Minnesota Muscle Training Program

一组调查人员试图重新支持明尼苏达州肌肉训练计划(MMTP)，NIH 明尼苏达大学肌肉研究T32跨学科培训计划，面向两名博士前 以及博士后科学家。该项目始于2001年，主要侧重于基础肌肉研究。自.以来 当时，UMN高度重视在所有层面上扩大肌肉研究，特别是 转化性研究，旨在开发新的治疗方法。该机构已经招聘了 在肌肉疾病和治疗方面的国际知名研究人员，并建立了新的设施， 支持这项研究。在上一个资助期，进一步的发展使我们提高了 已经很出色的培训计划(2011年和2016年满分为10分) 根据教员的资助和培训记录，以及按合格受训人员的数量，他们的出版记录 在培训期间，以及培训后他们的研究生涯取得成功。该项目的教职员工来自几个 各系，但他们的研究生注册跨部门研究生课程。 生物化学、分子生物学和生物物理学(BMBB)或分子、细胞、发育生物学和 遗传学(MCDBG)，它共享一个共同的招生计划(分子细胞和结构生物学， MCSB)和一年级课程。培训计划的智力中心是为期一学期的强化培训 名为“肌肉”的课程，由MMTP主任指导，由MMTP教员授课，该课程强调 包括基础研究和翻译研究。本课程已扩展，以适应不断增加的 强调肌肉疾病和治疗。每周一次的肌肉杂志俱乐部(每两周一次)加强了这一点 内部研讨会计划，每月一次的外部研讨会，包括肌肉研究的国际领导者，以及 一年一度的MMTP研讨会，培训学院所有研究小组的成员积极出席并 讨论他们的研究，主题演讲者是一位国际知名的肌肉研究人员。一个 MMTP的显著优势在于其领导力。2001年创立该项目的主任(托马斯)是一名 肌肉分子生物物理学的世界领先者，自1980年以来一直获得NIH对肌肉的资助(包括两个 优秀奖)，并指导了100多名博士后和博士后实习生，其中大多数人 继续在肌肉研究领域从事富有成效的独立职业。这一计划现在将通过MPI得到加强 结构，托马斯由埃尔瓦蒂和洛威加入。埃瓦斯蒂是肌肉生化领域的世界领先者。 他是肌营养不良症中心的研究主任，该中心与MMTP密切相关。 Lowe是衰老、疾病和性别差异领域的肌肉生理学方面的世界专家。这所大学 为MMTP提供强有力的机构支持，包括慷慨提供配套资金。初级阶段 MMTP的目标是帮助这些杰出的博士后和博士后实习生发展智力和 作为肌肉研究领域的独立研究人员和教育工作者，从事富有成效的职业所需的技术工具。

A group of investigators seeks to renew support for the Minnesota Muscle Training Program (MMTP), the NIH T32 interdisciplinary training program in muscle research at the University of Minnesota, for both predoctoral and postdoctoral scientists. This program began in 2001 with a primary focus on basic muscle research. Since that time, UMN has placed a high priority on the expansion of muscle research at all levels, particularly translational research, aimed at the development of new therapeutic approaches. The institution has recruited internationally prominent researchers in muscle disease and therapy and has established new facilities that support this research. In the previous funding period, further developments have led us to improve the quality of an already outstanding training program (which received a perfect score of 10 in 2011 and 2016), as measured by the funding and training records of the faculty; and by the number of qualified trainees, their publication record during training, and their research career success after training. Program faculty are drawn from several departments, but their graduate students are enrolled in the interdepartmental graduate programs in Biochemistry, Molecular Biology, and Biophysics (BMBB) or Molecular, Cellular, Developmental Biology and Genetics (MCDBG), which share a common admissions program (Molecular Cellular and Structural Biology, MCSB) and first-year curriculum. The intellectual center of the training program is an intensive one-semester course entitled “Muscle,” directed by the MMTP Director and taught by the MMTP faculty, which emphasizes both basic and translational research. This course has been expanded to accommodate an increasing emphasis on muscle disease and therapy. This is augmented by a weekly Muscle Journal Club, a biweekly internal seminar program, a monthly external seminar including international leaders in muscle research, and an annual MMTP Symposium in which all members of the training faculty’s research groups actively present and discuss their research, featuring a keynote speaker who is an internationally prominent muscle researcher. A significant strength of MMTP is its leadership. The Director (Thomas), who founded the program in 2001, is a world leader in the molecular biophysics of muscle, has had NIH funding on muscle since 1980 (including two MERIT Awards), and has mentored more than 100 predoctoral and postdoctoral trainees, most of whom have gone on to productive independent careers in muscle research. This program will now be strengthened by MPI structure, with Thomas joined by Ervasti and Lowe. Ervasti is a world leader in the biochemistry of muscle disease, and is Research Director for the Muscular Dystrophy Center, which is closely associated with MMTP. Lowe is a world expert on muscle physiology in areas of aging, disease, and gender differences. The University provides strong institutional support for MMTP, including a generous offer of matching funds. The primary goal of MMTP is to help these exceptional predoctoral and postdoctoral trainees to develop the intellectual and technical tools needed for productive careers as independent investigators and educators in muscle research.