BLRD Research Career Scientist Award Application

申请者是一名基础科学家博士，他开展了一项研究计划，旨在了解 自主神经、新陈代谢和心血管功能受到调节。我特别关注的是 识别控制自主神经的细胞和分子过程和回路 神经系统活动、能量动态平衡和血压由大脑控制。在美国的研究 实验室还致力于揭示这些通路和神经元回路是如何 在肥胖和高血压等疾病条件下调节失调，这些疾病是导致 退伍军人中的发病率和死亡率。详细了解以下项目涉及的流程 健康和疾病中的代谢和心血管调节是必要的，以开发新的 治疗复杂疾病，如肥胖症和相关疾病。我们计划在我们的 之前的工作是扩展我们的研究，以确定新的分子和神经元过程 代谢和心血管调节及其在肥胖中的病理生理作用。我们将重点关注 了解调节自主神经、代谢和心血管控制的机制 MTORC1信令。我们还将研究涉及自主神经、新陈代谢和 一种叫做BBSome的蛋白质复合体对心血管的调节。对这一问题的新见解 MTORC1和BBSome的生理学和病理生理学作用将为 针对这些治疗肥胖症和高血压的分子机制。我也会 通过指导和引导年轻人继续培养下一代生物医学研究人员 科学家，包括基础和临床，以最大限度地发挥他们作为生物医学研究人员的职业潜力。这 对于确保医学进步的光明未来至关重要，这些进步可以改善人们的健康和生活 退伍军人。此外，我将继续致力于为退伍军人事务部、爱荷华州附属大学和 国内和国际科学界通过参与教学、委员会服务、 以及研究倡议和活动的组织。

The applicant is a PhD basic scientist who runs a research program aimed at understanding how the autonomic, metabolism and cardiovascular functions are regulated. I am especially focused on identifying the cellular and molecular processes and circuits that underlie the control of the autonomic nervous system activity, energy homeostasis and blood pressure by the brain. Studies in the laboratory are also directed towards uncovering how these pathways and neuronal circuits are dysregulated in disease conditions such as obesity and hypertension, which are major causes of morbidity and mortality in the VA population. Detailed understanding of the processes involved in metabolic and cardiovascular regulation in health and disease is necessary to develop new treatments for complex disorders such obesity and associated diseases. We plan to build on our previous work to extend our studies to identify new molecular and neuronal processes underlying metabolic and cardiovascular regulation and their pathophysiological role in obesity. We will focus on understanding the mechanisms mediating autonomic, metabolic and cardiovascular control by mTORC1 signaling. We will also investigate the mechanisms involved in autonomic, metabolic and cardiovascular regulation by a protein complex called the BBSome. New insights into the physiological and pathophysiological role of mTORC1 and the BBSome will inform the feasibility of targeting these molecular mechanisms for the treatment of obesity and hypertension. I will also continue training the next generation of biomedical researchers by mentoring and guiding young scientists, both basic and clinical, to maximize their career potential as biomedical investigators. This is crucial to ensure a bright future for medical advances that can improve the health and lives of the Veterans. In addition, I will continue my commitment to serve the VA, affiliated University of Iowa, and the national and international scientific community by participation in teaching, committee service, and organization of research initiatives and events.