BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

项目总结--总体 这项提议的目标是一个协调、协同和综合的Cobre研究计划，称为 “生物系统网络和翻译研究--炎症洞察(BioSNTR-II)”，南方 达科他州立大学(SDSU)，布鲁金斯，SD。我们的研究目标是通过以下方式改善人类健康 通过以下途径促进对炎症分子、细胞和组织水平机制的理解 多学科方法。最重要的假设是，细胞内的调节事件由 在炎症过程中通过巨噬细胞、间质和淋巴轴的细胞间通讯 回应及其解决办法。在资深教师的指导下，初级研究项目负责人定义了这三个 BioSNTR-II在以下领域的研究项目：巨噬细胞生物学在炎症中的作用或原发 纤毛在炎症中调节淋巴管生成及对肿瘤坏死因子信号和细胞的调节作用 死亡之路。这些项目将由(1)转录组中的两个尖端研究核心提供支持 测序、分析和模型开发(转录组和网络分析核心)和(2)CRISPR- 基于基因编辑和集成显微镜和基因评估(CRISPR-IMAGE)。此外，一个 行政核心建议支持财政和人事管理、执行、监督 以及对研究项目和岩心的评估。这些组件的协同和集成 经过精心规划，以最大限度地发挥影响，同时支持培训、专业发展和 一批聪明、有前途的基础研究人员的职业潜力。该中心将通过以下方式取得成功 以下目标：(1)发展和管理SDSU蓬勃发展的炎症研究环境，(2) 建立新的研究中心，以扩大和加强SDSU的生物医学研究，以及(3)指导中心 绩效和可持续性与评估和咨询委员会的意见。

PROJECT SUMMARY – OVERALL The goal of this proposal is a coordinated, synergized, and integrated COBRE research program, called the “BioSystems Networks and Translational Research – Insights into Inflammation (BioSNTR-II),” at South Dakota State University (SDSU), Brookings, SD. Our research objective is to improve human health by advancing the understanding of molecular, cellular and tissue-level mechanisms of inflammation research via multi-disciplinary approaches. The overarching hypothesis is that intracellular regulatory events are governed by cell-cell communication across the macrophage, stromal and lymphatic axes during the inflammatory response and its resolution. Junior research project leaders, mentored by senior faculty, define the three research projects of BioSNTR-II in the areas of: macrophage cell biology in inflammation, the role or primary cilia in regulating lymphangiogenesis in inflammation and regulation of tumor necrosis factor signaling and cell death pathways. These projects will be supported by two cutting-edge research cores in (1) transcriptome sequencing, analysis and model development (Transcriptome and Network Analyses Core) and (2) CRISPR- based gene editing and Integrated Microscopy and Gene Evaluation (CRISPR-IMAGE). In addition, an Administrative Core is proposed to support the fiscal and personnel management, implementation, oversight and evaluation of both the research projects and the cores. The synergy and integration of these components has been carefully planned to maximize impact while supporting training, professional development, and the career potential of a cadre of bright, promising basic researchers. The Center will achieve success through the following aims: (1) Develop and manage a thriving environment for inflammation research at SDSU, (2) Establish new Research Cores to expand and enhance biomedical research at SDSU, and (3) Guide center performance and sustainability with assessment and advisory board input.