Nutrition, Genetics, and Evolution in the Cavefish Model of Autism-like Disorders

这项研究提案的首要目标是通过系统地研究肠道微生物区系如何通过营养改变大脑功能，特别是通过改变大脑区域内和大脑区域之间的活动来确定新的治疗方法。这项研究计划的短期目标是开发工具，在硬骨模型中剖析导致自闭症谱系障碍(ASD)样症状的机制，该模型显示出与自闭症患者相似的肠道微生物组成和核心ASD样行为。

The overarching goal of this research proposal is to identify new therapies by systemically investigating how the gut microbiota through nutrition alters brain functions, particularly by modifying activities within and between brain regions. The short-term goals of this research program are to develop tools to dissect the mechanisms that drive autism spectrum disorder (ASD)-like symptoms in a teleost model, which exhibits a similar composition of the gut microorganism to the ones of autism patients and core ASD-like behaviors.