Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease

项目摘要 本研究拟对“生物工程研究与技术开发”的博士前培养项目进行研究， 心血管健康与疾病”，旨在培养优秀和多样化的博士前 生物工程专业的学生应用定量和综合跨学科的方法，以基本 心肺，血管，血液和睡眠病理生理学的转化研究， 开发心血管疾病诊断、治疗和临床管理的新技术 和心肺疾病。该课程是建立在四个交叉的技术主题， 生物工程培训教师是专家：（a）生物力学和机械生物学;（B）生物材料，细胞和 组织工程;（c）计算和系统生物学;（d）成像和生物光子学。学员将 集中学习其中两个主题的课程。来自生物医学科学的培训教师将 在主要科学领域（包括基础和翻译）担任所需的跨学科共同导师 心肺、血管和血液研究。目标是培养新一代的生物工程师， 成为改善心血管健康的研究和技术开发的创新者。的 领导团队有三个MPI：Andrew McCulloch博士（联系PI），主持指导委员会（SC）， 负责行政、招生和评估。凯伦·克里斯曼医生将主要负责 Geert Schmid-Schönbein博士将监督项目具体活动 包括课程、研讨会、年度务虚会和专题讨论会。培训教师包括 杰出和资金充足的生物工程师，基础生物医学科学家，医生科学家和公共卫生 具有出色的合作研究培训记录的专家。SC已建立有效的 招聘、录取、培训和评估程序，确保有大量和多样化的人才库， 优秀的候选人，100%的保留率和出色的结果。课程将包括必修内容 心血管生理学，心血管系统分子生物学， 以患者为中心的生物工程临床医学，心血管生物工程数据科学， 负责任的研究行为和严谨性和再现性，以及生物工程选修课，从两个 或更多的四个技术主题。凭借我们成功的初级教师职业发展的记录，我们 包括自2017年以来招募七名优秀和多样化的新初级工程学院，其中一名 在心血管内科有一个联合临床任命。他们将共同指导新领域的学员 包括生物光子学、医学成像、精密生物材料、肺动脉高压、心脏瓣膜 疾病和神经血管损伤。所有教师将接受导师培训，并计划进展， 将由两个咨询委员会和受训人员调查对成果进行评估。结果将是科学家 他们使用综合的、技术驱动的方法来推进心血管科学和医疗保健。

Project Summary This proposal for pre-doctoral training on “Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease”, aims to train outstanding and diverse predoctoral bioengineering students in applying quantitative and integrative interdisciplinary approaches to basic and translational research in cardiopulmonary, vascular, blood and sleep pathophysiology and in developing novel technologies for the diagnosis, treatment and clinical management of cardiovascular and cardiopulmonary diseases. The curriculum is built on four intersecting technology themes that the Bioengineering training faculty are expert in: (a) Biomechanics and Mechanobiology; (b) Biomaterials, Cell and Tissue Engineering; (c) Computational and Systems Biology; and (d) Imaging and Biophotonics. Trainees will take coursework with a concentration in two of these themes. Training faculty from the biomedical sciences will serve as required interdisciplinary co-mentors in the major scientific areas including basic and translational cardiopulmonary, vascular and blood research. The goal is to develop a new generation of bioengineers who become innovators in research and technology development for improving cardiovascular health. The leadership team has three MPIs: Dr. Andrew McCulloch (contact PI), chairs the Steering Committee (SC) and is responsible for administration, admissions and evaluation. Dr. Karen Christman will be primarily responsible for translational research training and Dr. Geert Schmid-Schönbein will oversee program-specific activities including curriculum, seminars, and the annual retreat and symposium. The training faculty includes outstanding and well-funded bioengineers, basic biomedical scientists, physician-scientists and public health experts with exceptionally strong records of collaborative research training. The SC has established effective recruitment, admission, training and evaluation procedures that ensure a large and diverse pool of well-qualified candidates, 100% retention, and excellent outcomes. The curriculum will include required program-specific courses in Cardiovascular Physiology, Molecular Biology of the Cardiovascular System, Patient-Centered Clinical Medicine for Bioengineers, Data Science for Cardiovascular Bioengineering, Responsible Conduct of Research and Rigor and Reproducibility, as well as bioengineering electives from two or more of the four technology themes. With our record of successful junior faculty career development, we include seven outstanding and diverse new junior engineering faculty recruited since 2017, including one who has a joint clinical appointment in Cardiovascular Medicine. They will co-mentor trainees in new areas including biophotonics, medical imaging, precision biomaterials, pulmonary arterial hypertension, heart valve disease, and neurovascular injury. All faculty will receive mentorship training, and program progress and outcomes will be assessed by two advisory committees and trainee surveys. The outcome will be scientists who use integrative, technology-driven approaches to advance cardiovascular science and healthcare.