Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

项目摘要 这是对NIGMS授权的NIGMS行政补充的请求R35GM119560，以购买J- 1100圆二色(CD)光谱偏振仪。我们之前的结构和功能研究使我们能够 设计针对整合素相关疾病的肽类抑制剂，如血栓性疾病、心血管疾病 疾病，以及许多自身免疫性疾病。我们的数据表明，模拟多肽的螺旋性是 它的抑制功能。使用J-1100 CD光谱偏振仪将提供必要的功能 最大限度地提高生产率，充分实现拟议研究项目的目标。机构配套资金 将有助于购买这一工具。

Project Summary This is a request for an NIGMS Administrative Supplement to NIGMS grant R35GM119560, to purchase a J- 1100 Circular Dichroism (CD) Spectropolarimeter. Our previous structural and functional studies allow us to design peptidomimetic inhibitors targeting integrin-related diseases such as thrombotic disorders, cardiovascular diseases, and many autoimmune diseases. Our data suggest the helicity of the peptidomimetics is required for its inhibitory function. Access to the J-1100 CD Spectropolarimeter will provide the necessary capabilities to maximize productivity and fully achieve the aims of the proposed research project. Institutional matching funds will contribute to the purchase of this instrument.