Core D: Clinical Sciences

项目摘要/摘要-临床科学核心D 锈带CFAR临床科学核心D，由一群经验丰富的综合团队管理 艾滋病毒/艾滋病临床研究人员和工作人员，将作为CFAR用户提出或 进行涉及人类参与者、临床数据或样本的临床或转化性研究。初级阶段 该中心提供的服务包括：(I)快速获取现有临床数据和人员的资料库样本 (Ii)应要求从威尔斯亲王医院获取新鲜生物样本，有感染风险的人， 和未受感染的低风险个人，以及(Iii)CFAR为调查人员提供的集中临床支持 设计、实施、实施和分析在扩展的 铁锈带CFAR。在下一个赠款周期中，我们的能力将通过增加 匹兹堡杰出的临床队列。合并后的核心将包括艾滋病毒预防方面的专业知识，物质 使用和治疗研究。此外，可以获得的标本范围也将大大增加。 通过采购白细胞分离样本、胃肠道组织、脑脊液(CSF)、 宫颈组织、胎盘、脐带血、支气管肺泡灌洗液(BAL)、粪便和生殖器分泌物 翻译研究。Core D与患者社区和附属的艾滋病人保持着牢固的关系 服务组织和机构通过社区咨询委员会定期会议和 正在进行的倡议包括无艾滋病匹兹堡和结束克利夫兰的流行病(在CLE中的ethe)。铁锈带 CFAR核心D领导人将指导CFAR调查人员，并将其与正在进行的队列和研究小组联系起来，例如 匹兹堡艾滋病毒肺部研究队列和CFAR综合临床系统网络以增强 利用这些强大的现有资源。核心D还将与发展核心B密切合作 确保被选为试点和催化奖的项目取得成功。此外，Core D将与 与核心E(病毒致病和持久性)和F(系统生物学和生物统计学)密切合作，以确保 以高效和协调的方式向CFAR用户提供全面的可用资源 时尚。最后，核心D将与乌干达核心C合作，为CFAR用户提供参与者访问权限 来自乌干达CFAR国际站点的数据和样本，以及将CFAR国际调查人员联系起来 到核心D可用的资源。因此，核心D扩大了对现有资源的利用，用户来自 多个机构，并聘请新的和/或青年研究人员在地方，国家， 和国际水平。

PROJECT SUMMARY/ABSTRACT – CLINICAL SCIENCES CORE D The RUSTBELT CFAR Clinical Sciences Core D, managed by an integrated group of highly experienced HIV/AIDS clinical investigators and staff, will serve as the centralized resource for CFAR users proposing or conducting clinical or translational research involving human participants, clinical data, or samples. The primary services provided by the core are (i) rapid access to existing clinical data and repository samples from persons with HIV (PWH), (ii) on-demand acquisition of fresh biologic samples from PWH, persons at risk for infection, and uninfected low risk individuals, and (iii) centralized clinical support provided by the CFAR to investigators for the design, implementation, conduct, and analysis of clinical research studies across the sites in the expanded RUSTBELT CFAR. In this next grant cycle, our capabilities will be dramatically enhanced by the addition of the outstanding Pittsburgh clinical cohorts. The merged Core will include expertise in HIV prevention, substance use, and cure research. Furthermore, the range of specimens that can be obtained will also be dramatically enhanced through the procurement of leukopheresis samples, gastrointestinal tissue, cerebrospinal fluid (CSF), cervical tissue, placenta, cord blood, bronchoalveolar lavage fluid (BAL), stool, and genital secretions for translational research. Core D maintains strong relationships with patient communities and affiliated AIDS service organizations and agencies through regular meetings of the Community Advisory Boards (CABs) and ongoing initiatives including AIDS-free Pittsburgh and End the Epidemic in Cleveland (EtHE in CLE). RUSTBELT CFAR Core D leaders will guide and link CFAR investigators to ongoing cohorts and study groups such as the Pittsburgh HIV Lung Research Cohort and the CFAR Network of Integrated Clinical Systems to enhance utilization of these powerful existing resources. Core D will also work closely with the Developmental Core B to ensure success of the projects selected for pilot and catalytic awards. Additionally, Core D will collaborate closely with Cores E (Viral Pathogenesis & Persistence) and F (Systems Biology & Biostatistics) to ensure that CFAR users are provided with the full spectrum of available resources in an efficient and coordinated fashion. Finally, Core D will collaborate with the Uganda Core C to provide CFAR users access to participant data and samples from the CFAR international site in Uganda, as well as to link international CFAR investigators to resources available from Core D. Thus, Core D broadens utilization of existing resources with users from multiple institutions and engages new and/or young investigators in HIV/AIDS research at the local, national, and international levels.