Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program

7.项目摘要 本提案是第二个5年期国家研究服务奖机构的延续申请 研究补助金，以支持在艾滋病毒流行病学和预防科学的培训计划在约翰 霍普金斯布隆伯格公共卫生学院（BSPH）和约翰霍普金斯医学院（SOM）， 名为“约翰霍普金斯艾滋病流行病学和预防科学培训计划”。的 该项目由主任Chris Beyrer（医学博士、公共卫生硕士）和副主任Shruti Mehta（博士、公共卫生硕士）领导。我们 请求为3名博士前和4名博士后受训人员提供支助，增加了2名博士后 上一个资助期的学员。该计划的使命是培养博士前学生和博士后 研究员成为领导人在最优先的艾滋病毒研究的前沿与先进的能力， 在三个培训轨道的最先进的技能：艾滋病毒流行病学和实施科学方法 包括（1）人群和研究设计，包括识别、招募和保留;（2） 艾滋病毒感染者的计量问题，包括监测、招募、估计和 （3）推断技术，包括因果关系的现代分析方法， 推理和数学建模;（4）研究成果的合成和公开实施 卫生实践;艾滋病毒临床和实验室科学，包括（1）流行病学、预防 和治疗HIV的主要合并感染，包括丙型肝炎病毒（HCV）感染和结核病;（2） 艾滋病毒的流行病学和发病机制以及与年龄相关的合并症;以及（3）测量和使用 遗传、病毒学和免疫学因素，可以为我们了解发病机制和传播提供信息 艾滋病毒预防科学，包括如何预防和减少艾滋病毒的流行和发病率 通过以下方面的培训：（1）艾滋病毒生物医学、行为和综合预防试验的设计和分析， 包括作为预防研究的治疗（TasP），口服和局部PrEP试验，艾滋病毒疫苗试验和被动 免疫治疗试验，以及（2）以社区为基础的人群一级艾滋病毒预防和控制方法 超越个人行为的改变。我们的计划，这是完全通过JHU艾滋病中心整合 研究（CFAR）为从事艾滋病毒工作的学员提供了丰富且互动的环境，并通过以下方式得到增强 由流行病学、临床、 约翰霍普金斯BSPH和SOM的预防和实施科学家。

7. PROJECT SUMMARY This proposal is a renewal application for a second 5-year National Research Service Award Institutional Research Grant to support a training program in HIV Epidemiology and Prevention Sciences at the Johns Hopkins Bloomberg School of Public Health (BSPH) and the Johns Hopkins School of Medicine (SOM), entitled the “Johns Hopkins HIV Epidemiology and Prevention Sciences Training Program.” The program is led by Director Chris Beyrer MD, MPH, and Deputy Director Shruti Mehta PhD, MPH. We are requesting support for 3 pre- and 4 post-doctoral trainees, which represents an increase of 2 post-doctoral trainees from our prior funding period. The program mission is to train pre-doctoral students and post-doctoral fellows to become leaders at the forefront of highest priority HIV research with advanced competencies and state-of-the-art skills in three training tracks: HIV Epidemiology and Implementation Science Methods including training in (1) Populations and Study Designs, including identification, recruitment and retention; (2) Measurement issues in HIV populations, including innovative methods for surveillance, recruitment, estimation of HIV prevalence and incidence, (3) Inference techniques, including modern analytical methods for causal inference and mathematical modeling; and (4) Synthesis and Implementation of research findings to public health practice; HIV Clinical and Laboratory Sciences including training in (1) the epidemiology, prevention and treatment of major co- infections with HIV including hepatitis C virus (HCV) infection and tuberculosis; (2) epidemiology and pathogenesis of HIV and age-associated co-morbidities; and (3) Measurement and use of genetic, virologic and immunologic factors that can inform our knowledge of the pathogenesis and transmission of HIV; HIV Prevention Sciences including how to prevent and reduce the prevalence and incidence of HIV through training in (1) Design and Analysis of HIV biomedical, behavioral and combination prevention trials, including treatment as prevention research (TasP), oral and topical PrEP trials, HIV vaccine trials and passive immune-therapy trials, and (2) Community-based population-level approaches to HIV prevention and control beyond individual behavior change. Our program, which is fully integrated through the JHU Center for AIDS Research (CFAR) has resulted in a rich and interactive environment for trainees working in HIV augmented by the exceptionally innovative, productive and collaborative HIV research conducted by epidemiological, clinical, prevention and implementation scientists throughout Johns Hopkins BSPH, and SOM.