师。因为商店是内部的，机械师熟悉视觉的要求 与大学或商业机构相比，研究、设计新设备的效率更高 商店。核心有四个具体目标：1)设计和制造视觉所需的定制设备 研究，包括系统神经科学、视力研究和眼科学。2)提供紧急情况 对目前用于视觉研究的设备进行维修和改造。3)培养学生和 博士后以最有效的方式与仪器设计者合作。4)鼓励 视觉研究人员之间的合作，让他们分享可能成为 用于多个实验室。这对系统神经科学视觉研究尤其重要，在 类似的设备被用来回答截然不同的科学问题。仪器设计中的协作 经常导致科学合作。Core制造用于系统神经科学的标准设备 例如录音室、灵长类座椅和栅栏。尽管其中一些设备是可用的 在商业上，由Core制造的产品要耐用得多。自定义设备的示例 核心是安装在笼子上的行为训练系统，在它们的家中训练猴子，而不是使用 吊装时间；一种将猴子椅抬到笼口以便于从笼子转移到笼子的系统 椅子；用于研究大鼠眼睛血流的三维超声探头操纵器。这个现已成功的原型 将被扩大到用于人类。

Instrumentation and Fabrication Core Resource for Vision Sciences, Ronald Silverman, Core Director Summary/Abstract The long-term goal of the Core is to provide mechanical design and fabrication support for vision research at Columbia, especially that of investigators with RO1 grants and young investigators gathering data for their first successful RO1s. State-of-the-art vision research is dependent upon the development of new technology and the improvement of current technology. The Core supports a specially dedicated machine shop and one machinist. Because the shop is in-house, and the machinist is familiar with demands of vision research, designing new equipment is far more efficient than it would be with a University or commercial shop. The core has four specific aims: 1)To design and build custom equipment necessary for vision research, both systems neuroscience vision research and ophthalmic science. 2)To provide emergency repairs and modifications for equipment currently in use for vision research. 3)To train students and postdoctoral fellows in the most effective ways to collaborate with instrument designers. 4)To encourage collaboration among vision research investigators, having them share ideas for new devices that might be used in multiple laboratories. This is especially important for systems neuroscience vision research, where similar equipment is used to answer vastly different scientific questions. Collaboration in instrument design has often led to scientific collaboration. The Core builds the standard devices used for systems neuroscience such as recording chambers, primate chairs and grids. Although some of these devices are available commercially, the ones built by the Core are far more durable. Examples of custom equipment built by the Core are cage mounted behavioral training systems to train monkeys in their home cage rather than using rig time; a system for lifting a monkey chair to the cage opening to facilitate transfer from the cage to the chair; a 3D ultrasound probe manipulator for blood flow studies in rat eyes. This now successful prototype will be expanded for use in humans.