Training Program in Translational Science, HIV, and Sexual and Gender Minority Health

项目摘要 在美国，性少数和性别少数(SGM)受到艾滋病毒的沉重负担，包括顺性 少数族裔男性、变性女性和男性，以及出生时被指定为男性的非二元制人。SGM还 经历艾滋病毒以外的巨大健康不平等，包括精神健康问题、药物使用和各种 身体健康结果。少数人应激源(即SGM独有的应激源)与艾滋病毒相关结果有关 和心理健康，由各种生物、心理和社会过程驱动。此外，这些健康问题不会发生在 真空；多种与健康相关的并存问题协同作用，形成驱动艾滋病毒的“合并症” SGM的发病率和艾滋病毒护理结果。为了迅速解决这些问题，我们需要熟练的 翻译科学家，他们可以描绘驱动差异的机械过程，将发现转化为 干预措施，并与社区一起实施方案。建立在西北大学研究所的基础设施上 性和性别少数民族健康和福祉，翻译科学培训计划，艾滋病毒， 性和性别少数民族健康(NU-Thrive)将支持有前途的科学家培养技能 有必要了解这些复杂的关系，减轻影响SGM人群的健康差距， 包括艾滋病毒。NU-Thrive旨在培训翻译学院博士后研究员的研究方法 科学光谱通过一个严格的计划，他们将：1)专业化和获得深度的知识在 2个翻译科学技能领域(即定量方法、定性方法、干预和试验、 实施科学)通过有指导的研究；以及2)在所有四个领域获得知识广度 通过正规的培训课程。NU-Thrive将每年支持3名新的博士后研究员，为期2年 预约。我们预计大多数人将拥有博士学位(行为/社会科学)，少数人将是医学博士 内科医生-科学家。研究员将选出1名主要导师和1名中学导师。主要导师是那些 主要关注艾滋病毒、精神健康和/或SGM健康。二级导师来自一系列 学科和专业知识与NU-Thrive的目标相辅相成，但可能在外部或邻近地区工作 在SGM中对艾滋病毒和精神健康的关注。学员将获得8项核心能力方面的知识和技能：1) 艾滋病毒和SGM健康中的翻译科学；2)艾滋病毒的生物心理社会驱动因素，精神健康，以及相关 合并症；3)发育寿命和环境对艾滋病毒、心理健康和合并症的影响；4) 跨部门身份、艾滋病毒和SGM健康；5)团队科学技能；6)道德和负责任的行为 研究；7)写作、传播和天赋；8)职业和职业发展。Nu-Thrive 培训形式将包括有指导的研究活动、一系列教学研讨会、强化培训 翻译科学方法，结构化写作支持，以及丰富的西北大学提供的其他活动 环境。NU-Thrive将把研究员放在艾滋病毒和SGM健康研究的前沿，目标是 更快地将基础科学发现转化为有效的干预措施，并推动实施。

Project Summary Sexual and gender minorities (SGM) are heavily burdened by HIV in the U.S., including cisgender sexual minority men, transgender women and men, and non-binary people assigned male at birth. SGM also experience vast health inequities outside of HIV, including mental health problems, substance use, and various physical health outcomes. Minority stressors (i.e., those unique to SGM) are linked to HIV-related outcomes and mental health, driven by various biopsychosocial processes. Further, these health issues do not occur in a vacuum; multiple, comorbid health-related issues interact synergistically to form a “syndemic” that drives HIV incidence and HIV care outcomes among SGM. In order to rapidly address these issues, we need skilled translational scientists who can delineate the mechanistic processes driving disparities, translate findings into interventions, and implement programs with communities. Built on the infrastructure of Northwestern's Institute for Sexual and Gender Minority Health and Wellbeing, the TrainingProgram in Translational Science, HIV, andSexual and Gender Minority Health (NU-THRIVE)will support promising scientists in building the skills necessary to understand these complex relationships and mitigate health disparities impacting SGM people, including HIV. NU-THRIVE aims to train postdoctoral fellows in research methods across the Translational Science Spectrum through a rigorous program in which they will: 1) specialize and gain depth of knowledge in 2 Translational Science Skill Domains (i.e., Quantitative Methods, Qualitative Methods, Interventions & Trials, Implementation Science) through mentored research; and 2) gain breadth of knowledge in all 4 domains through a formal training curriculum. NU-THRIVE will support 3 new postdoctoral fellows per year, on 2-year appointments. We expect a majority will have a PhD (behavioral/social science) and a minority will be MD physician-scientists. Fellows will select 1 Primary and 1 Secondary Mentor. Primary Mentors are faculty who focus primarily on HIV, mental health, and/or SGM health. Secondary Mentors come from a range of disciplines and have expertise complementary to the aims of NU-THRIVE but may work outside of or adjacent to HIV and mental health among SGM. Fellows will gain knowledge and skills in 8 core competencies: 1) translational science in HIV & SGM health; 2) biopsychosocial drivers of HIV, mental health, & associated comorbidities; 3) developmental lifespan & environmental influences on HIV, mental health, & comorbidities; 4) intersectional identities, HIV, & SGM health; 5) team science skills; 6) ethics & responsible conduct of research; 7) writing, dissemination, & grantsmanship; 8) professional & career development. NU-THRIVE training modalities will include mentored research activities, a didactic seminar series, intensive trainings in translational science methods, structured writing support, and other activities available in the rich Northwestern environment. NU-THRIVE will place fellows at the forefront of HIV and SGM health research, with the goal of more rapidly moving basic science discoveries to efficacious interventions and onward toward implementation.