2023 Salivary Glands and Exocrine Biology GRC and GRS

项目总结 该提案要求部分支持第十三届戈登研究会议(GRC)和第三届 戈登研究研讨会(GRS)，题为唾液腺和外分泌生物学：理解 外分泌组织的分泌功能和疾病将于2023年1月29日至2月3日在 加州文图拉的福克斯喜来登酒店。GRC将包括关于外分泌腺的全体会议 唾液蛋白的发育，再生途径，功能相关性，膜功能 外分泌腺，了解自身免疫性疾病的病因，靶向炎症以延缓疾病 外分泌腺的发病机制和当前研究主题：病原体，如SARS-CoV2的相互作用。特邀演讲者 因为GRC将包括来自学术界、工业界和政府的知名科学家，会谈将包括两者 来自不同领域的资深和初级科学家将介绍当前未发表的关于主题的研究成果 被以前的会议组织者和与会者确定为该领域最感兴趣的。几个主题演讲 演讲者将被邀请发表关于干细胞疗法、临床基因组学和临床试验的研讨会。 Sjögren病，一种常见的自身免疫性疾病，影响外分泌腺并对 没有合适和有效的治疗方法的患者的生活质量。其中一个值得注意的特点是 GRC将是在GRC之前举行的GRS的延续，GRC于2017年首次推出，仅邀请 演讲者是世界各地不同实验室的研究生和博士后助理。 GRS的这些初级科学家也将参加GRC，他们中的许多人将被选为研讨会 这将包括在全体会议上。此外，GRC将每天举行海报会议，以实现 所有与会者在一个开放论坛中展示和讨论他们的数据。GRC和GRS的总体目标将是 促进科学交流，并在被视为具有 对制定改善人类健康的新战略产生重大影响。具体目标与 NIDCR的任务包括：1)向学术界、工业界和 并将初级和高级调查人员聚集在一个愉快的环境中，在那里他们将有 有机会在知识渊博的观众面前讨论未发表的发现，并参与广泛的 批判性研究讨论；2)提供研究生和博士后助理参加的GRS 谁将在他们的同龄人面前展示他们的新研究成果；3)强调 介绍外分泌生物学领域感兴趣的最新方法学，以实现 开发通过预防分泌障碍来改善人类健康的创新方法 器官。

PROJECT SUMMARY This proposal requests partial support for the thirteenth Gordon Research Conference (GRC) and the third Gordon Research Seminar (GRS) entitled Salivary Glands and Exocrine Biology: Understanding the Biology of Secretory Function and Diseases of Exocrine Tissues to be held from Back January 29th-February 3rd, 2023, at the Four Points Sheraton hotel in Ventura, CA. The GRC will include plenary sessions on exocrine gland development, regenerative approaches, functional relevance of salivary proteins, membrane functions in exocrine glands, understanding the etiology of autoimmune disease, targeting inflammation to retard disease pathogenesis and current topics in exocrine gland:pathogen such as SARS-CoV2 interactions. Invited speakers for the GRC will include eminent scientists from academia, industry and government and talks will include both senior and junior scientists from diverse fields who will present current unpublished research findings on subjects identified by previous meeting organizers and attendees as of greatest interest to the field. Several keynote speakers will be invited to deliver seminars on stem cell therapeutics, clinical genomics and clinical trials for Sjögren's disease, a common autoimmune disease that affects exocrine glands and negatively impacts the quality of life of patients for whom no suitable and effective therapies are available. A noteworthy feature of this GRC will be continuation of a GRS to be held just prior to the GRC, first offered in 2017, that will invite only speakers who are graduate students and postdoctoral associates in a wide variety of laboratories worldwide. These junior scientists at the GRS will also attend the GRC where many of them will be chosen to give seminars that will be included in the plenary sessions. In addition, poster sessions will be held daily at the GRC to enable all attendees to present and discuss their data in an open forum. The overall goal of the GRC and GRS will be to foster scientific exchanges and engender research collaborations in disciplines that are viewed as having a major impact on the development of novel strategies to improve human health. Specific Aims in line with the NIDCR mission include: 1) to present a program of topical interest to scientists in academia, industry and government and to assemble junior and senior investigators in a pleasant setting where they will have opportunities to discuss unpublished findings before a knowledgeable audience and engage in a wide range of critical research discussions; 2) to offer a GRS to be attended by graduate students and postdoctoral associates who will present their novel research findings before an audience of their peers and; 3) to emphasize presentations on state-of-the-art methodologies of interest to the exocrine biology field towards the goal of developing innovative approaches to the improvement of human health by preventing disorders of secretory organs.