Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) of the Cooperative Human Tissue Network (CHTN)

项目总结/摘要 本提案将阿巴拉契亚和五大湖研究的资源和经验组织起来 生物标本资源（AGL-RBR）作为NCI合作人体组织的成人部门参与 Network（CHTN）.我们的AGL-RBR病理学家团队能够有效地为残余患者提供 用于基础和早期转化癌症研究以及生物标志物研究的同意生物标本 支持个性化医疗的研究。俄亥俄州州立大学（OSU）医院和詹姆斯癌症 俄亥俄州哥伦布的医院将作为协调/采购中心，而大学医院将作为协调/采购中心。 克利夫兰医学中心，俄亥俄州克利夫兰，布法罗大学附属医院，纽约州布法罗和大学 匹兹堡医疗中心沙迪赛德，匹兹堡，宾夕法尼亚州和相关医院将发挥作用， 地理分布的采购/生物储存地点。OSU协调中心-研究员 管理服务将管理研究者申请和批准以及研究者生物标本 请求联网。俄勒冈州立大学生物标本管理服务将处理组织质量控制， 生物标本的储存和运输以及CHTN费用的计费、收集和月度核算。组织 采购支持定制生物标本采集，包括研究者提供的新型保存液 或方法。可用的信息学支持收集与供体同意、生物标本， 调查员和账单运输的生物样本包括每个样本的编辑病理学和QC报告 运送生物样本。OSU新鲜采集组织的病理学报告包括临床上适当的 分子测试如果IRB批准，研究者还可以要求从 OSU信息仓库（IW）和其他实验室检测，如免疫组织化学，组织 微阵列构建、数字显微术或数字形态测量学。生物标本捐献者隐私和 保密性是AGL-RBR生物标本管理提案的基本要素， 生物样本是患者同意并编码的。脱链可用于特殊组织， 在采购时同意。OSU采购计划加入了OSU综合癌症中心 （OSUCCC）在2016年部署全面癌症护理®（TCC）协议， 同意.捐赠者同意将其过去、现在和未来的所有遗骸充分用于未来的研究 IRB批准的研究人员。采购/生物储存地点在以下方面也有类似的同意程序： 地方科学或技术知识或发现获得的行为我们的组织 采购/保存计划将在国家和国际科学和技术 会议，以促进生物标本科学的发展，招募新的研究人员谁有研究 人类生物标本研究最符合人类的利益，并向研究界和公众提供信息。

PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Appalachian and Great Lakes Research Biospecimen Resource (AGL-RBR) for participation as an Adult Division of the NCI Cooperative Human Tissue Network (CHTN). Our AGL-RBR group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, University at Buffalo hospital affiliations, Buffalo, NY and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Coordinating Center- Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections and monthly accounting. Tissue Procurement supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology Reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may also request, if IRB approved, extensive clinical data available from the OSU Information Warehouse (IW) and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the AGL-RBR biospecimen management proposal so that all procured biospecimens are patient consented and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the Total Cancer Care® (TCC) protocol in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research all of their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository sites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.