Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR

项目摘要 PET和MRI提供了生理学的互补视图，并能够测量来自两种模式的数据 同时提供了一个独特的机会，研究生物机制的方式，迄今为止， 这在完整的动物身上是不可能实现的，包括人类。然而，这种硬件和数据的进步 采集对数据分析和解释提出了新的挑战，因为这些模式 基于不同的物理原理，通常反映不同的体内现象。从概念上讲，我们 通过集成的PET/MR分析框架解决问题并抓住机会， 生理机制在数学上将定量PET和MR模型联系起来，提高了准确性， 生理测量的精确度，并且在某些情况下，允许使用 或者单独使用。这种一般的方法提出了几个具体的和说明性的发展 病例-神经传递，线粒体膜电位和氧化应激-一起跨越 不同的器官系统，生理过程和潜在的疾病应用。

Project Summary PET and MRI offer complementary views of physiology and the ability to measure data from both modalities concurrently provides a unique opportunity to study biological mechanisms in ways that were heretofore impossible to realize in intact animals, including human subjects. However, this advance in hardware and data acquisition poses new challenges for data analysis and interpretation due to the fact that the modalities are based upon different physical principles and generally reflect different in vivo phenomena. Conceptually, we address the problem and seize the opportunity via integrated PET/MR analysis frameworks wherein shared physiological mechanisms mathematically link quantitative PET and MR models, improving the accuracy and precision of physiological measurements and, in several instances, permitting outcomes not achievable using either modality alone. This general approach is proposed for development in several specific and illustrative cases – neurotransmission, mitochondrial membrane potential, and oxidative stress – that together span diverse organ systems, physiological processes, and potential disease applications.