Cancer Research International Training and Intervention Consortium (CRITIC)

描述（由申请人提供）：拟议的癌症联盟的重点是干预两种最常见的艾滋病相关癌症（卡波西肉瘤相关人类疱疹病毒（KSHV）和坦桑尼亚人乳头瘤病毒（HPV））的两种病原病毒因子的传播和感染。该联合会的目标是加强艾滋病恶性肿瘤研究基础设施的三个关键组成部分-病毒学、流行病学和临床护理-通过将在这些领域具有有据可查的优势的伙伴联系起来。除了获得与艾滋病有关的恶性肿瘤的关键数据外，联合会还将提供各种培训机会，以增加当地的专门知识和转让技术。总的来说，这种伙伴关系最终将导致建立技术和人员基础设施的交流 坦桑尼亚迫切需要进行高质量的生物医学、行为学和预防性生物医学研究。将追求四个具体目标：1）通过长期的分子癌症流行病学培训机会建立联盟的研究能力，长期培训导致流行病学和分子肿瘤病毒学两个博士学位，分子肿瘤病毒学硕士学位和癌症流行病学硕士学位。2)通过在美国的短期技术培训和针对研究人员、临床医生和公共卫生人员的国内研讨会，加强现有的癌症研究能力。3)发展分子病毒学研究实验室和流行病学/生物统计学核心设施，以支持分子癌症流行病学研究项目。4)支持坦桑尼亚研究团队的发展，并通过支持两个假设驱动的研究项目，在两个最流行的艾滋病相关的恶性肿瘤，KS和宫颈癌，提高研究生产力。这项拟议的计划是独特的，具有很高的影响力，因为它建立在一个成功的正在进行的福格蒂计划和NCI培训计划在撒哈拉以南非洲地区，扩展到一个真正的跨学科的研究和培训计划，不同的培训轨道和国内研究项目合作坦桑尼亚和美国研究人员进行假设驱动的研究KS，宫颈癌，及其各自的病因代理。

DESCRIPTION (provided by applicant): The proposed Cancer Consortium focuses on the intervention of transmission and infection by two etiologic viral agents of the two most common AIDS-associated cancers, the Kaposi's sarcoma-associated human herpes virus (KSHV) and Human Papilloma Virus (HPV) in Tanzania. The objective of the Consortium is to enhance the three critical components of AIDS malignancies research infrastructure - virology, epidemiology and clinical care - by linking partners with documented strengths in these areas. In addition to deriving critical data on AIDS-associated malignancies, the Consortium will provide diverse training opportunities to increase local expertise and transfer technology. Overall, the partnership will ultimately lead to exchanges that build the technical and personnel infrastructure necessary to perform the high-quality biomedical, behavioral, and preventative biomedical research desperately needed in Tanzania. Four specific aims will be pursued: 1) Build the consortium's research capacity through long-term molecular cancer epidemiology training opportunities, with long-term training leading to two PhDs, in epidemiology and in molecular tumor virology, MS degrees in molecular tumor virology, and MPH degrees in cancer epidemiology. 2) Strengthen existing cancer research capacity through short term technical training in the US and in-country workshops targeting researchers, clinicians, and public health personnel. 3) Develop a molecular virology research laboratory component and epidemiology/biostatistics core facilities to support molecular cancer epidemiology research projects. 4) Support the development of Tanzanian research teams and increase the research productivity through supporting two hypothesis-driven research projects in the two most prevalent AIDS-associated malignancies, KS and cervical cancer. This proposed program is unique and of high impact because it builds onto a successful ongoing Fogarty program and NCI training program in sub-Saharan Africa, expanding it into a truly cross-disciplinary research and training program with different training tracks and with in-country research projects teaming Tanzanian and U.S. researchers to conduct hypothesis-driven research on KS, cervical cancer, and their respective etiologic agents.