Survey and Biospecimen Shared Resource

CORE 011-调查和生物质学家共享资源 项目摘要/摘要 调查和生物科学共享资源(SBSR)的使命是提供高质量的调查和 支持范德比尔特-英格拉姆癌症中心(VICC)研究社区的实验室服务，包括我们的 田纳西州立大学梅哈里医学院和其他NCI癌症中心的VICC成员和合作伙伴 中锋。这一使命通过两个截然不同但相辅相成的职能来完成：调查研究服务和 实验室服务。调查服务包括研究设计或实施的咨询、调查 规划、参与者登记、计算机辅助电话面试、病历审查和 研究邮件。实验室服务包括研究设计咨询、生物样品收集、 加工、储存和检索、DNA/RNA提取、基因分型和生物标记物分析。SBSR还 管理多个研究的生物信息库，包括来自三个大型前瞻性队列研究和几个 大型病例对照研究。SBSR的科学联合主任指导了涉及数据和 从美国和国外的20多万名研究参与者中收集生物样本。因此， SBSR为VICC成员提供了在大规模人口中获得重要专业知识和能力的途径- 以研究为基础；避免与雇佣和培训员工进行数据收集和样本相关的启动成本 加工；共享经验丰富的研究人员以降低研究成本；实施严格的质量控制 协议；并支持高质量的样本和数据收集和处理。主要的科学 SBSR的成绩体现在服务利用率和出版物上。SBSR支持多个 招募参与者、收集调查数据和/或生物样品或进行生物学研究的研究 对采集的样本进行化验。26个VICC成员受益于资源的服务，以 提高研究设计和研究质量。拥有同行评审支持的VICC成员占91%， 实验室服务和调查服务分别占总服务使用量的98%。此共享资源 自2015年以来，支持发表了200多篇与癌症有关的手稿，包括在期刊上发表 如《美国医学会杂志》、《自然》、《自然遗传学》、《JNCI》和《癌症研究》。通过实施和共享 在最佳实践中，SBSR工作人员向用户展示了严格执行方法的有效性 以人口为基础的研究，使个人研究人员、学生、研究员和工作人员能够更好地 将这些实践纳入他们的研究计划。因此，SBSR服务对研究至关重要 由VICC成员在多个VICC研究项目中进行。

CORE 011 – SURVEY AND BIOSPECIMEN SHARED RESOUCE PROJECT SUMMARY/ABSTRACT The mission of the Survey and Biospecimen Shared Resource (SBSR) is to provide high-quality survey and laboratory services to support the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI Cancer Centers. This mission is fulfilled through two distinct but complementary functions: survey research services and laboratory services. The survey services include consultation for study design or implementation, survey programming, participant enrollment, computer-assisted telephone interviewing, medical record review and study mailings. The laboratory services include consultation for study design, biospecimen collection, processing, storage and retrieval, DNA/RNA extraction, genotyping, and biomarker assays. The SBSR also manages biorepositories for multiple studies including from three large prospective cohort studies and several large case-control studies. The scientific co-Directors of the SBSR have directed studies involving data and biologic sample collection from more than 200,000 study participants in the United States and abroad. Thus, the SBSR provides VICC members with access to significant expertise and capabilities in large-scale population- based research; avoids the start-up costs associated with hiring and training staff for data collection and sample processing; shares experienced research staff to reduce study costs; implements rigorous quality control protocols; and enables high quality specimen and data collection and processing. The major scientific achievement of the SBSR is reflected in the service utilization and publications. The SBSR supports multiple studies that are recruiting participants, collecting survey data and/or biospecimens, or performing biological assays on collected samples. Twenty-six VICC members have benefited from the services of the resource to improve study design and research quality. VICC members with peer-reviewed support account for 91% and 98% of total service usage for the laboratory services and survey services, respectively. This shared resource has supported the publication of over 200 cancer-related manuscripts published since 2015 including in journals such as JAMA, Nature, Nature Genetics, JNCI and Cancer Research. Through the implementation and sharing of best practices, the SBSR staff demonstrates to users the effectiveness of a rigorous approach to the conduct of population-based research, which enables individual investigators, students, fellows and staff to better incorporate these practices into their research programs. Thus, the SBSR services are critical for the research conducted by VICC members across multiple VICC research programs.