Administrative Core

基因工程猪器官移植到狒狒体内： 免疫学和功能研究 核心D：行政核心（核心负责人：大卫K.C.库珀） 核心摘要/摘要 这一资金申请包括3个与基因工程猪肾有关的项目， 狒狒的肝脏和心脏移植。这3个项目将得到4个核心的支持， (A)提供先进的GE猪，（B）进行所有的免疫学测定，（C）进行所有的 组织病理学检查，以及（D）提供行政支持。 行政核心D的主要目标是提供一个组织结构， 促进拟议项目的成功，协调科学方法， 项目1-3与核心A、B和C之间的物流。项目之间的互动 和核心对于整个提案的成功至关重要。协作和 本提案参与者之间的协调将在会议期间获得最高优先权。 5-年的资金。

GENETICALLY-ENGINEERED PIG ORGAN TRANSPLANTATION IN BABOONS: IMMUNOLOGICAL AND FUNCTIONAL STUDIES CORE D: ADMINISTRATIVE CORE (Core Lead: David K.C. Cooper) CORE SUMMARY/ABSTRACT This request for funding includes 3 Projects relating to genetically-engineered pig kidney, liver, and heart transplantation in baboons. The 3 Projects will be supported by 4 Cores that will (A) provide the advanced GE pigs, (B) perform all of the immunological assays, (C) carry out all of the histopathology examinations, and (D) provide administrative support. The principal goal of Administrative Core D is to provide an organizational structure to facilitate the success of the proposed Projects, and to coordinate scientific approaches and logistics between Projects 1-3 and Cores A, B, and C. The interactions between the Projects and Cores are essential to the success of the proposal as a whole. Collaboration and coordination between the participants in this proposal will receive the highest priority during the 5-year period of funding.