Do experiences of early adversity differentially contribute to dynamic fluctuations in dysregulated drinking through their effects on behavioral and emotional dysregulation?

摘要 多达三分之一的年轻人报告每月饮酒行为失调， 每年有1，500多名年轻人死于这一疾病。因此，了解致病因素至关重要， 导致酒精使用失调。大多数年轻人都经历过童年 逆境- 物质使用障碍逆境与饮酒失调之间关系的不一致发现 可以通过研究独特的威胁和剥夺的不良经历来澄清。作为潜在的 逆境的后果和饮酒失调的强预测因子，消极的紧迫感和情绪 失调可能是这种关联的潜在机制。因此，进一步探讨日常生活中的 这些因素的动态是有道理的。本研究旨在探讨早期逆境的经历如何 通过对行为和情绪的影响， 失调本研究将使用生态瞬时评估（EMA）设计，以表征 威胁和剥夺的经历如何促进可能导致日常失调的日常过程 喝酒将招募18-22岁的年轻人（N=500）进行物质的强化纵向评估 使用和影响。参与者将提供他们的负面紧迫感，情绪波动，反射性， 情绪调节，以及日常饮酒意图和使用。这项研究的结果可以为预防提供信息 通过识别导致日常饮酒失调的个体差异因素， 作为可能的干预目标。这项研究是对先前研究的创新，因为 目前还没有一项研究将威胁和剥夺与行为和 情绪失调及其与日常饮酒失调的联系。本研究与 国家酒精滥用和酒精中毒研究所（NIAAA）的战略计划， 对了解高血压期间酒精滥用的发展和改进预防工作的影响 风险发育期的青年成年。该项目的资金将为一名 在伦理学，研究方法，先进的定量方法和职业生涯新兴的博士前研究员 发展总的来说，这个项目将阐明早期逆境有助于行为的过程， 以及这些过程与饮酒失调的关系。

ABSTRACT Up to one-third of young adults report dysregulated drinking behavior each month and alcohol misuse by young adults results in over 1,500 deaths per year. Thus, it is crucial to understand etiologic factors that contribute to the development of dysregulated alcohol use. Most young adults have experienced childhood adversity—and experiences of childhood adversity may account for nearly 1/3 of adolescent and young adult substance use disorders. Inconsistent findings for the relation between adversity and dysregulated drinking may be clarified by examining unique adverse experiences of threat and deprivation. As both potential consequences of adversity and strong predictors of dysregulated drinking, negative urgency and emotion dysregulation may be potential mechanisms for this association. Thus, further exploration into the daily dynamics of these factors is warranted. This study proposes to investigate how experiences of early adversity contribute to dynamic fluctuations in dysregulated drinking through their effects on behavioral and emotional dysregulation. The study will use an ecological momentary assessment (EMA) design in order to characterize how experiences of threat and deprivation contribute to daily processes that may lead to daily dysregulated drinking. Young adults ages 18-22 (N=500) will be recruited for intensive longitudinal assessment of substance use and affect. Participants will provide daily reports of their negative urgency, emotional volatility, reflexive emotion regulation, and daily alcohol intentions and use. Findings from this study could inform prevention efforts by identifying individual difference factors that contribute to dysregulated drinking at a daily level, as well as possible targets for intervention. The proposed study represents innovation over prior research because there has not yet been a study that synthesizes threat and deprivation with fluctuations in behavioral and emotion dysregulation and their links to dysregulated drinking at a daily level. This study is aligned with the strategic plan of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), as it has possible implications for understanding the development and improving prevention of alcohol misuse during the high- risk developmental period of young adulthood. The funding of this project will provide substantial training to an emerging predoctoral researcher in ethics, research methodology, advanced quantitative methods, and career development. Overall, this project will illuminate processes by which early adversity contributes to behavioral and emotional dysregulation, and how these processes relate to dysregulated drinking.