Core 1: Administrative Core

行政核心的目标将是协调科学、业务和财务 整个计划项目的运作。克雷格·埃尔梅茨博士将领导行政核心和 将由个别项目的领导和核心主任提供协助。《内幕》 和外部咨询委员会将就以下事项向行政核心提供额外咨询意见 每个项目和科学核心的科学方向。行政核心意志 提供必要的领导、监督、指导和行政支持服务 对于及时和合乎道德地进行与本计划项目相关的研究是必要的。在……里面 此外，行政核心将缩短项目和核心领导等的时间 人员需要花费在行政细节上，并让他们专注于科学 该计划的目标。核心还将促进两国之间的互动和沟通 计划项目的组成部分。管理核心将通过 以下职责：1.规划、协调和实施本部门的行政活动 项目和核心的财务管理，并对项目和核心保持健全的财政管理。2.至 通过确保高质量和充分利用 提供的服务，并评估所有项目和核心的资源分配情况。3.推广 项目和核心之间的富有成效的互动，并促进将 加强项目和核心科学家之间的思想交流。4.协调评估 由内部和外部咨询委员会提供。5.为了与UAB的官员进行接触， 国家癌症研究所、威斯康星大学分包公司和其他监管机构 以确保机构和NIH的合规性。协调世界银行的定期会议 数据安全监测委员会，并向IRB、NCI和其他缔约方提供报告 这些报告应该传达给谁。行政核心将定期提供 向NCI报告用于临床生物标记物的试剂的有效性和毒性 审判。6.协调核心的生物统计和生物信息学活动，以确保 调查人员可以随时获得统计咨询和支持。

The goal of the Administrative Core will be to coordinate the scientific, operational, and financial operations of the entire Program Project. Dr. Craig Elmets will lead the Administrative Core and will be assisted by the leaders of the individual projects and by the core directors. The Internal and External Advisory Committees will offer additional advice to the Administrative Core on the scientific direction of each of the Projects and the Scientific Cores. The Administrative Core will provide the necessary leadership, oversight, direction, and administrative support services necessary for the timely and ethical conduction of research related to this Program Project. In addition, the Administrative Core will reduce the time Project and Core leaders and other personnel need to spend on administrative details, and allow them to concentrate on the scientific goals of the program. The Core also will facilitate interaction and communication between components of the Program Project. The Administrative Core will accomplish this with the following responsibilities: 1. To plan, coordinate and implement the administrative activities of the Projects and Cores, and to maintain sound fiscal management of the Projects and Cores. 2. To provide oversight to the core facilities by assuring high quality and adequate utilization of the services provided, and to evaluate resource allocation to all projects and cores. 3. To promote productive interactions between the Projects and Cores and to foster communication that will enhance the exchange of ideas between Project and Core scientists. 4. To coordinate evaluation by the Internal and External Advisory Committees. 5. To interface with officials at UAB, the National Cancer Institute, the University of Wisconsin subcontract and other regulatory agencies to ensure that there is Institutional and NIH Compliance. To coordinate regular meetings of the Data Safety Monitoring Board and provide their reports to the IRB, the NCI and other parties to whom these reports should be communicated. The Administrative Core will provide regular reports to the NCI on the efficacy and toxicity of the reagents employed in the clinical biomarker trial. 6. To coordinate biostatistical and bioinformatics activities of the core to ensure that investigators have ready access to statistical consultation and support.