Effectiveness of Relationship Education for Reducing HIV Incidence in Men Who Have Sex with Men
关系教育对降低男男性行为者艾滋病毒发病率的有效性
基本信息
- 批准号:10379360
- 负责人:
- 金额:$ 192.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAddressAffectAgreementBehaviorBehavioralBlack raceCharacteristicsColorCommunicationCost AnalysisCoupledCouplesEducationEffectivenessEffectiveness of InterventionsElementsEnrollmentEthnic OriginFundingGoalsHIVHIV InfectionsHIV SeronegativityHIV riskHealthHuman immunodeficiency virus testHybridsIncidenceIndividualInfectionInterventionInterviewLatinxMeasuresMethodsOutcomeParticipantPersonal SatisfactionPreventionPrevention programPrevention strategyPreventivePreventive servicePublic HealthRaceRandomized Controlled TrialsResearchResearch MethodologyRiskRisk BehaviorsRuralSafetySamplingSexual PartnersSubgroupSumTestingUnderserved PopulationUnited StatesUnited States National Institutes of Healthacceptability and feasibilitybasecisgenderclinical decision-makingcondomless anal sexcondomsconflict resolutioncostcost effectivecost estimateeHealtheffectiveness evaluationeffectiveness implementation trialeffectiveness testingevidence baseexperiencefollow-upfuture implementationhigh riskimplementation barriersimplementation determinantsimplementation outcomesimplementation strategyimprovedinnovationinterestmale couplesmen of colormen who have sex with menpilot trialpost interventionpre-exposure prophylaxispreferenceprogram costsprogramsrandomized trialrecruitrectalruralitysecondary outcomeskillstransgendertransgender mentreatment armtreatment effecttrial designuptakeyoung men who have sex with men
项目摘要
Men who have sex with men (MSM) are disproportionately impacted by HIV in the United States. Young MSM
(YMSM), particularly YMSM of color, have the highest HIV incidence of any group. Despite the perceived
safety of romantic relationships, main partnerships account for a large proportion of new HIV infections in MSM
(35-68%), and this proportion is much higher amongst YMSM. MSM substantially reduce condom and PrEP
use upon entry into a relationship, despite continued high risk for many couples. However, healthy romantic
relationships provide myriad benefits to individual health and wellbeing. Thus, we created 2GETHER, which
integrates evidence-based relationship education (e.g., communication, conflict resolution) and HIV prevention
(e.g., monogamy/non-monogamy agreements, behavioral/biomedical prevention), to optimize relationship
functioning and reduce HIV risk in male couples. 2GETHER demonstrated evidence of feasibility and
acceptability, as well as preliminary effects on HIV risk behaviors and relationship functioning, in a pilot trial.
We have also adapted 2GETHER for online administration, consisting of 3 online didactic skills modules and 2
videoconference-based skills coaching sessions, and are evaluating its efficacy in a randomized trial. Despite
its promise, we have identified several critical gaps in couple-based HIV prevention: 1) live skills coaching is
burdensome and not cost-effective, 2) many partnered MSM are unable to enroll partners and are thus
excluded, and 3) newer, high risk relationships rarely enroll in trials, so we need to deliver relationship skills to
single MSM before relationship initiation. Our goal is to upgrade 2GETHER into a scalable and tailored
intervention package for both single and partnered MSM, consisting of: 1) a standalone relationship education
and HIV prevention eHealth program (“eRE”) for single and partnered MSM, and 2) two additional dyadic skills
coaching sessions (for MSM participating as dyads only). Aim 1: Evaluate the impact of the tailored 2GETHER
intervention package on HIV incidence in MSM. We will enroll 5,000 HIV-negative MSM to test effectiveness of
the entirety of the 2GETHER tailored intervention package on HIV incidence at 24-months post-intervention
relative to control. We will also explore effects of particular tailored elements: (a) examine differential
effectiveness between single and partnered MSM; (b) among partnered MSM, analyze the additive benefit of
dyadic skills coaching sessions beyond the automated eRE program. Aim 2: Explore differential effects across
treatment arms among subgroups of MSM. We will explore differential effects across treatment arm by age,
race/ethnicity, rurality, and transgender experience. Aim 3: Research the implementation of 2GETHER
nationally to inform scale out and determine cost. Employing a Hybrid Type 1 Effectiveness–Implementation
Trial design, we will use mixed methods to identify facilitators and barriers to implementation. We will measure
key implementation determinants and outcomes through in-depth interviews with national stakeholders to
inform future implementation strategies, and conduct cost analysis to estimate cost of program implementation.
在美国,男男性行为者(MSM)受到艾滋病毒的影响不成比例。年轻的男男同性恋者
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael E Newcomb其他文献
Michael E Newcomb的其他文献
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{{ truncateString('Michael E Newcomb', 18)}}的其他基金
Training Program in Translational Science, HIV, and Sexual and Gender Minority Health
转化科学、艾滋病毒、性和性别少数群体健康培训计划
- 批准号:
10608209 - 财政年份:2022
- 资助金额:
$ 192.17万 - 项目类别:
Effectiveness of Relationship Education for Reducing HIV Incidence in Men Who Have Sex with Men
关系教育对降低男男性行为者艾滋病毒发病率的有效性
- 批准号:
10604353 - 财政年份:2021
- 资助金额:
$ 192.17万 - 项目类别:
A New Approach to Integrating Primary and Secondary HIV Prevention in Young Male Couples
年轻男性夫妇艾滋病毒一级和二级预防一体化的新方法
- 批准号:
9179853 - 财政年份:2016
- 资助金额:
$ 192.17万 - 项目类别:
Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men
基于夫妇的艾滋病毒预防对弱势年轻男性的功效
- 批准号:
9766168 - 财政年份:2016
- 资助金额:
$ 192.17万 - 项目类别:
Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men
基于夫妇的艾滋病毒预防对弱势年轻男性的功效
- 批准号:
9355070 - 财政年份:2016
- 资助金额:
$ 192.17万 - 项目类别:
Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men
基于夫妇的艾滋病毒预防对弱势年轻男性的功效
- 批准号:
9204168 - 财政年份:2016
- 资助金额:
$ 192.17万 - 项目类别:
Investigating change in HIV risk in a self-monitoring diary study
在自我监测日记研究中调查艾滋病毒风险的变化
- 批准号:
8542374 - 财政年份:2013
- 资助金额:
$ 192.17万 - 项目类别:
Investigating change in HIV risk in a self-monitoring diary study
在自我监测日记研究中调查艾滋病毒风险的变化
- 批准号:
8625292 - 财政年份:2013
- 资助金额:
$ 192.17万 - 项目类别:
An investigation of a Situational Model of Risk for MSM
MSM 风险情景模型的调查
- 批准号:
8151082 - 财政年份:2010
- 资助金额:
$ 192.17万 - 项目类别:
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