Research Infrastructure Core

摘要 德克萨斯南方大学(TSU)是美国第二大HBCU，一直得到 RCMI计划已有多年，并显著加强了我们的研究环境。在上一次RCMI中 在资金周期内，我们成功地开发和部署了三个核心设施，包括药理学、分子 生物学和环境毒性。这些进展导致了富有成效的项目合作，包括 新的药物靶点，新的先导化合物，临床前的先导优化，和配方。然而，有一个 未得到满足的需求，以加强我们的研究资源和服务，包括研究设计，方法开发， 数据管理、专门的实验室技术(例如基因组编辑、动物工作技能)、仪器 利用率和协作网络。在此续签申请中，我们建议建立一个研究 生物医学和少数民族健康研究中心的基础设施核心(RIC)以支持 通过提供这些增强的服务进行研究和试点项目(除研究基础设施外 可通过以前的RCMI资金)提供给台湾省理工学院和外部用户，并促进 生物医学研究。具体目标是：支持CBMHR研究和试点项目并提供服务 为用户提高生物医学研究的质量和生产率(目标1)；开发和验证实验室 支持CBMHR研究和试点项目并向内部和外部用户提供培训的技术 (目标2)；以及促进联网，以增加合作研究项目和赠款申请(目标3)。 我们建议在六年内组建一支教师专家团队、顾问团队，并招募熟练的员工来支持我们的用户 我们在哪些领域拥有很强的专业知识和信誉。涉及的人员，包括核心董事，共同- 主任、教员专家团队成员和顾问将是重点研究领域的专家。我们也 建议促进与其他机构的专家进行新的合作，以整合各种研究资源 休斯顿地区。此外，我们将把包括费用结构在内的核心信息整合到CBMHR中 网站来推广我们的服务。建议的RIC的创新包括新颖的研究方法 开发、合作研究项目和赠款申请，以及协同增效。我们预计 建议的RIC将显著提高台州大学在生物医学和少数族裔健康方面的研究能力 研究，以便更具竞争力的拨款建议可以提交给不同的机构(例如，NIH)和更多 教师，特别是初级教师，将在他们的学术生涯中取得成功。

Abstract Texas Southern University (TSU), the nation’s second largest HBCU, has been continuously supported by the RCMI program for many years, and has significantly strengthened our research environment. In the last RCMI funding cycle, we successfully developed and deployed three core facilities including Pharmacology, Molecular Biology, and Environmental Toxicity. These advances have led to productive collaborations on projects including new drug targets, new lead compounds, preclinical lead optimization, and formulation. However, there is an unmet need to enhance our research resources and services to include study design, methodology development, data management, specialized laboratory techniques (e.g., genome editing, animal work skills), instrument utilization, and collaboration networks. In this renewal application, we propose to establish a Research Infrastructure Core (RIC) in the Center for Biomedical and Minority Health Research (CBMHR) to support research and pilot projects by providing these enhanced services (in addition to research infrastructure made available through previous RCMI funding) to TSU and external users and to facilitate new collaborations in biomedical research. The specific aims are: Support CBMHR research and pilot projects and provide services to users to enhance quality and productivity of biomedical research (Aim 1); Develop and validate laboratory techniques to support CBMHR research and pilot projects and provide trainings to internal and external users (Aim 2); and Facilitate networking to increase collaborative research projects and grant applications (Aim 3). We propose to form a faculty expert team, consultant team, and recruit skilled staff to support our users in six areas in which we have great expertise and credibility. The involved personnel, including core director, co- director, faculty expert team members, and consultants, will be experts in the key research areas. We also propose to facilitate new collaborations with experts in other institutions to integrate research resources across the Houston area. Additionally, we will integrate core information including fee structures into the CBMHR website to promote our services. Innovations of this proposed RIC include novel research methodology development, collaborative research projects and grant applications, and collaborative synergism. We expect that this proposed RIC will significantly enhance TSU’s research capability in biomedical and minority health research so that more competitive grant proposals can be submitted to different agencies (e.g., NIH) and more faculty, especially junior faculty, will be successful in their academic career.