Cardiopulmonary outcomes of dual cigarette and e-cigarette use in animal models of chronic exposure
慢性暴露动物模型中同时使用香烟和电子烟的心肺结果
基本信息
- 批准号:10666054
- 负责人:
- 金额:$ 75.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-18 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcetylcholineAdultAerosolsAffectAirAirway ResistanceAmericanAnimal ModelAnimalsAortaApolipoprotein EAreaArterial Fatty StreakBiological AvailabilityBloodBronchial Provocation TestsC57BL/6 MouseCardiopulmonaryCardiovascular DiseasesCardiovascular systemCategoriesCessation of lifeChemicalsChronicCigaretteCigarette SmokerClinicalCollagenCotinineDataDepositionDevicesDrug KineticsEFRACElastic FiberElasticityElectronic cigaretteEvaluationExposure toFDA approvedFamily Smoking Prevention and Tobacco Control ActGenerationsHealthHealth Care CostsHeartHeterogeneityInhalationJUULKnowledgeLeft ventricular structureLungMagnetic Resonance ImagingMeasuresMechanicsModelingMusNebulizerNicotineNoseOutcomeOxygenPropertyProxyPulmonary Heart DiseaseRegulationRelaxationReportingResearchResistanceRespiratory SystemRiskRisk FactorsSafetySaltsShortening FractionSmokeSmokerSmokingSodium ChlorideSolventsSourceStructureSystemTestingTissuesTobaccoVirginiaWild Type MouseWorkloadYouthabdominal aortaabsorptionaerosolizedbasecardiovascular risk factorcigarette smokecombustible cigarettecomorbiditydesignelectronic cigarette useepidemiologic dataexperienceexperimental studyexposure to cigarette smokehypercholesterolemiainterestirritationmechanical propertiesmethacholinemouse modelnicotine cravingnicotine vaporpressurerespiratoryresponsesmoke inhalationsmoking cessationsmoking-related diseasetobacco flavortobacco productstranslational potentialvaping
项目摘要
PROJECT SUMMARY
New generation pod-style nicotine salt e-cigarettes (e-cigspod) are popular because of their sleek design and
ability to deliver nicotine levels similar to those of conventional tobacco cigarettes (cigs). Nicotine salts are easier
to inhale than the free-base form of nicotine found in previous generation e-cigs. While the long-term health
impact of cig smoke is well known, the consequences of chronic e-cig use remain in question, and data is needed
to justify immediate FDA regulations. A substantial portion of smokers are unsuccessful in using e-cigs to support
their cessation efforts and instead become dual users. The chemical profile of cig smoke and e-cigpod aerosols
is different, which suggests that the health effects of chronic smoking and vaping may not fully overlap. Building
upon this, we hypothesize that cig smoking and e-cigpod vaping, are independent risk factors for cardiopulmonary
disease, whose superposition exacerbates the maladaptive remodeling of the lungs, heart, and vasculature
compared to either practice alone. To test this hypothesis, we will expose hypercholesterolemic and wildtype
mice to nebulized nicotine, aerosolized solvent carrier, e-cigpod aerosols, and cig smoke (naïve mice), or a
combination of the two (both naïve and previously cig smoke-exposed mice) and we will compare the structural
and functional remodeling of the cardiovascular and respiratory systems. We will generate e-cigpod aerosols from
pods in Tobacco flavor at 5% nicotine strength. Motivated by the idea that smokers who use e-cigs as cessation
aids may vape until they satisfy their nicotine cravings, we will perform experiments to achieve equal cotinine
bioavailability in the mouse blood, while maintaining the same daily duration of exposure. We will measure the
mechanical properties of the of aorta (tissue stiffness, distensibility, and elastic storage), heart (fractional
shortening and ejection fractions), and lungs (resistance and elastance). We will characterize tissue
microstructure (air space sizes, collagen content, and elastic fiber integrity) to highlight the factors that most
contribute to the observed functional changes. Knowledge gained from this project will provide scientific evidence
in support of data-driven e-cig regulation under The Family Smoking Prevention and Tobacco Control Act
(FSPTCA), specifically concerning the health risks of dual combustible and electronic cigarette use.
项目总结
新一代豆荚式尼古丁盐电子烟(e-cigspod)因其时尚的设计和
能够提供与传统烟草香烟(CIG)相似的尼古丁水平。尼古丁盐更容易
比上一代电子烟中发现的游离碱形式的尼古丁更容易吸入。而长期的健康
香烟烟雾的影响是众所周知的,长期使用电子香烟的后果仍然存在疑问,需要数据
以证明FDA立即出台的法规是合理的。相当一部分吸烟者不成功地使用电子烟来支持
他们的戒烟努力,而不是成为双重用户。雪茄烟雾和电子烟荚气溶胶的化学分布
是不同的,这表明长期吸烟和蒸发对健康的影响可能并不完全重叠。建房
在此基础上,我们假设吸烟和吸电子烟是心肺疾病的独立危险因素。
疾病,其叠加加剧肺、心脏和血管系统的不适应重塑
而不是单独练习。为了验证这一假设,我们将揭示高胆固醇血症和野生型
小鼠对雾化尼古丁、雾化溶剂载体、电子烟雾剂和香烟烟雾(幼稚的小鼠),或
两者的组合(包括幼稚的和之前暴露于香烟烟雾的小鼠),我们将比较结构
心血管和呼吸系统的功能重塑。我们将从以下方面产生电子烟盒气雾剂
烟草香料中的豆荚,尼古丁强度为5%。动机是使用电子烟戒烟的吸烟者
艾滋病可能会蒸发,直到他们满足尼古丁的渴望,我们将进行实验,以实现等量可替宁
小鼠血液中的生物利用度,同时保持每天相同的暴露时间。我们将测量
主动脉(组织硬度、扩张性和弹性储存)、心脏的机械特性(分数
缩短和射血分数)和肺(阻力和弹性)。我们将描述组织的特征
微观结构(空气空间大小、胶原蛋白含量和弹性纤维完整性)突出了最重要的因素
有助于观察到的功能变化。从这个项目中获得的知识将提供科学证据
支持《家庭吸烟预防和烟草控制法案》下的数据驱动的电子烟监管
《烟草控制框架公约》(FSPTCA),具体涉及可燃香烟和电子香烟双重使用的健康风险。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chiara Bellini其他文献
Chiara Bellini的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chiara Bellini', 18)}}的其他基金
Cardiopulmonary Risk Assessment from Smoke Exposure at the Wildland Urban Interface
荒地城市界面烟雾暴露的心肺风险评估
- 批准号:
10563220 - 财政年份:2022
- 资助金额:
$ 75.51万 - 项目类别:
Evaluation of aortic stiffening as an early indicator of anthracycline-induced cardiotoxicity
主动脉硬化作为蒽环类药物引起的心脏毒性早期指标的评估
- 批准号:
9809540 - 财政年份:2019
- 资助金额:
$ 75.51万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 75.51万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 75.51万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 75.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 75.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 75.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














{{item.name}}会员




