How age & sex impact the transcriptional control of mammalian muscle growth

在生命的各个阶段，保持健康的肌肉都是至关重要的。衰老与肌肉的丧失有关，由于与年龄相关的基因表达和反应性的变化，年龄较大的肌肉对生长具有抵抗力。许多基因在男性和女性肌肉中的表达不同，这可能与肌肉生长和衰老的性别差异有关。这个项目将产生新的知识，关于哪些基因和生物途径在决定哺乳动物肌肉的大小和跨寿命和性别之间的增长方面至关重要。这一知识的应用可能会导致未来的方法，使澳大利亚人能够健康地开始生活，促进健康老龄化，并对农业和作为食物来源的肌肉产生影响。

Maintaining healthy muscle is crucial throughout all stages of life. Aging is associated with the loss of muscle and older muscles are resistant to growth due to age-related changes in gene expression and responsiveness. Many genes are expressed differently in male versus female muscle, which may have implications for sex-differences in muscle growth and aging. This project will generate new knowledge on which genes and biological pathways are crucial in determining mammalian muscle size and growth across the lifespan and between the sexes. Application of this knowledge may lead to future approaches to enable a healthy start to life and promote healthy aging in Australians and have implications for agriculture and muscle as a food source.