2023 Physical Virology GRC and GRS

项目摘要 病毒感染涉及从原子尺度的离子转运调节到大分子自身 组装和膜萌发，到全球流行病学。物理病毒学将这些过程作为一种 基本物理定律和新兴生物功能相交的范例。两年一度的GRC 是与物理病毒学相关的不同学科的研究人员参加的唯一国际会议，以及 其独特之处在于它同时关注病毒学的基础和应用方面。的科学目标 这一GRC将(1)揭示支配病毒生命周期的生物物理原理，(2)利用这一知识 推进疫苗、抗病毒药物和基于病毒的生物材料工程的发展，以及(3)拓宽 物理病毒学，以利用细胞生物学和蛋白质设计的最新进展。新冠肺炎大流行 强调这些跨学科方法的必要性，以了解病毒生物学，预测其全球传播 并产生影响，并开发新的治疗方法。2023年物理病毒学GRC将于1月22日至27日在伊利诺伊州举行 1月21-22日在意大利Ciocco举行的戈登研究研讨会(GRS)。我们的会议目标 符合NIAID的使命，支持对传染性疾病病原体的基础和应用研究 NIBIB通过加快生物医学技术的发展来改善健康。 物理病毒学GRC/GRS有三个独立但协同的目标。目标1将促进和 拓宽物理病毒学的跨学科研究。我们有29位特邀演讲者(27位已确认)和9位 物理病毒学前沿的讨论领袖(均已确认)。为了促进跨学科合作， 会议包括来自不同学科的演讲者，重点关注病毒学的共同方面。这次会议 将通过包括以下方面的最新进展来扩展物理病毒学：(1)了解病毒-宿主相互作用(例如，病毒- 宿主蛋白相互作用网络和病毒和宿主免疫系统的共同进化)，(2)病毒- 像其他系统中的笼子一样，以及(3)新冠肺炎上的新兴知识。该计划促进了合作 以及通过非正式讨论时间和4个海报会议建立联系。目标2将增加多样性、公平性、 和物理病毒学社区的包容性(DEI)。在我们的特邀演讲者和讨论领袖中，53% 女性，10%是URM，34%是职业早期研究人员。我们将在选择时放大多样性 简短的谈话。在Power Hour中，参与者将讨论如何解决代表人数不足的群体面临的问题 在科学上。AIM 3将为早期职业研究人员提供培训和职业发展。海报演示文稿 将接受所有学生和博士后的录取，他们将优先选择以下短篇演讲 摘要。GRS是由一名研究生和博士后为这一目标群体组织的。(待定) GRS的主讲人是NIAID疫苗研究中心前副主任Barney Graham博士。

Project Summary Viral infections involve processes from atomic-scale regulation of ionic transport, to macromolecular self- assembly and membrane budding, to global epidemiology. Physical Virology studies these processes as a paradigm for the intersection of fundamental physical laws and emergent biological function. This biennial GRC is the only international meeting for researchers from the diverse disciplines relevant to Physical Virology, and is unique for its simultaneous focus on fundamental and applied aspects of virology. The scientific objectives of this GRC are to (1) uncover the biophysical principles that govern viral lifecycles, (2) use this knowledge to advance development of vaccines, antiviral drugs, and engineering virus-based biomaterials, and (3) broaden physical virology to leverage recent advances in cell biology and protein design. The COVID-19 pandemic highlights the need for these cross-disciplinary approaches to understand viral biology, predict their global spread and impact, and develop new treatments. The 2023 Physical Virology GRC will be held January 22-27 in Il Ciocco, Italy with the accompanying Gordon Research Seminar (GRS) on January 21-22. Our conference goals are in-line with the missions of NIAID to support basic and applied research on causative agents of infectious diseases, and NIBIB to improve health by accelerating development of biomedical technologies. The Physical Virology GRC/GRS have three independent but synergistic Aims. Aim 1 will promote and broaden interdisciplinary research in Physical Virology. We have 29 invited speakers (27 confirmed) and nine discussion leaders (all confirmed) at the frontiers of physical virology. To foster cross-disciplinary collaboration, sessions include speakers from different disciplines focusing on common aspects of virology. The conference will expand physical virology by including recent advances in (1) understanding virus-host interactions (e.g. virus- host protein interaction networks and co-evolution of viruses and host immune systems), (2) assembly of virus- like cages in other systems, and (3) emerging knowledge on COVID-19. The program promotes collaboration and networking through informal discussion times and 4 poster sessions. Aim 2 will increase the diversity, equity, and inclusivity (DEI) of the Physical Virology community. Of our invited speakers and discussion leaders, 53% are women, 10% are URMs, and 34% are early-career researchers. We will amplify diversity when selecting short talks. At a Power Hour, participants will discuss how to address issues faced by underrepresented groups in science. Aim 3 will provide training and career development for early career researchers. Poster presentations will be accepted from all students and postdocs, and they will be given priority for selection of short talks from abstracts. The GRS is organized by a graduate student and postdoc for this target group. The (to be confirmed) GRS keynote speaker is Dr. Barney Graham, former Deputy Director of the Vaccine Research Center at NIAID.