Novel Nanotechnology for the Delivery of Amyloid and Tau aggregation Targeting siRNA for a potential Alzheimer’s Disease Therapy
Novel Nanotechnology for the Delivery of Amyloid and Tau aggregation Targeting siRNA for a potential Alzheimer’s Disease Therapy
批准号:
nhmrc : GNT1166024
负责人:
金额:
$47.26万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 --
中文摘要
治疗神经退行性疾病的一个关键挑战是跨越血脑屏障(BBB)的药物输送。该项目将基于Glut转运体家族的作用开发先进的BBB“纳米航天器”,以促进BBB的传递和特定的神经元摄取,将纳米疗法运送到大脑中,并将关键蛋白质靶向未来的AD临床治疗。
英文摘要
A key challenge for treating neurodegenerative diseases is delivery of drugs across the blood–brain barrier (BBB). This project will develop advanced BBB “nanoshuttles” based on the role of the GLUT family of transporters to facilitate BBB delivery and specific neuronal uptake to transport nanotherapeutics into brain and target the key protein towards future AD clinical therapy.
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