Y-SPAN: Yale Translational Cerebroprotection Program in SPAN

项目摘要。 该项目建议在耶鲁大学为NINDS计划建立一个啮齿动物临床前中风疗法试验场 卒中临床前评估网络(SPAN)支持急性脑保护的转译研究。 包括基础科学家在内的研究小组研究中风后损伤的机制，翻译 研究人员、生物医学成像专家和临床试验人员形成了高度协作和互动的 NINDS在一个国家的监督下，致力于测试NINDS选择的候选脑保护剂 协调中心。总的目标是确定最有希望的新中风疗法的候选者 然后在临床试验中进行测试，推进对中风患者的护理。 在项目的目标1中，我们将建立SPAN标准操作协议和时间表，用于测试 干预措施。在目标2中，我们将测试候选脑保护剂在多种啮齿动物模型中的效果。 短暂性大脑中动脉闭塞，包括包括衰老和并存的模型。在一个 探索性目标3，我们将测试创新的方法，以提高广度测试的预测价值 确定对患者有效并增强SPAN影响的候选治疗方案。

Project Summary. The project proposes a rodent preclinical stroke therapeutics testing site at Yale for the NINDS program Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection. A team of investigators including basic scientists studying mechanisms of injury after stroke, translational researchers, biomedical imaging specialists, and clinical trialists form a highly collaborative and interactive team dedicated to testing candidate cerebroprotectants selected by NINDS under the oversight of a national coordinating center. The overall goal is to identify the most promising candidates for novel stroke therapies to then be tested in clinical trials, advancing the care for stroke patients. In Aim 1 of the project we will establish the SPAN standard operating protocols and timeline for testing of the interventions. In Aim 2, we will test the efficacy of candidate cerebroprotectants in multiple rodent models of transient middle cerebral artery occlusion, including models incorporating aging and comorbidities. In an exploratory Aim 3, we will test innovative methods to improve the predictive value of the SPAN testing protocols to identify candidate treatments that will be efficacious in patients and enhance the impact of SPAN.