The Effect of Pubertal Hormones on theDevelopment of Neural Oscillatory Dynamics in Youth

项目摘要 本申请描述了作为综合医学博士学位的一部分而获得博士学位的研究计划和学习计划。 内布拉斯加州大学医学中心和博士镇国家研究医院的博士课程。这个 这项研究计划的中心目标是确定脱氢表雄酮(DHEA)、睾酮和雌二醇 调节为选择性注意和工作记忆处理服务的认知系统的发展。 简而言之，青春期过渡期的标志是这些荷尔蒙显著增加，并大量 高级认知功能的发展进展，包括工作记忆、选择性注意、 还有其他人。然而，另一方面，青春期精神疾病的发病率也有所增加， 伴随而来的是疾病患病率的更大性别差异。有人认为，这一现象的出现 青春期的精神疾病可能与荷尔蒙的剧烈变化有关。 发育阶段，但这些荷尔蒙变化对大脑功能和认知的净影响很小 明白了。 这份F30奖学金提案将研究脱氢表雄酮、睾丸素和 雌激素对工作记忆和选择性注意加工的影响 基于脑磁图(MEG)的方法，包括严格的培训和职业发展 计划未来在儿科精神病学和发育认知神经领域的内科科学家- 科学。具体目的是(1)检验青春期激素在预测成绩方面的独特作用 关于选择性注意和工作记忆任务的研究以及(2)识别性类固醇激素与 注意力和工作记忆任务中的水平、神经振荡动力学和行为。实习生是一名 少数民族医学博士/博士生在他的博士学习的第二年，他已经通过两个第一- 在顶级期刊上撰写手稿，参与科学会议并发表论文，以及丰富的历史 学术成就。总而言之，这份F30奖学金的申请将使用MEG，高级来源 重建方法、神经振荡分析和头发样本激素分析来描绘 青春期激素水平、脑动力学和认知发育之间的关系。学习计划 旨在通过由国际知名的MEG专家进行严格培训来支持这项研究计划 和动态脑图，他在指导学员方面有着良好的记录，也是 青春期激素分析和解释，主要目标是发展和扩大研究 和临床技能，以培养出一位装备精良并为下一步做好准备的内科科学家 这是他职业生涯的一个阶段。

Project Summary This application describes the research plan and program of study leading to a PhD as part of a combined MD- PhD Program at the University of Nebraska Medical Center and the Boys Town National Research Hospital. The central goal of this research plan is to identify how dehydroepiandrosterone (DHEA), testosterone, and estradiol modulate the development of cognitive systems serving selective attention and working memory processing. Briefly, the pubertal transition period is marked by significant increases in these hormones and substantial developmental advancements in higher-order cognitive functions, including working memory, selective attention, and others. However, on the other hand, the incidence of psychiatric disease also increases during puberty, and is accompanied by greater sex differences in disease prevalence. It has been suggested that this emergence of psychiatric illness during puberty might be associated with the drastic hormonal changes that mark this developmental stage, but the net impact of these hormonal changes on brain function and cognition is poorly understood. This F30 fellowship proposal will examine the sex and region-specific effects of DHEA, testosterone, and estradiol on working memory and selective attention processing using an advanced dynamic functional mapping approach based on magnetoencephalography (MEG), and includes a rigorous training and career development plan for a future physician-scientist in the areas of pediatric psychiatry and developmental cognitive neuro- science. The specific aims are (1) to examine the unique effects of pubertal hormones in predicting performance on selective attention and working memory tasks and (2) to identify the relationship between sex steroid hormone levels, neural oscillatory dynamics, and behavior during attention and working memory tasks. The trainee is a minority MD/PhD student in his 2nd year of PhD study who has already distinguished himself through two first- authored manuscripts in top journals, participation and presentation in scientific conferences, and a strong history of academic achievement. In sum, this application for an F30 fellowship will use MEG, advanced source reconstruction methods, neural oscillatory analyses, and hair-sampled hormone analysis to delineate the relationship between pubertal hormone levels, brain dynamics, and cognitive development. The program of study is designed to support this research plan through rigorous training by an internationally known expert in MEG and dynamic brain mapping who has a strong record of mentoring trainees, as well as an expert collaborator in pubertal hormone analysis and interpretation, with the primary goals of developing and expanding the research and clinical skills of the applicant to produce a physician-scientist who is well equipped and prepared for the next stage of his career.