Cancer Center Support Grant

项目摘要/摘要 爱荷华大学霍尔顿综合癌症中心(HCCC)是唯一指定的NCI 爱荷华州的癌症中心，这是一个高度农村的州，作为HCCC的集水区。最近的 综合性癌症中心距离酒店约200英里。HCCC利用其高度的 协作文化，以推进与癌症研究特别相关的跨学科协作研究 爱荷华州的人民。这包括基础癌症研究，一个强大的翻译多研究者组合 资助金包括两项卓越研究专项计划(SPORT)P50资助金、一项新的NCI P01和一项 不断增长的早期临床试验组合，包括基于基础科学的研究 Hccc。HCCC的行政职能是一个基质癌症中心，拥有7个中心成员中的170个 伊利诺伊大学。跨学科科学进步的例子包括对DNA修复的基础研究， 基于HCCC在以下领域的实验室进展进行的多项有希望的早期临床试验 Toll样受体9(TLR9)激动剂和抗坏血酸的药理剂量，治疗方面的创新研究， 以及广泛的淋巴瘤分子流行病学研究，这些研究改变了临床实践。成员们 每年有2340万美元直接用于与癌症相关的、同行评审的外部研究支持。的 这笔1100万美元来自NCI。在上一个供资周期中，HCCC成员发表了1102份同行-- 回顾了与癌症相关的出版物，其中76%涉及机构内、机构间或多机构间的合作。这个 HCCC被组织为四个研究计划。癌症基因与途径(CGP)是基础科学 HCCC的计划。实验治疗学(ET)和自由基代谢与成像(FRMI)是 翻译计划与癌症流行病学和人口科学(CEPS)是一门人口科学 程序。要求为行政管理、评估和规划、临床方案制定和 监测、方案审查和监测以及包括中央生物统计在内的9个共享资源 显微镜、流式细胞术、基因组学、高通量筛选、生物样品采购和分子 流行病学，人口研究，辐射自由基研究和病毒媒介。HCCC有一个 强大的社区外联和参与努力侧重于爱荷华州独特的差异，如乡村、 肥胖症、HPV疫苗接种，促进了HCCC和爱荷华州人民之间的双向互动。 它利用爱荷华州癌症联盟(ICC)的资源和研究基础设施，扩展到 社区。它也有一个全面的职业提升(CE)计划。总而言之，HCCC 提供协作环境、基础设施和资源，以加强跨学科的各个方面 癌症研究在爱荷华州立大学进行。HCCC正在申请癌症中心支持赠款(CCSG)资金 并更新其作为NCI指定的综合癌症中心的地位。

PROJECT SUMMARY/ABSTRACT Holden Comprehensive Cancer Center (HCCC) at the University of Iowa (UI) is the only NCI designated cancer center in the state of Iowa, a highly rural state that serves as the HCCC catchment area. The nearest Comprehensive Cancer Centers are approximately 200 miles away. The HCCC leverages its highly collaborative culture to advance transdisciplinary, collaborative cancer research that is particularly relevant to the people of Iowa. This includes basic cancer research, a strong portfolio of translational multi-investigator grants including two Specialized Program of Research Excellence (SPORE) P50 grants, a new NCI P01 and a growing portfolio of early phase clinical trials including studies based on basic science emerging from the HCCC. The HCCC functions administratively as a matrix Cancer Center with 170 Center members from seven UI colleges. Examples of transdisciplinary scientific advances include fundamental research into DNA repair, multiple promising early phase clinical trials based on laboratory advances made at the HCCC in the areas of toll-like receptor 9 (TLR9) agonists and pharmacologic doses of ascorbate, innovative studies in theranostics, and extensive molecular epidemiologic studies in lymphoma that have changed clinical practice. The members of the HCCC have $23.4 million in direct annual cancer-related, peer-reviewed, external research support. Of this, $11.0 million comes from the NCI. In the last funding cycle, HCCC members published 1,102 peer- reviewed cancer-relevant publications, with 76% involving intra-, inter-, or multi-institutional collaborations. The HCCC is organized into four research programs. Cancer Genes and Pathways (CGP) is the basic science program of the HCCC. Experimental Therapeutics (ET) and Free Radical Metabolism and Imaging (FRMI) are translational programs and Cancer Epidemiology and Population Science (CEPS) is a population science program. Support is requested for administration, evaluation and planning, clinical protocol development and monitoring, protocol review and monitoring and nine shared resources including Biostatistics, Central Microscopy, Flow Cytometry, Genomics, High Throughput Screening, Biospecimen Procurement & Molecular Epidemiology, Population Research, Radiation Free Radical Research and Viral Vector. The HCCC has a robust Community Outreach and Engagement effort focused on unique disparities in Iowa, such as rurality, obesity, HPV vaccination, that facilitates bidirectional interactions between the HCCC and the people of Iowa. It leverages the resources of the Iowa Cancer Consortium (ICC) and research infrastructure that extends into the community. It also has a comprehensive Career Enhancement (CE) Program. In summary, the HCCC provides a collaborative environment, infrastructure and resources to strengthen all aspects of interdisciplinary cancer research taking place at UI. The HCCC is requesting Cancer Center Support Grant (CCSG) funding and renewal of its status as an NCI designated Comprehensive Cancer Center.