Core 1: Administrative Core

Swan-Aging旨在确定中年健康和更年期过渡(MT)的特征对女性成功老龄化的影响程度，包括认知减退率以及痴呆症和残疾的风险。关于老龄化的研究强调中年(40-65岁)是预防认知障碍、阿尔茨海默病、阿尔茨海默病相关痴呆、身体残疾和老年多种疾病的关键人生阶段。这项U19提案将把全国妇女健康研究(SWAN)的后续行动延长到老年早期(66-75岁)，这是一项始于1994年的纵向研究，旨在描述MT期间发生的生理和心理社会变化。它将扩大数据收集范围，将中年健康特征和可修改的风险因素与早期和快速的认知能力下降、轻度认知障碍的发生率、心脏健康和老年早期的身体功能联系起来。Swan-Aging将利用现有的Swan科学专业知识和组织结构创建三个综合项目。项目1将评估MT特征和中年健康指标对认知功能(避免认知功能衰退和轻度认知障碍的发生)、睡眠、泌尿生殖和性功能以及老年早期生活质量的影响；项目2将测试MT与女性早年心脏健康和心血管疾病(CVD)事件的关系，并测试心脏健康与生命关键时期身体损害、阿尔茨海默病和血管性痴呆的早期标记物之间的关系；以及项目3将研究MT和中年特征对肌肉骨骼健康和身体功能的作用。行政核心(核心1)的具体目标是：1)为天鹅老化提供领导、战略规划和组织基础设施；2)促进调查人员的互动、创造力和生产力；3)传播天鹅和天鹅老化结果并加强翻译；4)确保广泛使用天鹅数据并支持职业发展；以及5)监测和保护参与者的安全。核心1将协调和支持跨项目和核心的研究工作，并将提供执行研究业务所需的资源。核心1将支持一个综合科学委员会，该委员会将促进对认知、心脏和身体功能之间的相互关系及其对日常生活残疾活动的联合影响的交叉调查。核心1还将领导一个新的翻译和传播委员会，妇女健康专家将在该委员会中制定方法，传播严格的研究成果，重点是加强临床和非临床社区的身体健康以及预防痴呆症和残疾。行政核心将提供天鹅老龄化项目成功进行研究所需的结构，产生有意义的研究结果，并转化临床相关研究结果，以促进确定中年预防目标，以延迟或避免轻度认知障碍，保持功能，保持独立性，并优化早年生活质量。

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. Studies on aging highlight the midlife (age 40-65 years) as a critical life stage for prevention of cognitive impairment, Alzheimer’s disease, Alzheimer’s disease related dementia, physical disability and multi-morbidity in old age. This U19 proposal will extend follow-up of the Study of Women’s Health Across the Nation (SWAN), a longitudinal study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT, into early old age (66-75 years). It will expand data collection to link midlife health characteristics and modifiable risk factors to early and rapid cognitive decline, incidence of mild cognitive impairment, cardiac health, and physical function in early old age. SWAN-Aging will leverage the existing SWAN scientific expertise and organizational structure to create three integrated Projects. Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of the MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Administrative Core (Core 1) are to: 1) Provide leadership, strategic planning, and organizational infrastructure for SWAN-Aging; 2) Facilitate investigator interaction, creativity, and productivity; 3) Disseminate SWAN and SWAN-Aging results and enhance translation; 4) Ensure broad use of SWAN data and support career development; and 5) Monitor and protect participant safety. Core 1 will coordinate and support research efforts across the Projects and Cores and will supply the required resources to execute study operations. Core 1 will support an Integrative Sciences Committee that will facilitate cross-cutting investigations of the interrelationships between cognitive, cardiac, and physical function, and their joint impact on activities of daily living disability. Core 1 will also lead a new Translation and Dissemination Committee in which experts in women’s health will develop methods for disseminating rigorous research results focused on the enhancement of physical health and the prevention of dementia and disability for clinical and lay communities. The Administrative Core will provide the structure required for the SWAN-Aging Projects to successfully conduct their studies, produce meaningful research results, and translate clinically relevant findings to facilitate identification of midlife prevention targets to delay or avoid mild cognitive impairment, preserve functioning, maintain independence, and optimize quality of life in early old age.