An experimental study of the effects of alcohol intake on subsequent binge eating among adults with clinically-significant binge eating.

饮酒对成人糖尿病暴饮暴食影响的实验研究 临床意义上的暴饮暴食 暴饮暴食的一个潜在维持因素(即对进食失去控制的主观体验) 文献中提到的是饮酒。饮酒，即使是适度的饮酒，也可能增加患上癌症的可能性 随后的暴食发作是由于它对刺激食欲和增加去抑制的影响。而当 跨部门的回溯性研究支持饮酒越多的人也越多 经常暴饮暴食，到目前为止还没有研究通过实验测试是否摄入适量的 酒精会增加随后暴饮暴食的风险。目前的治疗建议是关于 暴饮暴食的人的酒精使用不会给出是否应该改变酒精使用的指导 以及应该为谁提供这些建议。特别是，有理由假设 自我调节能力较低、饮食紊乱症状较严重或较少饮酒/酗酒的个人 在饮酒适量后，饮酒者暴饮暴食的风险更高。考虑到高价 暴饮暴食的人中酒精使用的流行率，决定适度酒精是否 消费增加随后暴饮暴食的风险对于提供量身定做的证据至关重要 关于酒精使用的治疗建议。目前的研究将使用重复的措施 测试酒精对暴饮暴食特征的急性影响的实验设计(即，暴饮暴食的冲动，失去 临床上暴饮暴食的成年人(N=60)中的卡路里摄入量)。参与者将 自我调节的完整生理测量(即心率变异性)和饮食的临床访谈 精神障碍症状和酒精使用模式。在两个平衡研究会议中，参与者将获得 服用中等剂量的酒精(血液酒精浓度为0.08%)或服用非酒精安慰剂 提供了临时试餐。对暴饮暴食、失控以及卡路里的评价 消费量，将在试餐后测量。这项研究的目的是测试：(1)酒精摄入量 会比安慰剂更能预测暴饮暴食的特征，以及(2)自尊心低的人 规律(即低心率变异性)将比那些高自我意识的人支持更多的暴饮暴食特征 监管。第二个目标是测试饮食失调症状和饮酒的缓解效果。 模式。这项研究将大大有助于饮食障碍领域对酒精作用的了解 在维持暴饮暴食方面。此外，目前项目的完成将有助于申请人的 培训(1)酒精研究的实验研究设计，(2)基于实验室的暴饮暴食措施，(3)数据 心率变异性数据的收集和分析，以及(4)专业发展。因此，目前的 项目是申请者实现其职业目标的重要和必要的一步 研究酒精和物质对进食障碍影响的独立学术研究生涯 维护和治疗。

An experimental study of the effects of alcohol intake on subsequent binge eating among adults with clinically significant binge eating One potential maintenance factor of binge eating (i.e., the subjective experience of loss of control over eating) noted in the literature is alcohol consumption. Alcohol use, even at moderate levels, may increase likelihood for subsequent binge eating episodes due to its impact on stimulating appetite and increasing disinhibition. While cross-sectional retrospective research supports that individuals who drink more generally also engage in more frequent binge eating, no study to date has experimentally tested whether consuming a moderate amount of alcohol increases risk for a subsequent binge eating episode. Current treatment recommendations regarding alcohol use in individuals with binge eating do not give guidance on whether alcohol use should be modified and for whom these recommendations should be provided. In particular, there is reason to hypothesize that individuals with low self-regulation, more severe eating disorder symptoms, or less frequent/heavy alcohol consumption are at a higher risk for binge eating after drinking a moderate amount of alcohol. Given the high prevalence of alcohol use among individuals with binge eating, determining whether moderate alcohol consumption increases risk for subsequent binge eating is crucial for providing tailored evidence-based treatment recommendations regarding alcohol use. The current study will use a repeated measures experimental design to test the acute effect of alcohol on binge eating features (i.e., urges to binge eat, loss of control, calorie consumption) among adults with clinically significant binge eating (N = 60). Participants will complete physiological measures of self-regulation (i.e., heart rate variability) and clinical interviews of eating disorder symptoms and alcohol use patterns. In two counterbalanced study sessions, participants will receive a moderate dose of alcohol (blood alcohol concentration of 0.08%) or a non-alcoholic placebo before being provided an ad-libitum test meal. Ratings of urges to binge eat and loss of control, as well as calorie consumption, will be measured following the test meal. The aims of the study are to test if: (1) alcohol intake will be a stronger predictor of binge eating features than the placebo, and (2) individuals with low self- regulation (i.e., low heart rate variability) will endorse more binge eating features than those with high self- regulation. Secondary aims are to test the moderating effects of eating disorder symptoms and alcohol use patterns. This study will contribute significantly to the eating disorder field’s knowledge about the role of alcohol in the maintenance of binge eating. Additionally, completion of the current project will facilitate the applicant’s training in (1) experimental study designs in alcohol research, (2) lab-based measures of binge eating, (3) data collection and analysis of heart rate variability data, and (4) professional development. As such, the current project is an important and necessary step for the applicant to achieve their professional goals of an independent academic research career studying the effect of alcohol and substances on eating disorder maintenance and treatment.