Community Developed Technology-Based Messaging to Increase SARS-CoV-2 Vaccine Uptake Among People Who Inject Drugs

项目摘要/摘要 注射毒品(PWID)的人感染SARS-CoV-2的风险不成比例， 导致新冠肺炎的病毒。不幸的是，由于耻辱、害怕受到虐待和其他因素，PWID是 与其他人群相比，接种疫苗的可能性要小得多。非洲裔美国人和拉美裔美国人也 与白人相比，新冠肺炎面临着不成比例的感染风险和更高的死亡率 由于长期存在的医疗不信任等问题，接种疫苗的可能性也要小得多。为非裔美国人 拉丁裔PWID、COVID相关风险进一步增加，接种疫苗的可能性变得更小。 作为回应，我们建议继续与纽约减少伤害教育工作者合作 (NYHRE)是纽约市一个著名的社区组织，服务于非裔美国人和拉丁裔PWID。 为了在目标人群中增加接种SARS-CoV-2疫苗，我们将首先收集社区咨询意见 董事会(CAB)，我们将在项目的所有阶段进行咨询，然后进行一系列定性访谈(n=20) 为了更好地了解PWID中检测和接种疫苗的障碍，以及我们如何潜在地解决这些障碍 通过基于技术的消息传递。然后，我们将与CAB和其他PWID参与者(n=30)合作，以 反复开发、评估和改进英语和西班牙语的干预视频和文本消息内容。 接下来，我们将通过受访者驱动抽样招募一个单独的PWID样本(n=500)来评估 这些新创建的干预材料是临床试验的一部分。注册后，将为参与者提供 免费接种SARS-CoV-2疫苗。为了增加我们审判的严谨性，我们只会提供我们的干预 提供给不接受疫苗接种的参与者的材料(根据目前的PWID疫苗接种率 对于流感，我们预计绝大多数人将下降)。那些最初没有接种疫苗的人将是 随机分为两个干预组之一：无视频组和视频文字组。无视频组 每周将收到旨在解决形成性研究中确定的疫苗接种障碍的短信。 视频文本组将收到相同的文本，以及指向我们与NYHRE工作人员和 客户解决接种SARS-CoV-2疫苗的障碍。我们的干预将跟踪这两组人的应答率。 主要结果衡量标准将是在登记后的最初几周内接种疫苗，以及随后的 干预期按治疗组划分。其他结果将包括按人口统计的疫苗接种率， 包括种族/民族和主要语言(即说英语的参与者对特定问题的反应是否不同 (与说单一西班牙语的人相比，干预措施的组成部分)。 如果被证明是成功的，这种方法可以在更多体验健康的人群中复制 在美国各地，不同的语言之间存在着差异。

Project Summary/Abstract People who inject drugs (PWID) experience disproportionate risk of being infected with SARS-CoV-2, the virus that causes COVID-19. Unfortunately, due to stigma, fear of mistreatment, and other factors, PWID are far less likely to be vaccinated compared to other populations. African American and Latino populations also face disproportionate risk of infection and far greater COVID-19 death rates compared to White populations, yet due to issues including longstanding medical mistrust are also far less likely to vaccinate. For African American and Latino PWID, COVID-related risks increase even further and vaccination becomes even more unlikely. In response, we propose to continue our collaboration with New York Harm Reduction Educators (NYHRE) a prominent New York City community based organization serving African American and Latino PWID. To increase SARS-CoV-2 vaccination among our target population, we will first assemble a community advisory board (CAB) that we will consult at all phases of the project, then conduct a series of qualitative interviews (n=20) to better understand barriers to testing and vaccination among PWID, and how we can potentially address these via technology-based messaging. We will then work with our CAB and additional PWID participants (n=30) to iteratively develop, evaluate, and refine intervention video and text message content in English and Spanish. Next, we will recruit a separate sample of PWID (n=500) via respondent driven sampling to evaluate these newly created intervention materials as part of a clinical trial. Upon enrollment, participants will be offered a free vaccination against SARS-CoV-2. To increase the rigor of our trial, we will only provide our intervention materials to participants who do not accept vaccination when offered (based on current rates of PWID vaccination against influenza we expect the overwhelming majority will decline). Those who do not initially vaccinate will be randomized into one of two intervention groups: a no video group, and a video text group. The no video group will receive weekly text messages designed to address barriers to vaccination identified in formative research. The video text group will receive the same texts, along with links to videos we develop with NYHRE staff and clients to address barriers to SARS-CoV-2 vaccination. Our intervention will track response rates in both groups. Primary outcome measures will be vaccination within the initial weeks following enrollment and the subsequent intervention period by treatment group. Additional outcomes will include vaccination rates by demographic, including race/ethnicity and primary language (i.e. do English speaking participants respond differently to specific intervention components compared to monolingual Spanish speakers). If shown successful this approach can be replicated with additional populations that experience health disparities, and in different languages across the United States.