You and Me Healthy: Testing Protocol

在美国，已有7900万人感染了SARS-CoV-2，90万人死亡，但仍有病例 死亡对服务不足的人口造成了不成比例的影响。疾病早期的新疗法可能会改变 大流行的进程，但解决及时检测和药物获取方面的差异的战略对于 最大限度地发挥影响力。社区主导的干预措施提供了在服务不足人群中进行检测的机会 在大流行的早期，但需要量身定做，以促进检测和治疗方案以及快速获得 应对当前威胁的治疗。这项提案将评估一个系统和可扩展的社区- 采用测试和治疗方案，提供快速访问自检、“下一步”指导和本地 为服务不足人群提供便利治疗的资源。我们将评估一个社区参与工具包， 您和我的健康工具包，基于我们的专业知识和经验开发，以实施基于社区的 在服务不足的地区测试分发以及测试和治疗对下一阶段新冠肺炎大流行的反应 人口。我们的中心假设是，You&Me Healthy工具包将支持快速设计和 实施社区驱动、科学稳健和有影响力的新冠肺炎测试和 治疗干预。我们将利用成功的伙伴关系和基础设施，通过两个 大型国家RADX-UP资助的SARS-CoV2检测和教育干预(说是！COVID测试， 你和我免费)；对社区参与感兴趣的参与者的积极注册 研究(你我健康注册)；与社区参与专家建立伙伴关系(社区 校园健康伙伴关系)；以及与默塞德150多个当地社区合作伙伴的合作历史 加利福尼亚州皮特县和北卡罗来纳州皮特县，少数民族(西班牙裔/拉丁裔/拉丁裔和黑人)比例高，高度贫困 医疗保险覆盖率低。我们将应用此工具包来开发快速部署测试和治疗 通过我们在两个社区的合作伙伴实施的协议，直接应对SARS-CoV2 在15个月的时间里，感染激增或发生社区确定的高危事件。我们将检验这一假设 通过以下具体目标：1)评估YMH工具包快速创建有效学术的能力- 促进新冠肺炎测试接入的社区研究伙伴关系；2)记录在家测试的结果 使用社区参与的可扩展报告方法；3)评估测试和治疗方案的能力，以及 提供当地资源，以促进及时获得检测、指导、资源联系和治疗。这部作品 将展示通用工具包的价值，以促进快速有效的学术社区 建立伙伴关系，以便在#年服务不足的人群中及时进行检测并获得有效的治疗 对新冠肺炎的响应激增或传播威胁。

In the United States, >79 million people have been infected with SARS-CoV-2 and >900,000 died, but cases and deaths disproportionately affect underserved populations. Novel treatments early in disease may transform the pandemic’s course, but strategies that address disparities in timely testing and drug access are essential to maximize impact. Community driven interventions provided access to testing in underserved populations earlier in the pandemic, but need to be tailored to promote test and treat protocols and rapid access to treatment in response to current threats. This proposal will evaluate a systematic and scalable community- engaged test and treat protocol that provides rapid access to self-testing, “next steps” guidance, and local resources to facilitate treatment in underserved populations. We will evaluate a community engagement toolkit, You & Me Healthy Toolkit, developed based on our expertise and experience, to implement community-based test distribution and test and treat responses to the next phase of the COVID-19 pandemic in underserved populations. Our central hypothesis is that that the You & Me Healthy Toolkit will enable rapid design and implementation of a community driven, scientifically robust, and impactful COVID-19 test and treatment intervention. We will leverage successful partnerships and infrastructure established through two large national RADx-UP funded SARS-CoV2 testing and education interventions (SAY YES! COVID TEST, You & Me COVID-Free); an actively enrolling registry of participants interested in community-engaged research (You & Me Healthy Registry); partnerships with community engagement experts (Community Campus Partnerships for Health); and a history of collaboration with 150+ local community partners in Merced County, CA and Pitt County, NC with high proportion minority (Hispanic/Latino/Latinx and Black), high-poverty and low health insurance coverage. We will apply this toolkit to develop a rapid-deployment test and treat protocol implemented through our partners in two communities, launched in direct response to SARS-CoV2 infection surges or at community-identified high-risk events over a 15 month period. We will test this hypothesis through the following specific aims: 1) Evaluate the YMH toolkit ability to rapidly create effective academic- community research partnerships for promoting COVID-19 test access; 2) Document results of at-home tests using a community-engaged scalable reporting approach; 3) Evaluate ability of a test and treat protocol and local resourcing to facilitate timely access to testing, guidance, resource linkage, and therapeutics. This work will demonstrate the value of a generalizable toolkit to promote rapid and effective academic-community partnerships to enable timely testing and access to effective therapeutics in underserved populations in response to COVID-19 surges or transmission threats.