Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program

项目摘要/摘要 这项提案是对为期5年的国家研究服务奖11-15年的续展申请 机构研究补助金，以支持艾滋病毒流行病学和预防科学的培训计划 约翰霍普金斯大学彭博公共卫生学院和约翰霍普金斯大学医学院 (SOM)，题为“约翰·霍普金斯大学艾滋病毒流行病学和预防科学培训计划”。这个 该项目将由Shruti Mehta博士领导，他是公共卫生硕士，过去一直担任该项目的副主任 十年了。我们正在请求支持3名博士后和4名博士后实习生，该计划的任务是培训 博士后学生和博士后研究员将成为最优先关注的艾滋病毒领域的领导者 在三个培训轨道上拥有高级能力和最新技能的研究：1)艾滋病毒流行病学 和实施科学方法，包括(1)人口和研究设计方面的培训，包括 确定、招募和留住与国内和国际艾滋病毒研究相关的人群以及 实施科学的当代设计；(2)感染和感染的人群中的测量问题 艾滋病毒风险，包括监测的创新方法、以人口为基础的疾病负担衡量和 MHealth/在线数据收集战略；(3)推理技术，包括因果推理、数学 建立模型；(4)综合研究结果并将其付诸实践，包括系统审查， 成本效益分析和艾滋病毒方案实施的障碍；2)艾滋病毒临床和实验室 科学包括以下方面的培训：(1)流行病学、预防和管理重大混合感染 艾滋病毒，包括丙型肝炎病毒感染、结核病和SARS-CoV-2/新冠肺炎； 艾滋病毒的发病机制和与年龄相关的共病；以及(3)测量和使用(例如，系统动力学) 遗传、病毒学和免疫学因素，这些因素可以帮助我们了解发病机制和 艾滋病毒的传播；和3)艾滋病毒预防科学，包括如何预防和减少流行率和 通过培训感染艾滋病毒(1)设计和分析艾滋病毒生物医学、行为和综合 预防试验战略，包括作为预防研究的治疗(TasP)、PrEP、艾滋病毒疫苗和 被动免疫治疗试验，以及(2)以社区为基础的人群一级艾滋病毒预防和治疗方法 控制力。我们的计划通过JHU艾滋病研究中心(CFAR)完全整合在一起 为艾滋病毒工作的受训者创造了一个丰富和互动的环境，特别是 由流行病学、临床、预防和合作开展的创新、富有成效和协作的艾滋病毒研究 约翰霍普金斯大学BSPH和SOM的实施科学家。

PROJECT SUMMARY / ABSTRACT This proposal is a renewal application for years 11-15 of a 5-year National Research Service Award Institutional Research Grant to support a training program in HIV Epidemiology and Prevention Sciences at the Johns Hopkins Bloomberg School of Public Health (BSPH) and the Johns Hopkins School of Medicine (SOM), entitled the “Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program.” The program will be led by Shruti Mehta PhD, MPH who has been the deputy director of this program for the past 10 years. We are requesting support for 3 pre- and 4 post-doctoral trainees The program mission is to train pre-doctoral students and post-doctoral fellows to become leaders at the forefront of highest priority HIV research with advanced competencies and state-of-the-art skills in three training tracks: 1) HIV Epidemiology and Implementation Science Methods including training in (1) Populations and Study Designs, including identifying, recruiting, and retaining populations relevant for domestic and international HIV research as well as contemporary designs for implementation science; (2) Measurement issues in populations infected with and at risk for HIV, including innovative methods for surveillance, population-based measures of disease burden and mHealth/online strategies for data collection; (3) Inference techniques, including causal inference, mathematical modeling; and (4) Synthesis and Implementation of research findings to practice, including systematic reviews, cost-effectiveness analyses, and barriers to implementation of HIV programs; 2) HIV Clinical and Laboratory Sciences including training in (1) the epidemiology, prevention and management of major co- infections with HIV including hepatitis C virus (HCV) infection, tuberculosis and SARS-CoV-2/COVID-19; (2) epidemiology and pathogenesis of HIV and age-associated co-morbidities; and (3) Measurement and use (e.g., phylodynamics) of genetic, virologic and immunologic factors that can inform our knowledge of the pathogenesis and transmission of HIV; and 3) HIV Prevention Sciences including how to prevent and reduce the prevalence and incidence of HIV through training in (1) Design and Analysis of HIV biomedical, behavioral and integrated strategies for prevention trials, including treatment as prevention research (TasP), PrEP, HIV vaccine and passive immune-therapy trials, and (2) Community-based population-level approaches to HIV prevention and control. Our program, which is fully integrated through the JHU Center for AIDS Research (CFAR) has resulted in a rich and interactive environment for trainees working in HIV augmented by the exceptionally innovative, productive and collaborative HIV research conducted by epidemiological, clinical, prevention and implementation scientists throughout Johns Hopkins BSPH, and SOM.