Prevalence of Kaposi's sarcoma-associated herpesvirus and transfusion-transmissible infections in Tanzanian blood donors.
Prevalence of Kaposi's sarcoma-associated herpesvirus and transfusion-transmissible infections in Tanzanian blood donors.
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DOI：
10.1016/j.ijid.2020.04.018
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
West JT
中科院分区：
文献类型：
--
作者：
Lidenge SJ;Tran T;Tso FY;Ngowi JR;Shea DM;Mwaiselage J;Wood C;West JT
卡波西肉瘤相关疱疹病毒(KSHV)是坦桑尼亚最常见的癌症之一卡波西肉瘤(KS)的病原体。我们调查了坦桑尼亚的KSHV流行率和与KSHV感染相关的因素。这是一项对坦桑尼亚达累斯萨拉姆自愿献血者的横断面研究。检测血浆中KSHV、HIV-1、乙肝病毒、丙型肝炎病毒和梅毒螺旋体。分析KSHV血清状态与危险因素的关系。报告了评价KSHV感染危险因素的优势比(OR)和95%可信区间(CI)。所有的测试都是双尾的，P值<；0.05被认为具有统计学意义。总的KSHV血清阳性率为56.9%。湖区和中心区人群感染KSHV的危险性显著增加(OR=6.495%CI=1.6~25.3，P=0.008和OR=5.7，95%CI=1.0~32.5，P=0.048)。KSHV合并HIV-1感染的危险性增加趋势不明显(OR=2.8，95%CI=1.0~8.0，P=0.06)。梅毒螺旋体的血清反应率高得惊人(14.9%)。坦桑尼亚献血者中KSHV感染和梅毒的流行率很高。最常见的输血传播感染与KSHV感染无关。局灶性KSHV感染地区需要进一步调查未被充分认识的危险因素。
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent for Kaposi’s sarcoma (KS), one of the most common cancers in Tanzania. We have investigated KSHV prevalence and factors associated with KSHV infection in Tanzania. This is a cross-sectional study of voluntary blood-donors from Dar es Salaam, Tanzania. Plasma was screened for KSHV, HIV-1, HBV, HCV and T. pallidum (syphilis). Associations between KSHV sero-status and risk factors were analyzed. Odds ratios (OR) and 95% confidence intervals (CI) are reported to evaluate risk factors of KSHV infection. All tests were 2-tailed, and P-values <0.05 were considered statistically significant. The overall KSHV seroprevalence was 56.9%. Significantly increased risk of KSHV infection was detected in persons from the Lake and Central Zones (OR=6.4, 95% CI=1.6–25.3, P=0.008 and OR=5.7, 95% CI=1.0–32.5, P=0.048 respectively). A trend towards increased risk of KSHV infection with HIV-1 co-infection was not significant (OR=2.8, 95% CI=1.0–8.0, P=0.06). Seroreactivity to T. pallidum was surprisingly high (14.9%). The prevalence of KSHV infection and syphilis was high among Tanzanian blood-donors. The most common transfusion-transmissible infections did not associate with KSHV infection. Regions of focal KSHV infection need further investigation for underappreciated risk factors.
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DOI：
10.3390/v6114178
发表时间：
2014-11-04
期刊：
Viruses
影响因子：
--
作者：
Minhas V;Wood C
通讯作者：
Wood C
影响因子：
8.8
作者：
Cook-Mozaffari, P;Newton, R;Beral, V;Burkitt, D P
通讯作者：
Burkitt, D P
影响因子：
--
作者：
Franceschi, S;Geddes, M
通讯作者：
Geddes, M
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
6.4
作者：
de Sanjose, Silvia;Mbisa, Georgina;Whitby, Denise
通讯作者：
Whitby, Denise