Modern approach to electrical conductivity mapping of spinal cord tissues

项目摘要 每年有30,000多名患者接受脊髓电刺激(神经调节)作为一种治疗手段 疼痛管理。然而，优化输送参数是困难的，部分原因是 关于脊髓组织电导率的有价值但不完整的数据集。我们追踪了他的血统 现代大多数电刺激模型对脊髓组织的电导源都是单一的 来源： 兰克1965年。Ranck 1965年内的实验只提供了两种类型的数据：(1)大量脊柱组织 5、50、500和5k赫兹的电导率；和(2)5-10的小体积(8mm3)背柱组织电导率 赫兹。由于脊髓细胞在整个脊髓中的分布并不均匀，因此大块的脊髓组织 导电性扫描不能为不同的电学模型提供足够的空间信息 脊髓的切片、层和组织类型。我们的项目旨在显著改进Ranck 1965 通过获得10-1M赫兹、大体积(40厘米~3)、多方向的电磁电导率数据 使用电子控制的电导探头阵列模拟神经调节。根据我们的发现， 神经学家、神经调节研究人员和设计师将能够提供更有针对性的治疗方法 作为一个更详细和更严格的电磁脊髓模型的结果。

Project Summary Over 30,000 patients per year receive electrical stimulation of the spinal cord (neuromodulation) as a means of pain management. However, optimizing the delivery parameters is difficult, partly because of an extremely valuable but incomplete dataset on the electrical conductivity of spinal cord tissues. We traced the lineage of the spinal tissue electrical conductivity sources of the majority of modern electrostimulation models to a single source, Ranck 1965. The experiments within Ranck 1965 only provided two types of data: (1) bulk spinal tissue conductivity at 5, 50, 500, and 5k Hz; and (2) small volume (8 mm3) of dorsal column tissue conductivity at 5-10 Hz. Since the distribution of spinal cord cells throughout the cord is not uniform, the bulk spinal tissue conductivity sweep does not provide enough spatial information for a detailed electrical model between different sections, layers, and tissue types of the spinal cord. Our project seeks to significantly improve on Ranck 1965 by obtaining 10-1M Hz, large-volume (40 cm3), and multi-directional conductivity data for electromagnetic modeling of neuromodulation using an electronically-controlled conductivity probe array. With our findings, neuroscientists and neuromodulation researchers and designers will be able to provide more targeted therapies as a result of a more-detailed and rigorous electromagnetic spinal cord model.