Core 3: Data Collection & Data Management Core

核心 3：数据收集

• 批准号: 10471455
• 负责人: Maria Mori Brooks
• 金额: $ 355.33万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471455
• 关键词: Affect; Aging; Alzheimer' s Disease; Archives; Cardiac; Cardiac health; Cardiovascular Diseases; Characteristics; Clinical; Clinical Data; Cognition; Cognitive; Cognitive deficits; Collection; Data; Data Collection; Data Set; Dementia; Disease; Doctor of Philosophy; Educational workshop; Elderly; Enrollment; Ensure; Event; Follow-Up Studies; Genitourinary system; Goals; Health; Health behavior; Heart failure; Hormones; Human Resources; Impaired cognition; Impairment; Incentives; Incidence; Infrastructure; Laboratories; Language; Lead; Leadership; Life Experience; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Manuscripts; Measures; Menopause; Monitor; Musculoskeletal; Participant; Physical Function; Physiological; Play; Process; Protocols documentation; Public Health Schools; Quality Control; Quality of life; Reading; Research; Research Personnel; Resources; Risk Factors; Role; Services; Sex Functioning; Sexual Health; Site; Sleep; Sleep disturbances; Specimen; Structure; Study of Women' s Health Across the Nation; Symptoms; Technology; Testing; Training; Universities; Vagina; Vascular Dementia; Vasomotor; Visit; Visuospatial; Well in self; Woman; Women' s Health; Work; actigraphy; age related; bone; cardiometabolism; cardiovascular health; clinical research site; cognitive function; cognitive performance; cohort; critical period; data centers; data management; dementia risk; design; disability; epidemiologic data; experience; follow-up; human old age (65+); improved; instrumental activity of daily living; middle age; mild cognitive impairment; modifiable risk; multi-racial; participant retention; pre-clinical; preservation; psychosocial; racial and ethnic; retention rate; sedentary lifestyle; socioeconomics; success

SWAN-Aging is designed to determine the extent to which midlife health and characteristics of the menopause transition (MT) affect successful aging in women, including the rate of cognitive decline and the risk of dementia and disability. This application proposes to build upon the rich resources of the Study of Women’s Health Across the Nation (SWAN), a longitudinal cohort study initiated in 1994 to characterize the physiological and psychosocial changes that occur during the MT. In SWAN-Aging, we will extend follow-up of the SWAN cohort into early old age (66-75 years) and expand data collection to include additional domains of cognition to detect cognitive impairment (executive and visual-spatial function, language fluency) and the functional impact of cognitive deficits (cognitively demanding instrumental activities of daily living), cardiac health, and sedentary behavior. It is one of a few studies that can quantify the rate of decline in cognitive performance during midlife and early old age and determine the contribution of modifiable risk factors to the incidence of mild cognitive impairment. SWAN-Aging includes three integrated Projects: Project 1 will evaluate the impact of MT characteristics and midlife health indicators on preservation of cognitive function (avoiding cognitive decline and onset of mild cognitive impairment), sleep, genitourinary and sexual function, and quality of life in early old age; Project 2 will test how the MT relates to cardiac health and cardiovascular disease (CVD) events in women in early old age and test how cardiac health relates to early markers of physical impairment, Alzheimer’s disease, and vascular dementia at a critical period in the lifespan; and Project 3 will examine the role of MT and midlife characteristics on musculoskeletal health and physical functioning. The specific aims of Data Collection and Data Management Core (Core 3) are to: 1) Maintain excellent retention of study participants at all clinical sites; 2) Finalize the participant visit protocol and ensure the collection of high quality data from the clinical sites and reading centers; 3) Implement effective quality control measures and provide analytic datasets to study investigators; and 4) Archive and share the SWAN-Aging data. Core 3 will work with the clinical sites to employ effective strategies to maintain SWAN’s high participant retention rate and develop clear, detailed protocols, on-site personnel trainings and quality control measures to monitor the collection of data and specimens. Core 3 will build on the strengths of the existing SWAN data management structure and incorporate improved technology to improve the efficiency of quality control processes. Core 3 will construct datasets to facilitate a variety of analytic strategies to comprehensively assess the role of MT and midlife factors on cognitive decline, cardiac health and physical functioning and will archive de-identified datasets for public use. Core 3 will play a vital role in conducting the Projects by supporting retention and data collection and ensuring that study data will be high quality and used to identify modifiable factors linked to avoidance of mild cognitive impairment, preservation of functioning, and optimization of quality of life in early old age.

Swan-Aging旨在确定中年健康和更年期过渡(MT)的特征对女性成功老龄化的影响程度，包括认知减退率以及痴呆症和残疾的风险。这项申请建议建立在全国妇女健康研究(SWAN)丰富资源的基础上，这是一项始于1994年的纵向队列研究，旨在描述MT期间发生的生理和心理社会变化。在Swan-Aging中，我们将把对Swan队列的跟踪调查扩展到早年(66-75岁)，并扩大数据收集范围，以包括其他认知领域，以检测认知障碍(执行和视觉空间功能、语言流利性)和认知缺陷的功能影响(日常生活中对认知要求较高的工具性活动)、心脏健康和久坐行为。这是为数不多的几项研究之一，可以量化中年和老年早期认知能力的下降速度，并确定可修改的风险因素对轻度认知障碍发生率的贡献。天鹅老龄化包括三个综合项目：项目1将评估MT特征和中年健康指标对认知功能(避免认知衰退和轻度认知障碍的发生)、睡眠、生殖和性功能以及老年早期生活质量的影响；项目2将测试MT与老年早期心脏健康和心血管疾病(CVD)事件的关系，并测试心脏健康与生命关键时期身体损害、阿尔茨海默病和血管性痴呆的早期标志物之间的关系；项目3将探讨MT和中年特征对肌肉骨骼健康和身体功能的作用。数据收集和数据管理核心(核心3)的具体目标是：1)在所有临床站点保持对研究参与者的良好保留；2)最终确定参与者访问协议，并确保从临床站点和阅读中心收集高质量的数据；3)实施有效的质量控制措施并向研究人员提供分析数据集；以及4)归档和共享天鹅老化数据。CORE 3将与临床站点合作，采用有效的策略来保持SWAN的高参与者保留率，并制定明确、详细的方案、现场人员培训和质量控制措施，以监控数据和样本的收集。核心3将建立在现有SWAN数据管理结构的优势之上，并纳入改进的技术，以提高质量控制过程的效率。核心3将构建数据集，以促进各种分析战略，以全面评估MT和中年因素对认知衰退、心脏健康和身体功能的作用，并将未识别的数据集存档供公众使用。核心3将通过支持保留和数据收集，确保研究数据的高质量，并用于确定与避免轻度认知障碍、保持功能和优化老年早期生活质量有关的可修改因素，在实施这些项目方面发挥至关重要的作用。